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    AI Overview

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    AI Overview
    Liraglutide's side chain is
    a palmitoyl group (a C16 fatty acid) linked to a γ-glutamic acid spacer, which is then attached to the lysine at position 20 of the peptide. This fatty acid side chain allows the drug to bind to albumin in the blood, which prolongs its half-life and enables it to be administered once daily. 
    Key components of the side chain 
    • Palmitoyl group: A 16-carbon fatty acid chain.
    • γ-Glutamic acid spacer: This is the intermediate molecule that connects the palmitoyl group to the peptide.
    • Lysine 20: The specific amino acid in the liraglutide peptide where the side chain is attached. 
    Function of the side chain 
    • Albumin binding: The fatty acid portion of the side chain allows liraglutide to bind to albumin, the main protein in blood plasma.
    • Prolonged half-life: This binding creates a reservoir of the drug in the body, preventing it from being eliminated quickly and extending its half-life to approximately 13 hours.
    • Once-daily dosing: The extended half-life is what makes a once-daily injection schedule possible for managing type 2 diabetes and obesity. 
    • Long Acting GLP-1 Receptor Agonist Drugs Lists and Overview
      Nov 11, 2021 — The albumin-bound bulk forms a reservoir promoting prolonged action. Overall, the elimination half-life is approximate...
      Biopharma PEG
    • (D-His1)-Liraglutide - GLP1 receptor agonist
      Structure of (D-His1)-Liraglutide Peptide. (D-His1)-Liraglutide is a 31-amino-acid peptide analogue of liraglutide and, therefore,
      JPT Peptide Technologies
    • Pal-Glu(OSu)-OH | Liraglutide Side Chain | MedChemExpress
      Pal-Glu(OSu)-OH is a side chain of Liraglutide. Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that can be used...
      MedchemExpress.com
    • Characterizing the D-Amino Acid Position in Peptide Epimers ... - MDPI
      Jan 23, 2024 — 2. Results * 2.1. Analytical Procedure. Liraglutide contains thirty-one amino acids (1-HAEGTFTSDVSSYLEGNAAKEFIAWLVRGRG...
      MDPI
    • Liraglutide API Manufacturer & Supplier - Bachem
      Oct 25, 2022 — Liraglutide is a long-acting peptide analog of GLP-1, because of a better resistance to DDP-IV-mediated degradation du...
      Bachem
    • Liraglutide (subcutaneous route) - Side effects & dosage - Mayo Clinic
      Jul 31, 2025 — Description. Liraglutide injection is used with diet and exercise to lower blood sugar in people with type 2 diabetes.
      Mayo Clinic
    • Lipid regulation of the glucagon receptor family in: Journal of Endocrinology Volume 261 Issue 3 (2024)
      MEDI0382 and SAR425899 are both palmitoylated with a 16-carbon palmitic acid with a γ-carboxylate spacer at lysine 10 and 14, resp...
      Journal of Endocrinology
    • Long Acting GLP-1 Receptor Agonist Drugs Lists and Overview
      Nov 11, 2021 — The albumin-bound bulk forms a reservoir promoting prolonged action. Overall, the elimination half-life is approximate...
      Biopharma PEG
    • (D-His1)-Liraglutide - GLP1 receptor agonist
      Structure of (D-His1)-Liraglutide Peptide. (D-His1)-Liraglutide is a 31-amino-acid peptide analogue of liraglutide and, therefore,
      JPT Peptide Technologies
    • Pal-Glu(OSu)-OH | Liraglutide Side Chain | MedChemExpress
      Pal-Glu(OSu)-OH is a side chain of Liraglutide. Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that can be used...
      MedchemExpress.com
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    Pal-Glu(OSu)-OH | Liraglutide Side Chain


    MedchemExpress.com
    https://www.medchemexpress.com › pal-glu-osu-oh
    MedchemExpress.com
    https://www.medchemexpress.com › pal-glu-osu-oh
    Pal-Glu(OSu)-OH is a side chain of Liraglutide. Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that can be used for type 2 diabetes mellitus ...
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    Liraglutide Side Chain [Pal-Glu(OSu)-OtBu] Cas:204521- ...


