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    AI Overview
    Insulin Detemir Side Effects: Onset, Peak, Duration Guide
    Insulin detemir is a long-acting insulin analog characterized by a 14-carbon fatty acid side chain, myristic acid, attached to the lysine amino acid at position B29. This modification, along with the deletion of threonine at B30, enables the insulin to bind to albumin in the bloodstream, providing a slow, prolonged absorption and a 16-24 hour duration of action. 
    Key Features of the Detemir Side Chain: 
    • Structure: The side chain is a myristoyl group (a 14-carbon fatty acid,
      C14cap C sub 14
      𝐶14
      ).
    • Attachment Point: It is acylated (linked) to the
      ϵepsilon
      𝜖
      -amino group of the Lysine residue at position B29 of the insulin B-chain.
    • Modification: The threonine amino acid at position B30 is removed (deletion of B30).
    • Mechanism of Action: The fatty acid chain enables two main mechanisms for extending action:
      1. Albumin Binding: It promotes reversible binding to albumin in the subcutaneous tissue and blood, delaying absorption.
      2. Self-Association: It increases the self-association of insulin molecules into hexamers at the injection site, further slowing release. 
    Functional Advantages: 
    • Long-Acting: It acts as a basal insulin with a stable, flat pharmacokinetic profile.
    • Less Variability: The albumin-bound mechanism results in lower intrapatient variability in absorption compared to other insulins. 
    Note: For specialized, technical information on the manufacturing component, see this Insulin Detemir Side Chain [Myr-OSu] Manufacturer site (SINOPEG). 
    • Insulin Detemir - an overview | ScienceDirect Topics
      In insulin detemir, tyrosine at position B30 is lost with acylation at B29 that results in a fatty acid side chain (tetradecanoic ...
      ScienceDirect.com
    • Insulin Detemir - an overview | ScienceDirect Topics
      General Information. Insulin detemir is a long-acting insulin analogue that lacks threonine at the B30 position and is acylated wi...
      ScienceDirect.com
    • Insulin detemir: Uses, Interactions, Mechanism of Action
      Jun 30, 2007 — The myristic acid side chain on insulin detemir increases self-association and gives it a high binding affinity to serum albumin. ...
      DrugBank
    • Insulin Detemir | C267H402N64O76S6 | CID 16137271 - PubChem
      This insulin analogue has a 14-C fatty acid, myristic acid, bound to the lysine amino acid at position B29. The myristoyl side cha...
      National Institutes of Health (.gov)
    • Critical appraisal of the safety and efficacy of insulin detemir in ...
      Insulin detemir has a very different protraction principle. There is deletion of the terminal B chain amino acid (B30), and a fatt...
      National Institutes of Health (.gov)
    • Structure of insulin detemir.
      This information does not constitute medical advice or diagnosis. Insulin detemir is a soluble, long-acting human insulin analogue...
      ResearchGate
    • Pharmacology of insulin detemir - PubMed
      Aug 15, 2007 — Abstract. Insulin detemir (Levemir [Novo Nordisk A/S, Bagsvaerd, Denmark]) is a soluble, long-acting basal insulin analog. It diff...
      National Institutes of Health (.gov)
    • What is the mechanism of Insulin detemir? - Patsnap Synapse
      Jul 17, 2024 — These pathways promote glucose uptake in muscle and fat cells and inhibit glucose production in the liver, leading to a reduction ...
      Patsnap Synapse
    • Insulin Detemir - an overview | ScienceDirect Topics
      In insulin detemir, tyrosine at position B30 is lost with acylation at B29 that results in a fatty acid side chain (tetradecanoic ...
      ScienceDirect.com
    • Insulin Detemir - an overview | ScienceDirect Topics
      General Information. Insulin detemir is a long-acting insulin analogue that lacks threonine at the B30 position and is acylated wi...
      ScienceDirect.com
    • Insulin detemir: Uses, Interactions, Mechanism of Action
      Jun 30, 2007 — The myristic acid side chain on insulin detemir increases self-association and gives it a high binding affinity to serum albumin. ...
      DrugBank
    Show all
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    Web results

