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Acalabrutinib Intermediate N-1 is

a chemical compound used in the synthesis of the cancer drug acalabrutinib, which is a Bruton's tyrosine kinase inhibitor. Its chemical name is 4-[8-Amino-3-(2S)-2-pyrrolidinylimidazo[5-a]pyrazin-1-yl]-N-2-pyridinylbenzamide, and its CAS number is 1420478-90-5. It is an intermediate product in the manufacturing process of acalabrutinib and is used to produce the final active pharmaceutical ingredient (API).

Function: Acalabrutinib Intermediate N-1 is a building block used in a multi-step process to create acalabrutinib.
Drug: Acalabrutinib is a medication used to treat certain types of leukemia, such as chronic lymphocytic leukemia (CLL) and mantle cell lymphoma.
Mechanism: It works by blocking the Bruton's tyrosine kinase (BTK) enzyme, which is crucial for the survival and growth of B-cells.
Synthesis: The intermediate is a key part of the chemical synthesis of acalabrutinib, with various companies manufacturing it for pharmaceutical companies, as reported by MedKoo Biosciences, LookChem, and ChemicalBook.

Acalabrutinib Intermediate | 1420478-90-5 - ChemicalBook
Jul 3, 2025 — Acalabrutinib Intermediate. 1420478-90-5. US $0.00 / kg. 99% Shaanxi Dideu New Materials Co. Ltd. 4-[8-Amino-3-(2S)-2-p...
ChemicalBook
Acalabrutinib N-1 CAS No.1420478-90-5 - LookChem
Acalabrutinib Synthetic Routes - MedKoo Biosciences
Description: Acalabrutinib, also known as ACP-196, is an orally available inhibitor of Bruton's tyrosine kinase (BTK) with potenti...
MedKoo Biosciences

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Acalabrutinib Intermediate | 1420478-90-5

ChemicalBook

https://www.chemicalbook.com › ... › CAS DataBase List

ChemicalBook

https://www.chemicalbook.com › ... › CAS DataBase List

Jul 4, 2025 — Acalabrutinib Intermediate (CAS 1420478-90-5) information, including chemical properties, structure, melting point, boiling point, density, ...

Acalabrutinib Intermediate N-1 from www.chemicalbook.com

CAS 1420478-88-1 Acalabrutinib Intermediate ...

Aarti Pharmalabs Limited

https://www.aartipharmalabs.com › acalabrutinib-interme...

Aarti Pharmalabs Limited

https://www.aartipharmalabs.com › acalabrutinib-interme...

API Name, Acalabrutinib Intermediate ; Intermediate Name, (2S)-2-(8-amino-1-bromoimidazo[1,5-a] pyrazin-3-yl)-1-Pyrrolidine carboxylic acid phenyl methyl ester.

Acalabrutinib Intermediate N-1 from www.aartipharmalabs.com

Best Acalabrutinib Intermediate CAS No.1420478-90-5 ...

Afine Chemicals Limited

https://www.afinechem.com › acalabrutinib-intermediate-...

Afine Chemicals Limited

https://www.afinechem.com › acalabrutinib-intermediate-...

Acalabrutinib Intermediate is a crucial component in the synthesis of Acalabrutinib, a targeted cancer therapy used to treat various types of B-cell ...

Acalabrutinib Intermediate N-1 from www.afinechem.com

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Process for the preparation of acalabrutinib and its ...

Google Patents

https://patents.google.com › patent

Google Patents

https://patents.google.com › patent

The present invention provides an improved and industrially viable process for the preparation of Acalabrutinib and its intermediates in high yield.

Acalabrutinib Intd1/ 1418307-17-1

Hangzhou Longshine Bio-Tech Co.,LTD

https://www.longshinebiotech.com › ... › Intermediates

Hangzhou Longshine Bio-Tech Co.,LTD

https://www.longshinebiotech.com › ... › Intermediates

... 1 intermediate with reliable quality and good price ... Cas No.: 1418307-17-1. Molecular Formula: C18H19ClN4O3. Molecular Weight: 375. Purity 99%. Quality ...

Acalabrutinib Intermediate 1 cas 1420478-88-1

Taizhou Crene Biotechnology Co., Ltd.

http://www.pharm-intermediates.com › detail_1420478...

Taizhou Crene Biotechnology Co., Ltd.

http://www.pharm-intermediates.com › detail_1420478...

Product name：Acalabrutinib Intermediate 1, Purity：98% min ; CAS NO：1420478-88-1, Solubility：Soluble in DMSO ; Molecular Formula：C18H18BrN5O · Package：Package ...

Ion Trap LC/MS reveals the generation of reactive ...

National Institutes of Health (NIH) | (.gov)

https://pubmed.ncbi.nlm.nih.gov › ...

National Institutes of Health (NIH) | (.gov)

https://pubmed.ncbi.nlm.nih.gov › ...

by AM Alsibaee2024 — Acalabrutinib (CALQUENCE; ACB) is a Bruton tyrosine kinase inhibitor (BTKI) used to treat mantle cell lymphoma, small lymphocytic lymphoma ...

Missing: N- ‎| Show results with: N-

Acalabrutinib Intermediate 1 cas1420478-88-1

Cyanochem

http://www.cyanochem.com › product

Cyanochem

http://www.cyanochem.com › product

Cat.No. RS20096; Name: Acalabrutinib Intermediate 1; CAS: 1420478-88-1; MF: C18H18BrN5O2; MW: 416.27. Product Detail. Chemical Name, Acalabrutinib ...

High-Purity Pharmaceutical Intermediate for Acalabrutinib ...

NINGBO INNO PHARMCHEM CO.,LTD.

https://www.nbinno.com › Pharmaceuticals

NINGBO INNO PHARMCHEM CO.,LTD.

https://www.nbinno.com › Pharmaceuticals

Oct 27, 2025 — This high-purity pharmaceutical intermediate is essential for the synthesis of Acalabrutinib, a vital drug in cancer therapy. With purity ...

(S)-4-(8-Amino-3-pyrrolidin-2-yl-imidazo[1,5-a]pyrazin- ...

china-sinoway.com

https://www.china-sinoway.com › s-4-8-amino-3-pyrrol...