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Semaglutide intermediates are

crucial chemical components used in the synthesis of semaglutide, a medication for type 2 diabetes and weight management . These intermediates include a peptide core, such as the 29-amino acid peptide P29, and a fatty acid "side chain" that is attached to increase the drug's stability and half-life. Specific examples of intermediates are the peptide P29 (GLP-1(9-37)) and the side chain component, octadecanedioic acid or its derivatives.

Key components of semaglutide synthesis

Peptide core : The 29-amino acid peptide, known as P29 or GLP-1(9-37) , forms the main body of semaglutide and is synthesized through recombinant expression.
Side chain : A fatty acid di-acid, such as octadecanedioic acid, is attached to the peptide core through a linker to create the final semaglutide molecule.
Intermediate compounds: Specific chemicals like tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu are also used in the synthesis process, often referred to as the "semaglutide side chain," according to MedchemExpress.com and Cayman Chemical .

Role in drug development

These intermediates are essential for manufacturing semaglutide API (Active Pharmaceutical Ingredient) .

The intermediates are sold by various chemical and pharmaceutical suppliers for research and development purposes, notes ChemicalBook and CPHI Online .

The modifications made possible by these intermediates, such as the addition of the fatty acid chain, improve semaglutide's properties, making it more resistant to degradation by enzymes in the body and allowing for a once-weekly injection schedule.

Semaglutide Intermediate (Recombinant) - CPHI Online
Semaglutide is composed of 31 amino acids and has 94% homology with human GLP-1 (7-37) [Aib replaces Ala at position 8, and Arg re...

CPHI Online
CAS 1118767-15-9 Semaglutide intermediate - BOC Sciences

BOC Sciences
Semaglutide Intermediate P29 (GLP-1(9-37)) - Gene Biocon
Sep 11, 2025 — Semaglutide Intermediate P29 or GLP-1(9-37), is the key intermediate of the synthesis of Semaglutide API. Semaglutide ...

Gene Biocon

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Semaglutide Main Chain (9-37) (CAS 1169630-82-3)

Cayman Chemical

https://www.caymanchem.com › product › semaglutide...

Cayman Chemical

https://www.caymanchem.com › product › semaglutide...

Semaglutide Main Chain (9-37): A peptide starting material in the synthesis of semaglutide. CAS Number: 1169630-82-3. Synonyms: Semaglutide Intermediate 29, ...

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CAS 1169630-82-3 Semaglutide intermediate P29

BOC Sciences

https://www.bocsci.com › product › semaglutide-interm...

BOC Sciences

https://www.bocsci.com › product › semaglutide-interm...

An intermediate of Semaglutide , an agonist of glucagon-like peptide-1 (GLP-1) receptor that is developed to treat type 2 diabetes.

Semaglutide Side Chain,octadecanedioic Acid,Fatty ...

SINOPEG

https://www.sinopeg.com › semaglutide-intermediate_c13

SINOPEG

https://www.sinopeg.com › semaglutide-intermediate_c13

Raw material for Semaglutide side chain . SINOPEG provides various types of fatty acid side chains for diabetes medications.

Semaglutide intermediate P29 - PubChem - NIH

National Institutes of Health (.gov)

https://pubchem.ncbi.nlm.nih.gov › compound › Sema...

National Institutes of Health (.gov)

https://pubchem.ncbi.nlm.nih.gov › compound › Sema...

Semaglutide intermediate P29 | C142H216N38O45 | CID 172878676 - structure, chemical names, physical and chemical properties, classification, patents, ...

Missing: ~~Intermediates~~ ‎| Show results with: Intermediates

Semaglutide Intermediates & Impurities Supplier

Huateng Pharma

https://en.huatengsci.com › products

Huateng Pharma

https://en.huatengsci.com › products

Buy the Intermediates of Semaglutide from the well-known manufacturer Huateng Pharma in China.

Semaglutide 29-Peptide Intermediate: A Key Driver in the ...

Hzymes Biotechnology

https://www.hzymesbiotech.com › articles

Hzymes Biotechnology

https://www.hzymesbiotech.com › articles

As the GLP-1 market continues its rapid expansion, Hzymes is well-positioned to become a leading supplier of semaglutide intermediates . By leveraging innovative ...

Vazyme Is A Trusted Upstream Partner with Large-scale ...

Bio-Connect

https://www.bio-connect.nl › News

Bio-Connect

https://www.bio-connect.nl › News

Sep 19, 2025 — Fuel your semaglutide therapies with Vazyme's P29 peptide intermediate —the reliable, scalable, and high-quality building block behind ...

134979-01-4, CH2COOH-PEG2-NH2.HCl, Semaglutide ...

Biopharma PEG

https://www.biochempeg.com › product

Biopharma PEG

https://www.biochempeg.com › product

Uses： Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis ...

High-Purity Semaglutide Intermediate P29 (GLP-1(9-37))

Gene Biocon

https://www.g-biotec.com › Products › API Pharmaceutical

Gene Biocon

https://www.g-biotec.com › Products › API Pharmaceutical

Semaglutide Intermediate P29 or GLP-1(9-37), is the key intermediate of the synthesis of Semaglutide API . Semaglutide is a 2nd Generation GLP-1RA drug.