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    AI Overview
    N3-PEG4-CH2CO2-NHS (CAS 1807534-82-2) is a heterobifunctional crosslinker featuring an azide group (
    N3cap N sub 3
    𝑁3
    ) and an NHS ester connected by a 4-unit polyethylene glycol (PEG) chain. Used in ADC development and biomedical research, the NHS ester reacts with primary amines, while the azide participates in click chemistry (copper-catalyzed or strain-promoted) to label proteins and molecules. 
    Key Properties 
    • CAS Number: 1807534-82-2
    • Molecular Weight: 374.35 g/mol
    • Formula:
      𝐶14
      𝐻22
      𝑁4𝑂8
    • Structure: Azido-PEG4-CH2CO2-NHS (also known as N3-PEG4-SCM)
    • Synonyms: Azido-PEG4-acetic acid, 2,5-dioxo-1-pyrrolidinyl ester
    • Reactivity: Amine-reactive (NHS) and Click Chemistry-reactive (Azide) 
    Applications & Features 
    • Targeted Therapy: Used as a non-cleavable linker in antibody-drug conjugates (ADCs) to join antibodies with drugs.
    • Bioconjugation: Suitable for modifying proteins, peptides, and surface coatings due to the hydrophilic PEG linker.
    • Click Chemistry: The azide group reacts with alkynes, BCN, or DBCO to form stable triazole linkages.
    • Stability: N3-PEG4-CH2CO2-NHS is typically less stable in aqueous environments than NHS ester compounds linked with a propionic acid bridge (e.g., N3-PEG4-SPA). 
    Commonly Supplied By: 
    • Biopharma PEG
    • SINOPEG
    • BroadPharm
    • TargetMol Chemicals 
    • N3-PEG4-SPA | CAS:944251-24-5 - Biopharma PEG
      N3-PEG4-SPA (Azido-PEG4-NHS Ester) is a heterobifunctional PEG linker containing an azide group and an NHS ester. The azide group ...
      Biopharma PEG
    • Azido-PEG-NHS ester, MW 2,000 - BroadPharm
      Azido-PEG-NHS ester, MW 2,000 (N3-PEG-SPA, MW 2,000) is a Click chemistry-reactive PEG active ester containing an azide group. Azi...
      BroadPharm
    • N3-PEG4-C2-NHS ester | ADC Linker | 944251-24-5 | AdooQ®
      N3-PEG4-C2-NHS ester is a non-cleavable 4-unit polyethylene glycol (PEG) linker designed for use in the synthesis of antibody-drug...
      Adooq Bioscience
    • N3-PEG4-CH2CO2-NHS | CAS:1807534-82-2 | Huateng Pharma ...
      CAS No.： 1807534-82-2 · Synonyms： Azido-PEG4-CH2CO2-NHS N3-PEG4-SCM · Purity： ≥95% · Molecular formula： C14H22N4O · Molecular weig...
      en.huatengsci.com
    • Azido-PEG4-CH2CO2-NHS - Safety Data Sheet - ChemicalBook
      Product name: Azido-PEG4-CH2CO2-NHS ; Synonyms: N3-PEG4-CH2COONHS/Acetic acid, 2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]-, 2...
      www.chemicalbook.com
    • N3-PEG4-CH2CO2-NHS | CAS:1807534-82-2 | Biopharma PEG
      Uses： Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligan...
      Biopharma PEG
    • N3 Peg N3 - SINOPEG
      N3-PEG4-CH2CO2-NHS Cas:1807534-82-2. N3-PEG4-CH2CO2-NHS. Product Name:N3-PEG4-CH2CO2-NHS. CAS No.:1807534-82-2. M.W:374.35. Storag...
      www.sinopeg.com
    • Go to product viewer dialog for this item.
      N3-PEG4-C2-NHS ester
      N3-PEG4-C2-NHS ester is a non-degradable ADC linker containing 4 units of PEG that can be used to synthesize antibody-coupled reac...
      Google
    • N3-PEG4-SPA | CAS:944251-24-5 - Biopharma PEG
      N3-PEG4-SPA (Azido-PEG4-NHS Ester) is a heterobifunctional PEG linker containing an azide group and an NHS ester. The azide group ...
      Biopharma PEG
    • Azido-PEG-NHS ester, MW 2,000 - BroadPharm
      Azido-PEG-NHS ester, MW 2,000 (N3-PEG-SPA, MW 2,000) is a Click chemistry-reactive PEG active ester containing an azide group. Azi...
      BroadPharm
    • N3-PEG4-C2-NHS ester | ADC Linker | 944251-24-5 | AdooQ®
      N3-PEG4-C2-NHS ester is a non-cleavable 4-unit polyethylene glycol (PEG) linker designed for use in the synthesis of antibody-drug...
      Adooq Bioscience
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    N3-PEG4-CH2CO2-NHS | CAS:1807534-82-2


