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    PEG (Succinimidyl Carboxymethyl Ester)2 - JenKem
    Succinimidyl carboxymethyl ester (SCM) is a functional group used in chemical reagents, often attached to polyethylene glycol (PEG) chains, to react with primary amines on other molecules. It is a type of NHS ester that allows for amine-reactive labeling, conjugation, or modification of biomolecules, surfaces, and hydrogels in fields like drug delivery, bioconjugation, and nanotechnology. 
    Function 
    • Amine reactivity: The succinimidyl ester group reacts with primary amines (
      −NH2negative NH sub 2
      −NH2
      ), such as those found in the amino acid lysine or at the N-terminus of a protein, to form a stable amide bond.
    • Stable linker: A methylene (
      −CH2−negative CH sub 2 minus
      −CH2−
      ) linkage often connects the SCM group to the PEG chain, creating a stable linker between the PEG and the active ester group.       
    Common applications 
    • Bioconjugation: It is used to attach molecules like PEG to proteins, antibodies, or other biologics.
    • Drug delivery: SCM-modified PEGs can be used to modify and improve the properties of drug delivery systems.
    • Hydrogels: It is a component in the creation of hydrogels for biomedical applications.
    • Surface functionalization: The reagent can be used to modify surfaces for specific purposes.
    • Crosslinking: When paired with another reactive group (as in maleimide-PEG-SCM), it can act as a crosslinker, connecting two different molecules or structures. 
    Variations 
    • Polyethylene Glycol (PEG) conjugates: SCM groups are commonly found on various PEG structures, such as linear, branched, or multi-armed PEGs.
    • Heterobifunctional reagents: Some reagents contain both an SCM group and a second reactive group, such as a maleimide group that reacts with thiols, allowing for conjugation to two different types of molecules.
    • Targeted reagents: The molecule can be further modified with a targeting moiety, such as a glucose group, to increase the selectivity of the reaction. 
    • Mal-PEG-SCM, Maleimide PEG Succinimidyl Carboxymethyl Ester - Biopharma PEG
      Maleimide PEG Succinimidyl Carboxymethyl Ester (MAL-PEG-SCM) is a linear heterobifunctional PEG reagent. It has both a maleimide a...
      Biopharma PEG
    • 8-Arm PEG-SCM (SCM: Succinimidyl Carboxymethyl ester)
      Description. 8-Arm PEG-SCM is a multiarmed PEG derivative with succinimidyl NHS ester groups at each terminal of the eight arms co...
      Creative PEGWorks
    • mPEG40K-Succinimidyl Carboxymethyl Ester ... - Sigma-Aldrich
      Description * General description. Methoxy PEG NHS Ester (SCM PEG). Amine reactive PEG towards the amino groups of lysine(s) on pr...
      Sigma-Aldrich
    • Glucose PEG Succinimidyl Carboxymethyl Ester
      Description. Glucose PEG Succinimidyl Carboxymethyl Ester is a high quality amine reactive PEG product with a succinimidyl carboxy...
      glycodepot.com
    • mPEG-SCM - Abbexa Ltd
      Methoxy PEG Succinimidyl Carboxymethyl Ester (Methoxy PEG NHS or Methoxy PEG SCM) is a high quality amine reactive PEG product wit...
      Abbexa
    • Maleimide-PEG-SCM (Maleimide-PEG-succinimidyl carboxy methyl) - Cepham Life Sciences Research Products
      Maleimide-PEG-SCM (maleimide-PEG-succinimidyl carboxymethyl ester) is a linear heterobifunctional PEG derivative. It has one malei...
      Cepham Life Sciences
    • 4-arm Poly(ethylene glycol) succinimidyl carboxymethyl ester ...
      4-arm Poly(ethylene glycol) succinimidyl carboxymethyl ester (4-arm PEG-SCM) manufactured by SINOPEG is a high quality multi-arm P...
      SINOPEG
    • Mal-PEG-SCM, Maleimide PEG Succinimidyl Carboxymethyl Ester - Biopharma PEG
      Maleimide PEG Succinimidyl Carboxymethyl Ester (MAL-PEG-SCM) is a linear heterobifunctional PEG reagent. It has both a maleimide a...
      Biopharma PEG
    • 8-Arm PEG-SCM (SCM: Succinimidyl Carboxymethyl ester)
      Description. 8-Arm PEG-SCM is a multiarmed PEG derivative with succinimidyl NHS ester groups at each terminal of the eight arms co...
      Creative PEGWorks
    • mPEG40K-Succinimidyl Carboxymethyl Ester ... - Sigma-Aldrich
      Description * General description. Methoxy PEG NHS Ester (SCM PEG). Amine reactive PEG towards the amino groups of lysine(s) on pr...
      Sigma-Aldrich
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    mPEG40K-Succinimidyl Carboxymethyl Ester average ...


