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-Formyl-
-hydroxyl poly(ethylene glycol) (OHC-PEG-OH) is a heterobifunctional polymer featuring a reactive aldehyde group at one end and a hydroxyl group at the other. It is primarily used in bioconjugation, surface modification, and forming PEGylated materials, with common molecular weights ranging from 2 kDa to 20 kDa.
Key Characteristics & Applications:
- Structure: Composed of a PEG chain with terminal aldehyde () and hydroxyl () groups, often synthesized via anionic living polymerization.
- Reactivity: The aldehyde group is highly reactive, allowing for conjugation with amines or other nucleophiles, while the hydroxyl group can be further functionalized or used for coupling.
- Uses: Used in the modification of peptides, proteins, and drug delivery systems, aiding in increased solubility and reduced antigenicity.
- Form: Available as a white/off-white solid or viscous liquid, depending on molecular weight, and typically soluble in water, dichloromethane, and DMSO.
- Storage: Recommended storage is typically in a -20°C environment, protected from light and moisture.
Common suppliers of this derivative, such as Sinopeg and CD Bioparticles, offer various molecular weights (e.g., 2KDa, 5KDa, 10KDa, 20KDa) to meet specific research or formulation needs.
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α-Formyl-ω-hydroxyl poly(ethylene glycol) [OHC-PEG-OH]
Amerigo Scientific
https://www.amerigoscientific.com › formyl-hydroxyl-...
Amerigo Scientific
https://www.amerigoscientific.com › formyl-hydroxyl-...
Amerigo Scientific is a specialist distributor in serving life science that provides high quality α-Formyl-ω-hydroxyl poly(ethylene glycol) [OHC-PEG-OH]
α-ForMyl-ω-hydroxyl poly(ethylene glycol)
ChemicalBook
https://www.chemicalbook.com › ChemicalProductProp...
ChemicalBook
https://www.chemicalbook.com › ChemicalProductProp...
α-ForMyl-ω-hydroxyl poly(ethylene glycol) information, including chemical properties, structure, melting point, boiling point, density, formula, ...
Formyl Hydroxyl Poly Ethylene Glycol
SINOPEG
https://www.sinopeg.com ›
SINOPEG
https://www.sinopeg.com ›
α-Formyl-ω-hydroxyl poly(ethylene glycol). Molecular Weight: 2KDa, 5KDa, 10KDa, 20KDa. Package Size: 1g/bottle, 10g/bottle, 100g/bottle.
α-Formyl-ω-hydroxyl poly(ethylene glycol) (MW ... - CD Bioparticles
cd-bioparticles.net
https://www.cd-bioparticles.net › cho-peg-oh
cd-bioparticles.net
https://www.cd-bioparticles.net › cho-peg-oh
Structure, α-Formyl-ω-hydroxyl poly(ethylene glycol) (MW: 2kDa ; PEG Molecular Weight, 5,000 Da ; Functional Group, Aldehyde/Hydroxyl ...
α-Formyl-,ω-Hydroxy-Terminated Poly(ethylene glycol) ...
Polymer Source
https://www.polymersource.ca › productfiledownl...
Polymer Source
https://www.polymersource.ca › productfiledownl...
PDF
α-Formyl-,ω-hydroxy-terminated poly(ethylene glycol) was synthesized by anionic living polymerization of ethylene oxide using diethoxypropanol (acetal) as an.Read more
Web results
A Facile Synthesis of Azido-Terminated Heterobifunctional ...
ACS Publications
https://pubs.acs.org › doi
ACS Publications
https://pubs.acs.org › doi
To prepare α-allyl-ω-hydroxyl PEG (1), the anionic polymerization of EO initiated with potassium allyl alcoholate was carried out in THF solution for 48 h.Read more
Modification of polyethylene glycol
ScienceDirect.com
https://www.sciencedirect.com › article › abs › pii
ScienceDirect.com
https://www.sciencedirect.com › article › abs › pii
by IN Topchieva1988Cited by 17 — A method of synthesis of α-carboxy, ω-oxypolyethylene oxides by oxidation of the semi-acetal bond in cyclic compounds is proposed. Recommended articles ...Read more
Degradable Poly(ethylene glycol) Hydrogels for 2D and 3D ...
Sigma-Aldrich
https://www.sigmaaldrich.com › tissue-engineering › de...
Sigma-Aldrich
https://www.sigmaaldrich.com › tissue-engineering › de...
by AM KaskoCited by 11 — Poly(ethylene glycol) is a readily available, easily modifiable polymer. It has found widespread use in hydrogel fabrication, including as 2D and 3D scaffolds ...Read more
CATALOG & PRICE
Advanced Biochemicals
https://advancedbiochemicals.com › 2017/03 › A...
Advanced Biochemicals
https://advancedbiochemicals.com › 2017/03 › A...
PDF
Alkyne-PEG-OH, 20K. $180/100mg $280/500mg $450/1g $1,800/5g α-Formyl-ω-hydroxyl poly(ethylene glycol). Catalog #. Name and MW. Price. HEP1101. OHC-PEG-OH, 2K.Read more
Heterobifunctional poly(ethylene glycol) derivatives and ...
Google Patents
https://patents.google.com › patent
Google Patents
https://patents.google.com › patent
This invention provides a method for preparing, in high purity and high yield, heterobifunctional derivatives of poly(ethylene glycol) or related polymers.