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4-Arm PEG-CM (4-arm Polyethylene glycol carboxymethyl) is a multi-arm, star-shaped polymer featuring four carboxylic acid groups attached to a pentaerythritol core, primarily used as a crosslinker in biomedical applications, including hydrogel formulation, drug delivery, and pharmaceutical R&D. It offers high reactivity (especially with amines via coupling reagents like EDC/NHS), biocompatibility, and high water solubility.
Key Characteristics and Applications
- Structure: Four arms (each 1/4 of total molecular weight) branching from a central core with terminal -groups.
- Common Molecular Weights: Typically available in 5KDa, 10KDa, 20KDa, and 40KDa.
- Reactivity: Carboxylic acid group (CM) readily reacts with amines, suitable for peptide coupling.
- Applications: Essential for creating PEG hydrogels, modifying drugs, and creating drug-conjugates or biocompatible coatings.
Common Suppliers and Specifications
These products are often available in powder form and are highly purified for scientific research and drug development.
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Web results
4 Arm PEG-CM
Gannet BioChem
https://catalog.gannetbiochem.com › product › 4-arm-p...
Gannet BioChem
https://catalog.gannetbiochem.com › product › 4-arm-p...
4 Arm PEG-Carboxymethyl (4 Arm PEG-CM) is available in molecular weights of 10 kDa and 20 kDa. Packaged in 1 gram and 5 gram bottles.
4-arm PEG-CM
SINOPEG
https://www.sinopeg.com › blog › 4-arm-peg-cm-sinop...
SINOPEG
https://www.sinopeg.com › blog › 4-arm-peg-cm-sinop...
Chapter 1: Basic Information. Name: 4-arm PEG-CM;4-arm Poly(ethylene glycol) carboxylic acid Abbreviation: 4-arm PEG-CM;4-arm PEG-COOH ...Read more
Multiarm PEGs for Hydrogels - JenKem Technology
JenKem Technology USA
https://jenkemusa.com › multi-arm-pegs
JenKem Technology USA
https://jenkemusa.com › multi-arm-pegs
Mar 25, 2026 — JenKem Technology provides high quality activated multi-arm polyethylene glycol derivatives (PEGs) for hydrogels, with high purity and low polydispersity.Read more
4-arm PEG-CM Manufacturer
SINOPEG
https://www.sinopeg.com › 4-arm PEG
SINOPEG
https://www.sinopeg.com › 4-arm PEG
We are professional China 4-arm PEG-CM company,manufacturer 4-arm PEG-CM many years.All PEGs products acquired ISO-9001and ISO-13485 certified.
4-Arm PEG - Creative PEGWorks | PEG Products Leader
Creative PEGWorks
https://creativepegworks.com › Products
Creative PEGWorks
https://creativepegworks.com › Products
Multi-armed PEG reagents functionalized with 4 reactive groups used in PEGylation, hydrogel, crosslinking, coating, nanoparticle, polymer-drug conjugate.Read more
Synthesis of a fluorescent and star-shaped 4-arm PEG with ...
ScienceDirect.com
https://www.sciencedirect.com › article › abs › pii
ScienceDirect.com
https://www.sciencedirect.com › article › abs › pii
by DI Lee2012Cited by 13 — By conjugating PEG arms to DY, we successfully synthesized a star-shaped 4-arm PEG with two carboxylic acid and two amine groups at its four ends. Two different ...Read more
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Web results
4 Arm Peg
SINOPEG
https://www.sinopeg.com › 4-arm-peg_sp
SINOPEG
https://www.sinopeg.com › 4-arm-peg_sp
2-arm Methoxypoly(ethylene glycol)(LYS01). Molecular Weight: 5KDa, 10KDa, 20KDa, 40KDa. Package Size: 1g/bottle, 10g/bottle, 100g/bottle.Read more
More products
- 4arm PEG MaleimideJenKem Technology4arm PEG MaleimideJenKem Technology
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- 4-Arm PEG-OMs, 95%, average M.W. 2,000 | 0J&K ScientificFree delivery4-Arm PEG-OMs, 95%, average M.W. 2,000 | 0J&K ScientificFree delivery
- 4-Arm PEG-SG, MW 5k - Creative PEGWorks | PEG Products LeaderCreative PEGWorks | PEG Products LeaderFree next-day delivery4-Arm PEG-SG, MW 5k - Creative PEGWorks | PEG Products LeaderCreative PEGWorks | PEG Products LeaderFree next-day delivery
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People also ask
Web results
A 4‐Arm PEG‐Thiodepsipeptide Precursor Enables ...
Wiley Online Library
https://onlinelibrary.wiley.com › full › mame.202300146
Wiley Online Library
https://onlinelibrary.wiley.com › full › mame.202300146
by MY Folikumah2023 — It is shown that hydrolytic enzymes can be used to initiate the formation of covalent hydrogel networks, realizing a cleavage-leading-to-gelation strategy.Read more
4-arm PEGs - Nanosoft Polymers
nanosoftpolymers.com
https://www.nanosoftpolymers.com › functional-pegs
nanosoftpolymers.com
https://www.nanosoftpolymers.com › functional-pegs
4-Arm PEGs is a family of multi-arm polyethylene glycol with hydroxyl groups at each terminal of the four arms. Pentaerythritol core is used in 4arm PEG raw ...Read more
How do you reduce the gelling time of 4 arm peg ...
ResearchGate
https://www.researchgate.net › post › How_do_you_red...
ResearchGate
https://www.researchgate.net › post › How_do_you_red...
Mar 17, 2015 — I'm trying to slow down the gelling of 4 arm peg maleimide crosslinked with peg dithiol. I'm using (at the moment) 20 kDa 4 arm peg maleimide + ...Read more