    Biopharma PEG
    https://www.biochempeg.com › product › N3-PEG4-CH...
    Biopharma PEG
    https://www.biochempeg.com › product › N3-PEG4-CH...
    Uses： Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis ...Read more
    $340.00 · $55 delivery

    Azido-PEG4-CH2CO2-NHS | C14H22N4O8 - PubChem - NIH


    National Institutes of Health (.gov)
    https://pubchem.ncbi.nlm.nih.gov › compound
    National Institutes of Health (.gov)
    https://pubchem.ncbi.nlm.nih.gov › compound
    Azido-PEG4-CH2CO2-NHS | C14H22N4O8 | CID 86276408 - structure, chemical names, physical and chemical properties, classification, patents, literature, ...

    N3-PEG4-C2-NHS ester | ADC Linker


    MedchemExpress.com
    https://www.medchemexpress.com › n3-peg4-c2-nhs-ester
    MedchemExpress.com
    https://www.medchemexpress.com › n3-peg4-c2-nhs-ester
    N3-PEG4-C2-NHS ester is a nonclaevable 4-unit PEG linker used in the synthesis of antibody-drug conjugates (ADCs).Read more
    4.5(1) · Free delivery · 30-day returns
    Missing: CH2CO2- ‎| Show results with: CH2CO2-

    N3-PEG4-C2-NHS ester | ADC linker


    TargetMol
    https://www.targetmol.com › ... › Cancer › ADC Linker
    TargetMol
    https://www.targetmol.com › ... › Cancer › ADC Linker
    N3-PEG4-C2-NHS ester is a non-degradable ADC linker containing 4 units of PEG that can be used to synthesize antibody-coupled reactive molecules (ADCs).
    5.0(10)
    Missing: CH2CO2- ‎| Show results with: CH2CO2-

    N3-PEG4-CH2CO2-NHS Cas:1807534-82-2


    Amerigo Scientific
    https://www.amerigoscientific.com › n3-peg4-ch2co2-n...
    Amerigo Scientific
    https://www.amerigoscientific.com › n3-peg4-ch2co2-n...
    Amerigo Scientific is a specialist distributor in serving life science that provides high quality N3-PEG4-CH2CO2-NHS Cas:1807534-82-2.

    N3-PEG4-CH2CO2-NHS Cas:1807534-82-2


    SINOPEG
    https://www.sinopeg.com › Bioorthogonal Reaction
    SINOPEG
    https://www.sinopeg.com › Bioorthogonal Reaction
    We are professional China N3-PEG4-CH2CO2-NHS company,manufacturer N3-PEG4-CH2CO2-NHS Cas:1807534-82-2 many years.All PEGs products acquired ISO-9001and ...

    Azido-PEG4-CH2CO2-NHS - Safety Data Sheet


    ChemicalBook
    https://www.chemicalbook.com › msds
    ChemicalBook
    https://www.chemicalbook.com › msds
    Product name: Azido-PEG4-CH2CO2-NHS ; Synonyms: N3-PEG4-CH2COONHS/Acetic acid, 2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester, ...

    N3-PEG4-CH2CO2-NHS | CAS:1807534-82-2


    湖南华腾制药有限公司
    https://en.huatengsci.com › product › N3-PEG4-CH2CO...
    湖南华腾制药有限公司
    https://en.huatengsci.com › product › N3-PEG4-CH2CO...
    CAS No.： 1807534-82-2 · Synonyms： Azido-PEG4-CH2CO2-NHS N3-PEG4-SCM · Purity： ≥95% · Molecular formula： C14H22N4O · Molecular weight： 374.35 · Uses：

    Azido-PEG4-CH2CO2-NHS | CAS# 1807534-82-2


    MedKoo Biosciences
    https://www.medkoo.com › products
    MedKoo Biosciences
    https://www.medkoo.com › products
    Azido-PEG4-CH2CO2-NHS is a PEG derivative containing an azide group and an NHS ester. The hydrophilic PEG spacer increases solubility in aqueous media.
    $1,250.00
    Missing: N3- ‎| Show results with: N3-

    N3 Peg N3


    SINOPEG
    https://www.sinopeg.com › n3-peg-n3_sp_6
    SINOPEG
    https://www.sinopeg.com › n3-peg-n3_sp_6
    N3-PEG4-CH2CO2-NHS Cas:1807534-82-2. N3-PEG4-CH2CO2-NHS. Product Name:N3-PEG4-CH2CO2-NHS. CAS No.:1807534-82-2. M.W:374.35. Storage:-18 ...
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