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    AI Overview
    Fumaric acid (
    C4H4O4cap C sub 4 cap H sub 4 cap O sub 4
    𝐶4𝐻4𝑂4
    ) is a white, crystalline organic acid used in pharmaceuticals as an excipient, pH adjuster, and acidifier to enhance solubility and drug stability, particularly in oral and effervescent formulations. It is known for high acid strength, low moisture absorption, and as a precursor for therapeutic esters treating multiple sclerosis and psoriasis. 
    Pharmaceutical Applications & Benefits 
    • pH Regulation and Stability: Fumaric acid is used to maintain stable pH levels in drug formulations, enhancing the solubility of active pharmaceutical ingredients (APIs). 
    • Controlled Release: It serves as an agent to help manage the dissolution rates of medications. 
    • Effervescent Formulations: Due to its acidic nature, it is used in effervescent tablets, providing efficient and consistent effervescence. 
    • Therapeutic Derivatives: Fumaric acid esters, such as dimethyl fumarate, are used in treating relapsing-remitting multiple sclerosis (MS) and psoriasis. 
    • Antimicrobial Agent: Studies indicate it has potent inhibitory effects against various microorganisms (e.g., E. coli, S. aureus). 
    • Excipient Function: It is used in the manufacturing of compounds like ferrous fumarate (iron supplement). 
    Key Properties 
    • High Acidity: Provides strong acidic functionality (higher acidity per unit weight than many other organic acids).
    • Low Hygroscopicity: It does not absorb moisture easily, which ensures the stability of pharmaceutical formulations.
    • Safety Profile: It is recognized as a safe compound, with low toxicity (e.g.,
      LD50cap L cap D sub 50
      𝐿𝐷50
       in rats is approximately 10,000 mg/kg).       
    Fumaric acid is also used in the food industry as an acidulant (E297) and in animal feed as an acidifier to promote growth. 
    • Fumaric acid - PENPET Petrochemical Trading
      Fumaric acid is an unsaturated dicarboxylic acid, also known in the scientific literature as trans-butenedioic acid and trans-ethy...
      PENPET Petrochemical Trading
    • Medicine Science | A preliminary study of fumaric acid, called allomaleic acid, as a pharmaceutical antimicrobial compound
      A preliminary study of fumaric acid, also known as allomaleic acid, as a pharmaceutical antimicrobial compound found that it has a...
      Medicine Science
    • Fumaric acid Dealer and Distributor - Multichem Specialities
      Industrial Uses * Food & Healthcare Ingredients. Acidulant: Fumaric acid is commonly used to add a sour or tart flavor to food and...
      Multichem Specialities
    • Fumaric Acid - Catalynt Solutions
      Catalynt proudly offers Fumaric Acid (CAS No. 110-17-8), a high-quality, multipurpose ingredient widely used across food, pharmace...
      Catalynt
    • Fumaric Acid (E297) Supplier – Food Grade Acidulant & Additive
      Description. Fumaric Acid is in the shape of colorless crystal, existing in many kinds of mushrooms and fresh beef. Fumaric Acid c...
      www.foodchem.com
    • Fumaric Acid: An Ultimate Guide - Niran Bio
      Sep 5, 2025 — Safety Assessments. Acute Toxicity: LD₅₀ in rats ~10,000 mg/kg (low toxicity). Irritation: Generally non-irritant in low concentra...
      Niran Bio
    • Fumaric Acid | USP, FCC Grade – Reliable U.S. Supplier
      Fumaric acid is naturally found in various fruits and vegetables, and it is also synthesized industrially for various applications...
      Allan Chemical Corporation
    • Fumaric Acid: Uses, Properties, Safety, and Sources - Welcome to FIC
      Oct 11, 2025 — Common Uses of Fumaric Acid * Food Industry (Most Widespread Use)​ The U.S. Food and Drug Administration (FDA) classifies fumaric ...
      www.ficchem.com
    • Fumaric Acid
      Jul 28, 2022 — fumericic acid is an organic white crystalline powder and one of two unsaturated dicaroxilic acids it is used primarily in the foo...
      1m
      YouTube·The Chemical Company
    • Fumaric acid - PENPET Petrochemical Trading
      Fumaric acid is an unsaturated dicarboxylic acid, also known in the scientific literature as trans-butenedioic acid and trans-ethy...
      PENPET Petrochemical Trading
    • Medicine Science | A preliminary study of fumaric acid, called allomaleic acid, as a pharmaceutical antimicrobial compound
      A preliminary study of fumaric acid, also known as allomaleic acid, as a pharmaceutical antimicrobial compound found that it has a...
      Medicine Science
    • Fumaric acid Dealer and Distributor - Multichem Specialities
      Industrial Uses * Food & Healthcare Ingredients. Acidulant: Fumaric acid is commonly used to add a sour or tart flavor to food and...
      Multichem Specialities
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    Fumaric acid


