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α-Tert butyloxycarbonyl amino-ω-amino poly(ethylene glycol) (Boc-NH-PEG-NH2) is a heterobifunctional PEG linker featuring a Boc-protected amine at one end and a free, reactive primary amine at the other. Available in various molecular weights (e.g., 2K, 5K, 10K, 20K Da), it is crucial for selective PEGylation, antibody-drug conjugates (ADCs), and peptide synthesis.
Key Features and Applications
- Structure: Boc-NH-PEG-NH2.
- Functionality: The Boc group protects one amine (acid-labile, removed by TFA), while the free amine remains reactive towards carboxylic acids, NHS esters, and aldehydes.
- Molecular Weights: Common sizes include 2 kDa, 5 kDa, 10 kDa, and 20 kDa.
- Applications: Used in linear block copolymers, biomedical research, and pharmaceutical PEGylation to improve solubility and stability.
- Suppliers: Sinopeg, Iris Biotech GmbH, and Amerigo Scientific offer various Mw options.
The Boc group is robust in basic conditions but allows for selective deprotection in acidic environments to reveal the primary amine, making this compound a highly versatile reagent in PEGylation and drug delivery systems.
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Web results
α-Tert butyloxycarbonyl amino-ω-amino poly(ethylene glycol) ...
Amerigo Scientific
https://www.amerigoscientific.com › tert-butyloxycarbo...
Amerigo Scientific
https://www.amerigoscientific.com › tert-butyloxycarbo...
α-Tert butyloxycarbonyl amino-ω-amino poly(ethylene glycol) [Boc-NH-PEG-NH2] ; Catalog Number: PG01410410SIN ; Mfr. No.: 6020314325 ; Price: Inquiry.
Tert Butyloxycarbonyl Amino Amino Poly Ethylene Glycol
SINOPEG
https://www.sinopeg.com › tert-butyloxycarbonyl-amin...
SINOPEG
https://www.sinopeg.com › tert-butyloxycarbonyl-amin...
α-Tert butyloxycarbonyl amino-ω-carboxyl poly(ethylene glycol). Molecular Weight: 2KDa, 5KDa, 10KDa, 20KDa. Package Size: 1g/bottle, 10g/bottle, 100g/bottle.
Boc-NH-PEG-NH2 (5 kDa)
Iris Biotech GmbH
https://iris-biotech.de › global › peg1069
Iris Biotech GmbH
https://iris-biotech.de › global › peg1069
Boc-NH-PEG-NH2 (5 kDa). Chemical name: alpha-t-Butyloxycarbonylamino-omega-amino poly(ethylene glycol) // Synonyms: Boc-NH-PEG(5 kDa)-NH2.Read more
€230.00
Missing: butyloxycarbonyl ω-
α-Tert butyloxycarbonyl amino-ω-carboxyl poly(ethylene glycol) ...
Amerigo Scientific
https://www.amerigoscientific.com › tert-butyloxycarbo...
Amerigo Scientific
https://www.amerigoscientific.com › tert-butyloxycarbo...
α-Tert butyloxycarbonyl amino-ω-carboxyl poly(ethylene glycol) [Boc-NH-PEG-COOH] Cas:142929-49-5 ; Catalog Number: PG01410411SIN ; Mfr. No.: 6020314464 ; Price:.
PEGylated bioreducible poly(amido amine)s for non-viral ...
ScienceDirect.com
https://www.sciencedirect.com › article › abs › pii
ScienceDirect.com
https://www.sciencedirect.com › article › abs › pii
by C Lin2011Cited by 41 — ... α-tert-butoxycarbonylamino-ω-amino-terminated poly(ethylene glycol) (BocNH-PEG-NH2) (3.0 kDa, Aldrich) were purchased in the highest purity and used without ...Read more
Boc-NH-PEG-NH2 Manufacturer
SINOPEG
https://www.sinopeg.com › boc-nh-peg-nh2_p459
SINOPEG
https://www.sinopeg.com › boc-nh-peg-nh2_p459
We are professional China α-Tert butyloxycarbonyl amino-ω-amino poly(ethylene glycol) company,manufacturer Boc-NH-PEG-NH2 many years.
ALPHA-AMINO-OMEGA-BOC-AMINO-DODECAE(ETHYLENE ...
ChemicalBook
https://www.chemicalbook.com › ChemicalProductProp...
ChemicalBook
https://www.chemicalbook.com › ChemicalProductProp...
Chemical Name: ALPHA-AMINO-OMEGA-BOC-AMINO-DODECAE(ETHYLENE GLYCOL) ; CBNumber: CB8427032 ; Molecular Formula: C29H60N2O13 ; Molecular Weight: 644.79 ; MOL File: ...
Modular Approach to the Functionalization of Polymersomes
PubMed Central (PMC) (.gov)
https://pmc.ncbi.nlm.nih.gov › articles › PMC7218747
PubMed Central (PMC) (.gov)
https://pmc.ncbi.nlm.nih.gov › articles › PMC7218747
by SJ Rijpkema2020Cited by 29 — α-Amine-poly(ethylene glycol)-b-polylactic acid-TBS (7). Polymer product 6 (7.5 g, 0.5 mmol, 1 equiv) was dissolved in dry DCM (20 mL) and degassed for 15 min.Read more
Poly(ethylene oxide) or poly(ethylene glycol), other ...
Polymer Source
https://www.polymersource.ca › category
Polymer Source
https://www.polymersource.ca › category
Poly(ethylene glycol), (α-butoxycarbonylamino [BOC], ω-hydroxy)-terminated .21. Poly(ethylene oxide), α,ω-bis(cholesterol)-terminated .22. Poly(ethylene ...Read more
People also ask
Is peg toxic to cells?
PEGs are non-toxic, FDA-approved, generally nonimmunogenic, and are frequently used in many biomedical applications including bioconjugation,1 drug delivery,2,3 surface functionalization,4 and tissue engineering.
Polyethylene Glycol (PEG) Selection Guide
Sigma-Aldrich
https://www.sigmaaldrich.com › drug-delivery › polyeth...
Sigma-Aldrich
https://www.sigmaaldrich.com › drug-delivery › polyeth...
Web results
ɑ-Amino-ω-Boc Amino PEG
Rapp Polymere
https://www.rapp-polymere.com › heterobifunctional-pegs
Rapp Polymere
https://www.rapp-polymere.com › heterobifunctional-pegs
PEG crosslinkers with Boc (tert-butyloxycarbonyl)-protected amino groups on one chain end. The Boc protecting group is stable in a wide range of conditions ...