    Insulin detemir: Uses, Interactions, Mechanism of Action


    DrugBank
    https://go.drugbank.com › drugs
    DrugBank
    https://go.drugbank.com › drugs
    Jun 30, 2007 — The myristic acid side chain on insulin detemir increases self-association and gives it a high binding affinity to serum albumin. These ...Read more

    Insulin Detemir - an overview


    ScienceDirect.com
    https://www.sciencedirect.com › topics › neuroscience › i...
    ScienceDirect.com
    https://www.sciencedirect.com › topics › neuroscience › i...
    In insulin detemir, tyrosine at position B30 is lost with acylation at B29 that results in a fatty acid side chain (tetradecanoic acid) becoming linked with ...Read more
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    Web results

    Critical appraisal of the safety and efficacy of insulin detemir in ...


    National Institutes of Health (.gov)
    https://pmc.ncbi.nlm.nih.gov › articles › PMC3047990
    National Institutes of Health (.gov)
    https://pmc.ncbi.nlm.nih.gov › articles › PMC3047990
    by JP Le Floch · 2010 · Cited by 16 — Insulin detemir has a very different protraction principle. There is deletion of the terminal B chain amino acid (B30), and a fatty acid side chain (myristic ...Read more

    Structure of insulin detemir. | Download Scientific Diagram


    ResearchGate
    https://www.researchgate.net › figure › Structure-of-ins...
    ResearchGate
    https://www.researchgate.net › figure › Structure-of-ins...
    A long-acting insulin detemir possesses myristic acid attached to the side-chain of LysB29. 18 Conjugation of hexadecanoic diacid to insulin at the same ...Read more

    Insulin Detemir - Diabetes Mellitus: undefined - PDB-101


    RCSB PDB
    https://pdb101.rcsb.org › drugs › insulin › drug › insuli...
    RCSB PDB
    https://pdb101.rcsb.org › drugs › insulin › drug › insuli...
    by C Books — Linear schematic showing amino acid sequence of insulin detemir. Amino acids in the A-chain are shown as blue spheres, while that of the B-chain are shown in ...Read more

    Insulin Detemir Side Chain [Myr-OSu] Manufacturer


    SINOPEG
    https://www.sinopeg.com › insulin-detemir-side-chain-...
    SINOPEG
    https://www.sinopeg.com › insulin-detemir-side-chain-...
    Insulin Detemir Side Chain. Marketed as the brand name product Levemir, insulin detemir has a duration of action of 16-24 hours allowing for once-daily ...Read more

    NDA 21-878 Page 1 LEVEMIR (insulin detemir [rDNA origin ...


    U.S. Food and Drug Administration (.gov)
    https://www.accessdata.fda.gov › label
    U.S. Food and Drug Administration (.gov)
    https://www.accessdata.fda.gov › label
    PDF
    LEVEMIR must only be used if the solution appears clear and colorless with no visible particles. (see DOSAGE AND ADMINISTRATION, Preparation and Handling).Read more
    15 pages

    What is Insulin detemir used for?


    Patsnap Synapse
    https://synapse.patsnap.com › article › what-is-insulin-det...
    Patsnap Synapse
    https://synapse.patsnap.com › article › what-is-insulin-det...
    Jun 14, 2024 — Insulin detemir, commonly known by its trade names Levemir and Levemir FlexTouch, is a long-acting, man-made insulin used in the management ...

    Insulin detemir (subcutaneous route) - Side effects & dosage


    Mayo Clinic
    https://www.mayoclinic.org › drg-20067537
    Mayo Clinic
    https://www.mayoclinic.org › drg-20067537
    Jan 31, 2026 — Insulin detemir is a long-acting insulin that works slowly over 24 hours. You may have to use insulin detemir in combination with another type of insulin or ...Read more

    Levemir Patient Tips: 7 things you should know


    Drugs.com
    https://www.drugs.com › Levemir
    Drugs.com
    https://www.drugs.com › Levemir
    May 7, 2025 — Although it resembles human insulin in most of its structure, the amino acid threonine in position B30 has been omitted, and a C14 fatty acid ...Read more
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