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    SINOPEG
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    Liraglutide is made by attaching a C-16 fatty acid (palmitic acid) with a glutamic acid spacer on the remaining lysine residue at position 26 of the peptide ...
    Liraglutide Side Chain from www.sinopeg.com
    Images
    Liraglutide Side Chain [Pal-Glu(OSu)-OtBu] Cas:204521-63-1 ...
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    The structures of fatty acid side chains of liraglutide and ...
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    ResearchGate
    α-Glu(side chain)-Liraglutide
    α-Glu(side chain)-Liraglutide
    Daicel Pharma Standards
    PDB-101: Diabetes Mellitus: Diabetes Mellitus: undefined ...
    PDB-101: Diabetes Mellitus: Diabetes Mellitus: undefined ...
    PDB-101 - RCSB PDB
    α-Glu(side chain)-Liraglutide
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    α-Glu(side chain)-Liraglutide - Daicel Pharma Standards
    α-Glu(side chain)-Liraglutide - Daicel Pharma Standards
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    The structures of fatty acid side chains of liraglutide and ...
    The structures of fatty acid side chains of liraglutide and ...
    ResearchGate
    WO2020182227A1 - Preparation method for high purity ...
    WO2020182227A1 - Preparation method for high purity ...
    Google Patents
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    Liraglutide | C172H265N43O51 | CID 16134956 - PubChem


    National Institutes of Health (.gov)
    https://pubchem.ncbi.nlm.nih.gov › compound › Liragl...
    National Institutes of Health (.gov)
    https://pubchem.ncbi.nlm.nih.gov › compound › Liragl...
    Liraglutide is a lipopeptide that is an analogue of human GLP-1 in which the lysine residue at position 27 is replaced by arginine and a hexadecanoyl group.

    The structures of fatty acid side chains of liraglutide and ...


    ResearchGate
    https://www.researchgate.net › figure › The-structures-o...
    ResearchGate
    https://www.researchgate.net › figure › The-structures-o...
    These include significant reductions in body weight, improvements in lipid profiles, decreased blood pressure, and attenuation of hepatic steatosis. Emerging ...
    Liraglutide Side Chain from www.researchgate.net

    α-Glu(side chain)-Liraglutide


    Daicel Pharma Standards
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    Preparation method for high purity liraglutide side chain


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    Google Patents
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    The preparation method for high purity liraglutide side chain has a simple operation, a short synthesis cycle, low costs and easy post-processing.

    Peptide Blockbusters Liraglutide and Semaglutide


    Iris Biotech GmbH
    https://iris-biotech.de › global › blog › peptide-blockbu...
    Iris Biotech GmbH
    https://iris-biotech.de › global › blog › peptide-blockbu...
    Apr 6, 2022 — Both are long-acting analogs of the linear glucagon-like peptide-1 (GLP-1) modified with a fatty acid side chain to be more stable against ...

    (D-His1)-Liraglutide - GLP1 receptor agonist


    JPT Peptide Technologies
    https://www.jpt.com › SP-CAT-036
    JPT Peptide Technologies
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    It retains liraglutide's overall structure, including the C16 palmitic acid side chain attached via a γ-glutamic acid spacer to Lys26, which promotes ...
    $978.00

    Glucagon-like peptide-1 receptor: mechanisms and ...


    Nature
    https://www.nature.com › ... › review articles
    Nature
    https://www.nature.com › ... › review articles
    by Z Zheng · 2024 · Cited by 526 — Liraglutide has an arginine at position 34 (GLP-1(7-37)) that is lysine, and its lysine at position 26 connects to a 16-carbon palmitic acid ...
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