    PENPET Petrochemical Trading
    https://www.penpet.com › products › synthetic-resins › f...
    PENPET Petrochemical Trading
    https://www.penpet.com › products › synthetic-resins › f...
    As a food additive E 297, fumaric acid is an important acidifier. The pharmaceutical industry mainly uses the compound as a carrier medium to administer ...Read more
    Pharmaceutical Acidifier Fumaric Acid from www.penpet.com
    Popular products
    • Fumaric Acid Extra Pure - Amaris Chemical Solutions.
      Fumaric Acid Extra Pure - Amaris Chemical Solutions
      $18.54
      Amaris Chemical Solutions
      Fumaric Acid Extra Pure - Amaris Chemical Solutions
      $18.54
      Amaris Chemical Solutions
    • Sigma-Aldrich Fumaric Acid CAS 110-17-8.
      Sigma-Aldrich Fumaric Acid CAS 110-17-8
      $23.30
      Sigma-Aldrich
      Sigma-Aldrich Fumaric Acid CAS 110-17-8
      $23.30
      Sigma-Aldrich
    • Fumaric Acid.
      Fumaric Acid
      $41.99
      Lodi Wine Labs
      Fumaric Acid
      $41.99
      Lodi Wine Labs
    • Fumaric acid.
      Fumaric acid
      $29.00
      TargetMol Chemicals
      Fumaric acid
      $29.00
      TargetMol Chemicals
    • Sigma-Aldrich Fumaric Acid.
      Sigma-Aldrich Fumaric Acid
      $48.80
      Sigma-Aldrich       & more
      Sigma-Aldrich Fumaric Acid
      $48.80
      Sigma-Aldrich       & more
    • SuperSmart Fumaric Acid 500mg.
      SuperSmart Fumaric Acid 500mg
      $18.00
      Nordstrom       & more
      Free delivery
      4.7(24)
      SuperSmart Fumaric Acid 500mg
      $18.00
      Nordstrom       & more
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      4.7(24)
    • NSI Lab Solutions PH1968 Fumaric Acid Pharmaceutical Reference Material, 1 g | Cole-Parmer.
      NSI Lab Solutions PH1968 Fumaric Acid Pharmaceutical Reference Material, 1 g | Cole-Parmer
      $79.00
      Cole-Parmer
      NSI Lab Solutions PH1968 Fumaric Acid Pharmaceutical Reference Material, 1 g | Cole-Parmer
      $79.00
      Cole-Parmer
    • Fumaric Acid, FCC.
      Nearby, 7 mi
      Fumaric Acid, FCC
      $276.15
      labproinc.com
      Nearby, 7 mi
      Fumaric Acid, FCC
      $276.15
      labproinc.com

    Web results

    Fumaric Acid in Industrial Applications From Resins to ...


    Coherent Market Insights
    https://www.coherentmarketinsights.com › ... › Category
    Coherent Market Insights
    https://www.coherentmarketinsights.com › ... › Category
    Feb 7, 2025 — Fumaric acid is essential in multiple industries enhancing food safety pharmaceutical efficacy and resin durability.

    Pharmaceutical Acidifier Fumaric Acid


    GNF Chemical
    https://www.gnfchem.com › pharmaceutical-acidifier-fu...
    GNF Chemical
    https://www.gnfchem.com › pharmaceutical-acidifier-fu...
    Professional Pharmaceutical Acidifier Fumaric Acid suppliers and manufacturers,GNF provides high quality Pharmaceutical Acidifier Fumaric Acid for various ...

    The roles of acidifiers in solid dispersions and physical ...


    ScienceDirect.com
    https://www.sciencedirect.com › article › abs › pii
    ScienceDirect.com
    https://www.sciencedirect.com › article › abs › pii
    by TTD Tran · 2010 · Cited by 115 — The dissolution rate of isradipine from solid dispersion was ranked by acidifiers in a decreasing order: fumaric acid, citric acid, glycolic acid and malic acid ...Read more

    Fumaric Acid - Metabolon


    metabolon.com
    https://www.metabolon.com › Metabolites
    metabolon.com
    https://www.metabolon.com › Metabolites
    Fumaric acid is used as a food additive and food acidulant, acting as a potent flavoring agent for gelatin desserts, baking powders, and fruit juices. The ...Read more
    Missing: Pharmaceutical ‎Acidifier

    Fumaric Acid


    Bartek Ingredients
    https://www.bartek.ca › Products
    Bartek Ingredients
    https://www.bartek.ca › Products
    Fumaric acid serves a variety of functional purposes, including enhancing taste, managing pH, reducing hygroscopicity, improving shelf stability, and more.
    Missing: Acidifier ‎| Show results with: Acidifier

    Fumaric Acid


    Catalynt
    https://teamcatalynt.com › ... › Water Treatment
    Catalynt
    https://teamcatalynt.com › ... › Water Treatment
    High Acid Strength: Provides effective acidification in food, pharmaceutical, and industrial formulations. Low Hygroscopicity: Ensures long-term stability ...Read more
    Missing: Acidifier ‎| Show results with: Acidifier
    People also ask
    What is fumaric acid used for in pharmaceuticals?
    Fumaric acid is increasingly used in the production of a variety of drugs. For instance, medications made for treating psoriasis and multiple sclerosis often contain fumaric acid. It is essential for producing antimalarials, antihistamines, and analgesics. Trans-butenedioic acid possesses antimicrobial properties.Feb 7, 2025

    Fumaric Acid in Industrial Applications From Resins to ...


