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    About 16,000 results (0.33s) 
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    An AI Overview is not available for this searchCan't generate an AI overview right now. Try again later.
    AI Overview
    High-yield production of chlortetracycline (CTC) is secured through optimized fermentation of Streptomyces aureofaciens at temperatures between
    23∘C23 raised to the composed with power C
    23∘C
     and
    25∘C25 raised to the composed with power C
    25∘C
    , utilizing specific metabolic engineering (like manipulating the CtcS regulator) to enhance efficiency. Recovery is maximized by adjusting the fermentation broth to a pH of 6–10. 
    Key Factors for High-Yield Chlortetracycline 
    • Production Mechanism: Chlortetracycline is produced via aerobic fermentation of the soil actinomycete Streptomyces aureofaciens.
    • Temperature Optimization: Maximal accumulation occurs at
      23
      --
      25∘C
      ; lower temperatures favor higher chlortetracycline yield, while higher temperatures can reduce total yield by 80–90%.
    • Genetic Regulation: Manipulating the CtcS (a MarR family regulator) can increase yield by regulating the metabolic pathway of CTC production.
    • Extraction Efficiency: Adjusting the fermentation mash pH to a range of 6-10 helps retain the antibiotic with the mycelium in the filter cake, improving recovery and purity.
    • Degradation Control: Effective management of CTC in wastewater is achieved through a combination of hydrodynamic cavitation and hydrogen peroxide, providing high-rate degradation (up to 93.8% in 30 minutes) for environmental protection. 
    Chlortetracycline is widely used as a broad-spectrum antibiotic to manage livestock diseases and improve feed efficiency in cattle and sheep. 
    • CtcS, a MarR family regulator, regulates chlortetracycline ...
      Dec 10, 2019 — Meanwhile, the target CtcS-regulated genes were identified and the CtcS-binding sequence was determined by DNase I footprinting. M...
      National Institutes of Health (.gov)
    • Chlortetracycline, purification and alkaline earth salts
      The preferred pH range for the separation is fairly broad. It depends upon the particular mash used, the concentration of chlortet...
      Google Patents
    • Effect of Temperature on the Coproduction of Chlortetracycline and ...
      Abstract. Five strains of Streptomyces aureofaciens of diverse origin and ability to incorporate chloride into chlortetracycline (
      PubMed Central (PMC) (.gov)
    • Rapid Degradation of Chlortetracycline Using Hydrodynamic ... - PMC
      Abstract. Chlortetracycline (CTC), which has been frequently detected in surface water, is generated primarily by the discharge of...
      PubMed Central (PMC) (.gov)
    • Chlortetracycline - an overview | ScienceDirect Topics
      Chlortetracycline (2) was discovered by bioprospecting for antibiotic-producing organisms and is the product of aerobic fermentati...
      ScienceDirect.com
    • CTC (Chlorotetracycline) Crumbles - Hubbard Feeds
      Jan 21, 2026 — Products. Beef. Cow and Calf. Medications. CTC (Chlorotetracycline) Crumbles. CTC (chlortetracycline) 4G Crumbles, CTC 8G Crumbles...
      Hubbard Feeds
    • CtcS, a MarR family regulator, regulates chlortetracycline ...
      Dec 10, 2019 — Meanwhile, the target CtcS-regulated genes were identified and the CtcS-binding sequence was determined by DNase I footprinting. M...
      National Institutes of Health (.gov)
    • Chlortetracycline, purification and alkaline earth salts
      The preferred pH range for the separation is fairly broad. It depends upon the particular mash used, the concentration of chlortet...
      Google Patents
    • Effect of Temperature on the Coproduction of Chlortetracycline and ...
      Abstract. Five strains of Streptomyces aureofaciens of diverse origin and ability to incorporate chloride into chlortetracycline (
      PubMed Central (PMC) (.gov)
    Show all
    Dive deeper in AI Mode
    This is for informational purposes only. For medical advice or diagnosis, consult a professional. AI responses may include mistakes. Learn more
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    Web results

    Chlortetracycline


    Anhui Techchem Industrial Co.,Ltd.
    https://www.techemi.com › chlortetracycline_p83
    Anhui Techchem Industrial Co.,Ltd.
    https://www.techemi.com › chlortetracycline_p83
    2) Mainly used for gram positive cocci and gram negative bacilli infection, also for typhus, tsutsugamushi disease and Ehrlichia infection; 3) Used as a feed ...

    CtcS, a MarR family regulator, regulates chlortetracycline ...


    National Institutes of Health (.gov)
    https://pmc.ncbi.nlm.nih.gov › articles › PMC6905112
    National Institutes of Health (.gov)
    https://pmc.ncbi.nlm.nih.gov › articles › PMC6905112
    by L Kong · 2019 · Cited by 17 — Chlortetracycline (CTC) is one of the commercially important tetracyclines (TCs) family product and is mainly produced by Streptomyces.
    People also ask
    What does CTC do for cattle?
    In beef cattle, CTC is approved to control anaplasmosis and bacterial pneumonia or to treat bacterial enteritis or pneumonia. For respiratory disease, CTC can be fed to control respiratory disease at 350 mg/head/day or to treat respiratory disease at 10 mg/lb/day.

