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Methoxy PEG Butanoic Acid (mPEG-BA) is a stable, high-quality, carboxyl-functionalized polyethylene glycol (PEG) derivative, notably supplied by JenKem Technology and Sinopeg. It features a degradable linker connecting the mPEG chain to the carboxylic acid group, making it ideal for PEGylation, improving drug solubility, and extending circulation time in pharmaceuticals.
Key Aspects of Methoxy-PEG-BA (mPEG-BA):
- Structure: Consists of a methoxy-capped PEG chain and a butanoic acid group.
- Reactivity: The carboxyl (-COOH) group is used for conjugation with amine or hydroxyl-containing molecules via standard coupling techniques like EDC/NHS.
- Applications:
- PEGylation: Covalent modification of proteins, peptides, and nanoparticles to enhance stability.
- Drug Delivery: Formulation of controlled-release drug delivery systems.
- Surface Modification: Coating surfaces to reduce biofouling and improve biocompatibility.
- Key Suppliers: JenKem Technology and Sinopeg offer this product at various molecular weights, such as 10KDa, 20KDa, and 40KDa, typically stored at -20°C.
Other Methoxy PEG Derivatives:
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Web results
Methoxy PEG Butanoic Acid
JenKem Technology USA
https://jenkemusa.com › ... › Methoxy PEG Carboxyl
JenKem Technology USA
https://jenkemusa.com › ... › Methoxy PEG Carboxyl
JenKem Technology provides Methoxy PEG Butanoic Acid with superior quality attributes (Methoxy PEG Butyric Acid, mPEG-BA), a stable PEG carboxyl derivative.Read more
$130.00In stock
MPEG-BA Manufacturer
SINOPEG
https://www.sinopeg.com › mpeg-ba_p37
SINOPEG
https://www.sinopeg.com › mpeg-ba_p37
Methoxypoly(ethylene glycol) butanoic acid (mPEG-BA)is formed by a degradable linker connecting PEG polymer chain and thecarboxyl group, which is reactive with ...
Role of the Methoxy Group in Immune Responses to mPEG ...
PubMed Central (PMC) (.gov)
https://pmc.ncbi.nlm.nih.gov › articles › PMC3309606
PubMed Central (PMC) (.gov)
https://pmc.ncbi.nlm.nih.gov › articles › PMC3309606
by MR Sherman2012Cited by 206 — The goal of this research was to assess the role of the methoxy group in the immune responses to mPEG conjugates and the potential advantages of replacing mPEG ...Read more
Methoxy PEGs for PEGylation - JenKem Technology
JenKem Technology USA
https://jenkemusa.com › methoxy-pegs-for-pegylation
JenKem Technology USA
https://jenkemusa.com › methoxy-pegs-for-pegylation
Mar 25, 2026 — JenKem Technology provides high quality activated methoxy PEGs for PEGylation, with high purity, low polydispersity, and low to no diol content.Read more
What is METHOXY PEG-22/ DODECYL GLYCOL ...
Environmental Working Group
https://www.ewg.org › skindeep › ingredients › 703878-...
Environmental Working Group
https://www.ewg.org › skindeep › ingredients › 703878-...
Products with this ingredient are allowed for use in EWG VERIFIED but must meet use restrictions and warnings based on EWG review of company data.Read more
Methoxy PEG amine, Mp 750
Polysciences
https://polysciences.com › products › methoxy-peg-amin...
Polysciences
https://polysciences.com › products › methoxy-peg-amin...
The methoxy (-OCH₃) end provides hydrophilicity and minimizes non-specific interactions, making it ideal for bioconjugation and surface modifications.Read more
$263.946-day delivery
Accelerated clearance by antibodies against methoxy PEG ...
ScienceDirect.com
https://www.sciencedirect.com › science › article › pii
ScienceDirect.com
https://www.sciencedirect.com › science › article › pii
by YC Lin2023Cited by 30 — Anti-PEG antibodies that bind to the PEG “backbone” can accelerate drug clearance and detrimentally affect drug activity and safety.Read more
Methoxypolyethylene glycol 350 average mol wt 350 9004- ...
Sigma-Aldrich
https://www.sigmaaldrich.com › product › sigma
Sigma-Aldrich
https://www.sigmaaldrich.com › product › sigma
Methoxypolyethylene glycol 350 has been used in a study to assess the synthesis of a new class of thermosensitive micellar cyclotriphosphazenes.Read more
$122.00In stock$37.34 delivery
METHOXY PEG-100
U.S. Food and Drug Administration (.gov)
https://precision.fda.gov › ginas › app › substances
U.S. Food and Drug Administration (.gov)
https://precision.fda.gov › ginas › app › substances
METHOXY PEG-100 · CARBOWAX MPEG 5000 · MPEG-100 ; Official Name · Brand Name · Common Name ; English · English · EnglishRead more
Methoxy Peg Ba
SINOPEG
https://www.sinopeg.com › methoxy-peg-ba_sp
SINOPEG
https://www.sinopeg.com › methoxy-peg-ba_sp
Methoxypoly(ethylene glycol)butanoic acid. Molecular Weight: 10KDa, 20KDa, 40KDa. Package Size: 1g/bottle, 10g/bottle, 100g/bottle. Storage:Store at -20±5℃, ...
People also ask
What is methoxy PEG?
Methoxy PEG amine (mPEG-NH₂) is a monofunctional polyethylene glycol (PEG) derivative with a terminal amine (-NH₂) group, allowing for covalent conjugation to biomolecules, surfaces, or other reactive groups.
Methoxy PEG amine, Mp 5000 - Polysciences
Polysciences
https://polysciences.com › products › methoxy-peg-amin...
Polysciences
https://polysciences.com › products › methoxy-peg-amin...
What is PEG in Dr Pepper?
Poly (ethylene glycol) is also commonly used as a polar stationary phase for gas chromatography, as well as a heat transfer fluid in electronic testers. PEG is included in many or all formulations of the soft drink Dr Pepper, purportedly as an anti-foaming agent.
Polyethylene glycol - chemeurope.com
chemeurope.com
https://www.chemeurope.com › encyclopedia › Polyethy...
chemeurope.com
https://www.chemeurope.com › encyclopedia › Polyethy...
Why is PEG used in drug delivery?
Polyethylene glycol (PEG) is widely utilized in drug delivery and nanotechnology due to its reported “stealth” properties and biocompatibility. It is generally thought that PEGylation allows particulate delivery systems and biomaterials to evade the immune system and thereby prolong circulation lifetimes.
Questioning the Use of PEGylation for Drug Delivery - PMC
PMC - NIH
https://pmc.ncbi.nlm.nih.gov › articles › PMC4051498
PMC - NIH
https://pmc.ncbi.nlm.nih.gov › articles › PMC4051498