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Methyl olivetolate (
, CAS 58016-28-7) is a crucial organosynthetic intermediate and biological precursor to
-tetrahydrocannabinolic acid (THCA), the precursor to THC. It features a unique molecular structure of methyl 2,4-dihydroxy-6-pentylbenzoate, commonly used in cannabinoid biosynthesis research due to its ability to be prenylated to form cannabigerolic acid (CBGA).
Key Aspects of Methyl Olivetolate:
- Molecular Architecture: It is a phenolic ester, specifically the methyl ester of olivetolic acid, characterized by a 2,4-dihydroxy-6-pentylbenzoate structure.
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Olivetolate - an overview | ScienceDirect Topics
ScienceDirect.com
https://www.sciencedirect.com › topics › chemistry › oliv...
ScienceDirect.com
https://www.sciencedirect.com › topics › chemistry › oliv...
Through two polyketide pathways, fatty acids and coenzymes synthesize olivetolic acid and divarinolic acid. These acids react with the substrate geranyl ...Read more
Methyl Olivetolate with Unique Molecular Architecture - Qixi Chemicals
qixiolivetol.com
https://www.qixiolivetol.com › tag › methyl-olivetolate-...
qixiolivetol.com
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This compound features a unique molecular architecture that combines a resorcinol-derived aromatic core with a lipophilic pentyl chain and a versatile ...
CAS No : 58016-28-7 | Product Name : Methyl Olivetolate
Pharmaffiliates
https://www.pharmaffiliates.com › 58016-28-7-methyl-...
Pharmaffiliates
https://www.pharmaffiliates.com › 58016-28-7-methyl-...
Methyl Olivetolate is an intermediate in synthesizing Δ9-Tetrahydrocannabinolic Acid (Acid A & B). It is one of the substances screened for in meconium drug ...Read more
Characterization of olivetol synthase, a ... - FEBS Press
FEBS Press
https://febs.onlinelibrary.wiley.com › doi › j.febslet.200...
FEBS Press
https://febs.onlinelibrary.wiley.com › doi › j.febslet.200...
by F Taura2009Cited by 231 — Crystal structural analysis and site directed mutational studies of OLS are now in progress to probe the structural basis for the unique ...Read more
CAS 58016-28-7 (Methyl Olivetolate)
BOC Sciences
https://www.bocsci.com › ... › Intermediates
BOC Sciences
https://www.bocsci.com › ... › Intermediates
Methyl Olivetolate is an intermediate in the synthesis of Δ9-Tetrahydrocannabinolic Acid, the biosynthetic precursor of delta-9-tetrahydrocannabinol (THC) ...
$328.00
Synthesis of Cannabigerol and Cannabigerol Derivatives
MDPI
https://www.mdpi.com › ...
MDPI
https://www.mdpi.com › ...
by JF Ortuño2025Cited by 1 — Over 100 distinct cannabinoids have been identified, each with a unique chemical structure and pharmacological profile. ... methyl olivetolate and orthogonally ...Read more
Designing microorganisms for heterologous biosynthesis of ...
Oxford Academic
https://academic.oup.com › femsyr › article › fox037
Oxford Academic
https://academic.oup.com › femsyr › article › fox037
by  Carvalho2017Cited by 96 — In this review, the authors explore the use of synthetic biology as an alternative approach for the synthesis of pharmaceutical cannabinoids in a heterolog.
WO2019190945A1 - Biosynthesis of olivetolic acid
Google Patents
https://patents.google.com › patent
Google Patents
https://patents.google.com › patent
This invention allows the efficient microbial production of olivetolic acid, divarinolic acid, orsellinic acid and other aromatic polyketides.Read more
Methyl olivetolate - Inxight Drugs
Inxight Drugs
https://drugs.ncats.io › substance
Inxight Drugs
https://drugs.ncats.io › substance
Stereochemistry, ACHIRAL ; Molecular Formula, C13H18O4 ; Molecular Weight, 238.2796 ; Optical Activity, NONE ; Defined Stereocenters, 0 / 0.Read more