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A multiplexing endoscopic guide beam refers to advanced optical systems that combine multiple laser or light wavelengths into a single fiber to perform simultaneous illumination, structural guidance, and functional imaging inside the body. This technology is widely used in Raman endoscopy and multi-spectral fluorescence imaging.

How It Works

Wavelength Division Multiplexing (WDM): The system injects several distinct wavelengths of light (e.g., excitation and depletion lasers) into the same optical fiber.
Multimodal Delivery: Rather than using multiple separate probes, it delivers a single integrated guide beam that handles imaging, precise surgical targeting, and molecular analysis at the same time.
Spectral Unmixing: Return signals are filtered or spectrally unmixed at the sensor, allowing doctors to view multiple biomarkers, distinct tissue depths, or multiple fields of view concurrently.

Multiplexed Molecular Imaging: Employs targeted SERS (Surface-Enhanced Raman Scattering) nanoparticles or quantum dots. The multiplexed beam excites these particles, enabling doctors to distinguish between healthy and precancerous tissues or identify flat lesions that are often missed.
Confocal and Fluorescence Endoscopy: Allows simultaneous visualization of multiple fluorophores (e.g., GFP and Texas Red) using a single illumination and optical assembly.
Advanced Microscopy Integration: Helps drive super-resolution techniques (like STED microscopy) in miniature or on-chip endoscopes by directing both pump and donut beams through a single metalens.

PNAS
A Raman-based endoscopic strategy for multiplexed molecular ...
May 23, 2013 — This device is ideally suited for detection of functionalized surface-enhanced Raman scattering (SERS) nanoparticles as molecular ...
PubMed Central (PMC) (.gov)
A Raman-based endoscopic strategy for multiplexed molecular imaging - PMC
A Raman endoscope is a noncontact, fiber optic-based device that can provide real-time, multiplexed functional information during ...
National Institutes of Health (.gov)
Spectral Multiplexing of Fluorescent Endoscopy for Simultaneous ...
Dec 27, 2022 — In this study, an endoscopic system is proposed which enables simultaneous visualization from multiple locations via spectral mult...

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Web results

Multiplexing type endoscopic guide beam

Nanjing Hecho Technology CO.,Ltd

https://www.gohecho.com › multiplexing-type-endosco...

Nanjing Hecho Technology CO.,Ltd

https://www.gohecho.com › multiplexing-type-endosco...

Worry for custom Multiplexing type endoscopic guide beam? Right here! HECHO is a leading provider of Fiber Optic products and solutions.

A Raman-based endoscopic strategy for multiplexed ... - PMC

PubMed Central (PMC) (.gov)

https://pmc.ncbi.nlm.nih.gov › articles › PMC3690865

PubMed Central (PMC) (.gov)

https://pmc.ncbi.nlm.nih.gov › articles › PMC3690865

by CL Zavaleta2013Cited by 279 — A singlet lens is used for dual purposes: to collimate the outgoing illumination beam and to collect the incoming SERS signals onto the multimode fibers.Read more

Spectral Multiplexing of Fluorescent Endoscopy for ...

MDPI

https://www.mdpi.com › ...

MDPI

https://www.mdpi.com › ...

by B Paulson2022Cited by 7 — An endoscopic system is proposed which enables multiple fluorescence microendoscopes to be spectrally multiplexed on a single microscope base.Read more

A Real-Time Clinical Endoscopic System for Intraluminal ...

PLOS

https://journals.plos.org › plosone › article › journal.po...

PLOS

https://journals.plos.org › plosone › article › journal.po...

by E Garai2015Cited by 146 — This device enables rapid circumferential scanning of topologically complex luminal surfaces of hollow organs (eg, colon and esophagus) and produces ...Read more

Wide-field endoscope accessory for multiplexed ...

Nature

https://www.nature.com › scientific reports › articles

Nature

https://www.nature.com › scientific reports › articles

by G Li2023Cited by 8 — A wide-field endoscope that is sensitive to fluorescence can be used as an adjunct to conventional white light endoscopy by detecting multiple molecular ...Read more

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Endoscopic guide beam

gohecho

https://www.gohecho.com › endoscopic-guide-beam

gohecho

https://www.gohecho.com › endoscopic-guide-beam

1 results found for "Endoscopic guide beam". Multiplexing type endoscopic guide beam. · High-quality imported optical fiber raw materials · ...

US10973399B2 - Light source device for endoscope

Google Patents

https://patents.google.com › patent

Google Patents

https://patents.google.com › patent

various types of scanning type endoscopes which guide, through an optical fiber, a laser beam generated by a light source device and scan with the laser ...

Multiplexed endoscopic imaging of Barrett's neoplasia using ...

Gut Journal

https://gut.bmj.com › content

Gut Journal

https://gut.bmj.com › content

by J Chen2021Cited by 47 — We demonstrate a multiplexed fluorescence imaging approach to detect premalignant lesions with two fluorescently labeled heptapeptides specific for EGFR and ...Read more

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Portable system for flexible micro-endoscopy using a multi- ...

SPIE Digital Library

https://www.spiedigitallibrary.org › 1.APN.5.2.026011.full

SPIE Digital Library

https://www.spiedigitallibrary.org › 1.APN.5.2.026011.full

by SP Mekhail2026 — Advances in imaging through a single multi-mode fiber (MMF) have made it a strong competitor to conventional endoscopic imaging technologies.Read more

Wide-field high-speed space-division multiplexing optical ...

Optica Publishing Group

https://opg.optica.org › boe › abstract