    Feeding CTC to beef cows - Iowa State University


    Iowa State University
    https://vetmed.iastate.edu › vdpam › wp-content › uploads
    Iowa State University
    https://vetmed.iastate.edu › vdpam › wp-content › uploads
    What is chlortetracycline used for?
    An error has occurred. Please try again later.
    What is chlortetracycline eye ointment used for?
    Chlortetracycline Eye Ointment - NUHS | National University ...
    What is this medication for? Chlortetracycline eye ointment is used to treat superficial bacteria eye infection. It may also be prescribed to treat bacterial infection on open wounds on the skin.Jul 30, 2025

    Chlortetracycline Eye Ointment | National University Health System


    NUHS
    https://www.nuhs.edu.sg › patient-care › medications › c...
    NUHS
    https://www.nuhs.edu.sg › patient-care › medications › c...
    Is chlortetracycline still commonly used?
    Chlortetracycline was the first tetracycline (and thus the true prototype). However, it is no longer used clinically. A modification of tetracyclines has resulted in a new class of antibiotic called glycylcyclines (tigecycline).

    Chlortetracycline - an overview | ScienceDirect Topics


    ScienceDirect.com
    https://www.sciencedirect.com › topics › neuroscience
    ScienceDirect.com
    https://www.sciencedirect.com › topics › neuroscience

    Web results

    Chlortetracycline hydrochloride (CTC) – Medicating ...


    Agence canadienne d'inspection des aliments
    http://inspection.canada.ca › medicating-ingredients › c...
    Agence canadienne d'inspection des aliments
    http://inspection.canada.ca › medicating-ingredients › c...
    May 16, 2022 — Chlortetracycline hydrochloride (CTC) – Medicating Ingredient Brochure · Aid in the prevention of Hexamitiasis · Aid in treatment of Hexamitiasis ...Read more
    Missing: Yield ‎| Show results with: Yield

    Chlortetracycline - an overview


    ScienceDirect.com
    https://www.sciencedirect.com › medicine-and-dentistry
    ScienceDirect.com
    https://www.sciencedirect.com › medicine-and-dentistry
    Chlortetracycline is defined as an antibiotic that, when ingested, can cause permanent discoloration of teeth, resulting in a brownish-gray color due to its ...Read more
    Missing: Secures ‎| Show results with: Secures

    Chlortetracycline, purification and alkaline earth salts


    Google Patents
    https://patents.google.com › patent
    Google Patents
    https://patents.google.com › patent
    For good yields; the extraction should be repeated at least once 1 additionally; Either'the acidic or basic salts with the ammonia and alkali group are more ...Read more

    Chlortetracycline CTC Powder For Poultry Pigs Swine Feed


    Swiss Chemie
    https://www.swisschemie.com › updates › Chlortetracycli...
    Swiss Chemie
    https://www.swisschemie.com › updates › Chlortetracycli...
    Feed Grade is a broad-spectrum antimicrobial drug. It is active in the inhibition and treatment of dysentery, enteritis, pheumonia, typhoid, paratyphoid , ...Read more

    Chlortetracycline Selective Supplement for microbiology 57 ...


    Sigma-Aldrich
    https://www.sigmaaldrich.com › product › sial
    Sigma-Aldrich
    https://www.sigmaaldrich.com › product › sial
    Application. An antibiotic supplement recommended for selective isolation of Penicillium viridicatum and related species isolated from foods. ; Other Notes.Read more
    Missing: Secures ‎Yield

    Poultry Products - FARAD's Species Pages


    usfarad.org
    http://www.usfarad.org › durvet-poultry-brochure
    usfarad.org
    http://www.usfarad.org › durvet-poultry-brochure
    PDF
    Contains 64gm chlortetracycline hydrochloride per pound. 25.6oz. packet, 24 packets per case. Neomycin-325 Soluble Powder. For the treatment and control of ...Read more

    Photolysis of Chlortetracycline on a Clay Surface


    ACS Publications
    https://pubs.acs.org › doi
    ACS Publications
    https://pubs.acs.org › doi
    The underlying reasons for the lower quantum yield for clay-bound chlortetracycline are not known, but may include changes in chemical environment upon ...Read more

    CTC (Chlorotetracycline) Crumbles


    Hubbard Feeds
    https://www.hubbardfeeds.com › opticare › medications
    Hubbard Feeds
    https://www.hubbardfeeds.com › opticare › medications
    CTC (chlortetracycline) is a broad spectrum antibiotic with a variety of feeding levels for use in beef cattle, non-lactating dairy cattle, and sheep.Read more
    People also search for
    Chlortetracycline for cattle
    Chlortetracycline hydrochloride
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    Chlortetracycline pronunciation

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