    Coherent Market Insights
    https://www.coherentmarketinsights.com › ... › Category
    Coherent Market Insights
    https://www.coherentmarketinsights.com › ... › Category
    What is fumaric acid and is it bad for you?
    Fumaric Acid is a colorless to white, odorless, crystalline powder. It is used as a food additive, as an antioxidant in resins, and to make dyes. * Fumaric Acid is on the Hazardous Substance List because it is cited by DOT and EPA.

    FUMARIC ACID CAS Number - NJ.gov


    HAZARD SUMMARY IDENTIFICATION REASON FOR ...
    https://nj.gov › health › eoh › rtkweb › documents
    HAZARD SUMMARY IDENTIFICATION REASON FOR ...
    https://nj.gov › health › eoh › rtkweb › documents
    Is fumaric acid allowed in Europe?
    Fumaric acid has been used as a food acidulant since 1946. It is approved for use as a food additive in the EU, USA and Australia and New Zealand.

    Fumaric acid - Wikipedia


    Wikipedia
    https://en.wikipedia.org › wiki › Fumaric_acid
    Wikipedia
    https://en.wikipedia.org › wiki › Fumaric_acid
    What products have fumaric acid in them?
    Fumaric acid is included in many dairy-based products such as chocolate milk, cocoa, eggnog, condensed milk, milk and cream powders or substitutes and yogurts. Fumaric acid is added to cheese products, including processed cheese.

    Fumaric Acid - ATPGroup


    ATPGroup
    https://atpgroup.com › product › fumaric-acid-3
    ATPGroup
    https://atpgroup.com › product › fumaric-acid-3

    Web results

    Fumaric Acid: An Ultimate Guide


    Niran Bio
    https://www.niranbio.com › News
    Niran Bio
    https://www.niranbio.com › News
    Sep 5, 2025 — Fumaric acid is a stable dicarboxylic acid widely used as an acidulant, preservative, and industrial intermediate across food, ...
    Missing: Acidifier ‎| Show results with: Acidifier
    More products
    • Fumaric acid, 99% 500g.
      Fumaric acid, 99% 500g
      $41.80
      Chemsavers Inc
      Fumaric acid, 99% 500g
      $41.80
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    • Fumaric Acid 50 g.
      Fumaric Acid 50 g
      $0.57
      Mylo Opt Global
      Fumaric Acid 50 g
      $0.57
      Mylo Opt Global
    • Supelco Fumaric Acid Certified Reference Material.
      Supelco Fumaric Acid Certified Reference Material
      $140.00
      Sigma-Aldrich
      Supelco Fumaric Acid Certified Reference Material
      $140.00
      Sigma-Aldrich
    • Fumaric Acid, 99%,100 G - 16071.
      Nearby, 7 mi
      Fumaric Acid, 99%,100 G - 16071
      $34.14
      labproinc.com
      Nearby, 7 mi
      Fumaric Acid, 99%,100 G - 16071
      $34.14
      labproinc.com
    • Fumaric Acid FCC, Fine Granular | 50 lb Bag.
      Fumaric Acid FCC, Fine Granular | 50 lb Bag
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      Ingredi
      Fumaric Acid FCC, Fine Granular | 50 lb Bag
      $222.08
      Ingredi
    • Fumaric Acid, 500 grams.
      Fumaric Acid, 500 grams
      $49.99
      CP Lab Safety
      Free delivery on $50+
      Fumaric Acid, 500 grams
      $49.99
      CP Lab Safety
      Free delivery on $50+
    • Fumaric Acid 10 lbs.
      Fumaric Acid 10 lbs
      $55.00
      California Ingredients
      Fumaric Acid 10 lbs
      $55.00
      California Ingredients
    • Fumaric Acid Regular, FCC.
      Fumaric Acid Regular, FCC
      $247.50
      Bartek Ingredients
      Fumaric Acid Regular, FCC
      $247.50
      Bartek Ingredients

    Web results

    A preliminary study of fumaric acid, called allomaleic ...


    Medicine Science
    https://www.medicinescience.org › article
    Medicine Science
    https://www.medicinescience.org › article
    Fumaric acid, or allomaleic acid, is a natural bioactive compound primarily derived from plant-based products. Fumaric acid has potential analgesic, anti- ...Read more

    Fumaric Acid - Shanghai Valley Lily BioTech Co. Ltd.


    vl-additives.com
    https://vl-additives.com › product › fumaric-acid-feed-fo...
    vl-additives.com
    https://vl-additives.com › product › fumaric-acid-feed-fo...
    Fumaric Acid is particularly valued for its ability to acidify feed, improve nutrient absorption, and enhance gut health in animals. In food products, it acts ...Read more
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