    Sigma-Aldrich
    https://www.sigmaaldrich.com › aldrich › jka3041
    Sigma-Aldrich
    https://www.sigmaaldrich.com › aldrich › jka3041
    mPEG40K average Mn 40000, Succinimidyl Carboxymethyl Ester, amine reactive Synonyms: mPEG-Succinimidyl Carboxymethyl Ester,Polyethylene glycol; ...
    $621.00 · $23.16 delivery

    Mal-PEG-SCM, Maleimide PEG Succinimidyl ...


    Biopharma PEG
    https://www.biochempeg.com › product › Mal-PEG-SCM
    Biopharma PEG
    https://www.biochempeg.com › product › Mal-PEG-SCM
    Maleimide PEG Succinimidyl Carboxymethyl Ester (MAL-PEG-SCM) is a linear heterobifunctional PEG reagent featuring both a maleimide and a succinimidyl NHS ester ...
    $55 delivery

    8-Arm PEG-SCM (SCM: Succinimidyl Carboxymethyl ester)


    Creative PEGWorks
    https://creativepegworks.com › Products
    Creative PEGWorks
    https://creativepegworks.com › Products
    PEG-SCM (succinimidyl carboxyl methyl ester) is one type of PEG-NHS reagents. There is a methylene (CH2) linkage between PEG and the NHS ester.
    Free delivery

    mPEG20K-Succinimidyl Carboxymethyl Ester average ...


    Sigma-Aldrich
    https://www.sigmaaldrich.com › aldrich › jka3003
    Sigma-Aldrich
    https://www.sigmaaldrich.com › aldrich › jka3003
    General description. Methoxy PEG NHS Ester (SCM PEG). Amine reactive PEG towards the amino groups of lysine(s) on proteins or other biologics; reaction occurs ...
    $492.00 · $23.16 delivery

    4arm PEG Succinimidyl Carboxymethyl Ester


    JenKem Technology USA
    https://jenkemusa.com › product › 4arm-peg-succinimi...
    JenKem Technology USA
    https://jenkemusa.com › product › 4arm-peg-succinimi...
    JenKem Technology's 4arm PEG Succinimidyl Carboxymethyl Ester (4arm NHS PEG) derivatives can be cross-linked into PEG hydrogels.
    $110.00 to $960.00

    Methoxy PEG Succinimidyl Carboxymethyl Ester, MW 5K


    AxisPharm
    https://axispharm.com › ... › Active ester › m-PEG-SCM
    AxisPharm
    https://axispharm.com › ... › Active ester › m-PEG-SCM
    Methoxy PEG Succinimidyl Carboxymethyl Ester (mPEG-SCM), MW 5K CAS:92451-01-9 is a monomethoxy polyethylene glycol (mPEG) modifier with a stable non-degradable ...
    $230.00 to $880.00 · 30-day returns

    Methoxy PEG Succinimidyl Carboxymethyl Ester 2000


    Santa Cruz Biotechnology
    https://www.scbt.com › ... › Other Chemicals 0149
    Santa Cruz Biotechnology
    https://www.scbt.com › ... › Other Chemicals 0149
    Buy Methoxy PEG Succinimidyl Carboxymethyl Ester 2000 (CAS 25322-68-3), a biochemical for proteomics research, from Santa Cruz. , MW: 2000.

    Glucose PEG Succinimidyl Carboxymethyl Ester


    glycodepot.com
    https://glycodepot.com › Shop
    glycodepot.com
    https://glycodepot.com › Shop
    Glucose PEG Succinimidyl Carboxymethyl Ester is a high quality amine reactive PEG product with a succinimidyl carboxymethyl ester active group and a targeting ...
    $99.10 to $999.10 · $60 delivery

    4-arm Poly(ethylene Glycol) Succinimidyl Carboxymethyl ...


    SINOPEG
    https://www.sinopeg.com › 4-arm PEG
    SINOPEG
    https://www.sinopeg.com › 4-arm PEG
    A high quality multi-arm PEG derivative with succinimidyl carboxymethyl ester at each terminal of the four arms connected to one pentaerythritol core.

    4arm-PEG10K-Succinimidyl Carboxymethyl Ester average ...


    Sigma-Aldrich
    https://www.sigmaaldrich.com › aldrich › jka7015
    Sigma-Aldrich
    https://www.sigmaaldrich.com › aldrich › jka7015
    4arm-PEG10K average MN 10000, Succinimidyl Carboxymethyl Ester, amine reactive Synonyms: 4arm-PEG-Succinimidyl Carboxymethyl Ester,4arm-PEG-SCM,Polyethylene ...
    $559.00 · $23.16 delivery

    Scholarly articles for succinimidyl carboxymethyl ester

    … —carboxymethylindocyanine succinimidyl esters - ‎Southwick - Cited by 396
    … 4-arm-polyethylene-succinimidyl-carboxymethyl ester … - ‎Yadav - Cited by 8
    … niger and its hydrolysis of succinimide esters - ‎Xiaoming - Cited by 14

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