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    AI Overview
    α-Glu(side chain)-Semaglutide - Daicel Pharma Standards
    The semaglutide side chain (typically CAS# 1118767-16-0) is a crucial fatty diacid component,
    𝐶43
    𝐻79
    𝑁3𝑂13
    , used to modify the GLP-1 peptide backbone, enabling the drug's long-acting, weekly administration. It structure features a stearic acid fatty chain, a
    γgamma
    𝛾
    -glutamic acid spacer, and two AEEA (2-[2-(amino)ethoxy]ethoxy]acetic acid) units, which increase albumin binding and resist degradation. 
    Key Components of the Semaglutide Side Chain: 
    • Stearic Acid: A C18 fatty acid chain that promotes albumin binding, prolonging the drug's half-life.
    • γgamma
      𝜸
      -Glutamic Acid:       A spacer that links the stearic acid to the peptide backbone.
    • AEEA Units: Two (2-[2-(amino)ethoxy]ethoxy]acetic acid) groups that act as a hydrophilic linker, enhancing solubility and improving pharmacokinetic properties.
    • Chemical Structure/Intermediate: The commonly used intermediate for synthesizing the side chain is
      tBuOt cap B u cap O
      𝑡𝐵𝑢𝑂
      -Ste-Glu(
      AEEAcap A cap E cap E cap A
      𝐴𝐸𝐸𝐴
      -
      AEEAcap A cap E cap E cap A
      𝐴𝐸𝐸𝐴
      -
      OSucap O cap S u
      𝑂𝑆𝑢
      )-
      OtBucap O t cap B u
      𝑂𝑡𝐵𝑢
      .       
    Function in Semaglutide: 
    • Extended Half-Life: The side chain enables semaglutide to bind to albumin, reducing renal clearance and allowing for once-weekly dosing.
    • Stability: It protects the peptide from degradation by dipeptidyl peptidase-4 (DPP-4).
    • Synthesis: It is attached to the Lysine residue at position 26 of the GLP-1 analog backbone during the synthesis process. 
    Key Identifiers: 
    • CAS Number: 1118767-16-0 (side chain derivative), 1169630-40-3 (activated side chain)
    • Molecular Weight: 846.11
    • Molecular Formula:
      𝐶43
      𝐻79
      𝑁3𝑂13
       
    Disclaimer: This information is for research use only (RUO) and relates to chemical intermediates, not the final drug product. 
    • Semaglutide Side Chain | synthetic intermediate | CAS#1118767-16-0 | MedKoo
      The molecular weight of semaglutide side chain is 846.11. The chemical formula for semaglutide side chain is C43H79N3O13. The exac...
      MedKoo Biosciences
    • Fmoc-Lys(tBuO-Ste-Glu(AEEA-AEEA)-OtBu)-OH (Fatty Acid Side Chain) - JenKem Technology USA
      This information does not constitute medical advice or diagnosis. Fatty acid side chains can improve patient compliance by prolong...
      JenKem Technology USA
    • Ste-Glu-AEEA-AEEA-OSU (Fatty Acid Side Chain)
      Description. JenKem Technology provides fatty acid side chain Ste-Glu-AEEA-AEEA-OSU (CAS# 1169630-40-3) with high purity (≥90%) fo...
      JenKem Technology USA
    • Semaglutide Side Chain | TBuO-Ste-Glu(AEEA-AEEA-OSu)-OtBu
      Jul 5, 2024 — Widely used in solid-phase peptide synthesis and subsequent functional group modifications, the Semaglutide Side Chain helps contr...
      SINOPEG
    • Semaglutide Side Chain | CAS NO.:1118767-16-0 - GlpBio
      Description of Semaglutide Side Chain Semaglutide side chain is a synthetic intermediate. It has been used as an intermediate in t...
      GlpBio
    • Overcoming the “Choke Points” in Semaglutide Side Chain
      May 21, 2025 — Overcoming the ​“Choke Points” in Semaglutide Side Chain Synthesis with Core Technologies to Enable Efficient GLP-1 Drug Manufactu...
      Watson International Limited
    • Semaglutide Side Chain | synthetic intermediate | CAS#1118767-16-0 | MedKoo
      The molecular weight of semaglutide side chain is 846.11. The chemical formula for semaglutide side chain is C43H79N3O13. The exac...
      MedKoo Biosciences
    • Fmoc-Lys(tBuO-Ste-Glu(AEEA-AEEA)-OtBu)-OH (Fatty Acid Side Chain) - JenKem Technology USA
      This information does not constitute medical advice or diagnosis. Fatty acid side chains can improve patient compliance by prolong...
      JenKem Technology USA
    • Ste-Glu-AEEA-AEEA-OSU (Fatty Acid Side Chain)
      Description. JenKem Technology provides fatty acid side chain Ste-Glu-AEEA-AEEA-OSU (CAS# 1169630-40-3) with high purity (≥90%) fo...
      JenKem Technology USA
    Show all
    This is for informational purposes only. For medical advice or diagnosis, consult a professional. AI responses may include mistakes. Learn more
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    Semaglutide Side Chain (CAS Number: 1118767-16-0)


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    Semaglutide side chain is a synthetic intermediate. 1 It has been used as an intermediate in the synthesis of the glucagon-like peptide 1 receptor (GLP-1R) ...Read more
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    Semaglutide Side Chain | synthetic intermediate


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    Semaglutide side chain is a synthetic intermediate. Semaglutide is a long-acting GLP-1 receptor agonist that effectively lowers blood glucose, reduces HbA1c ...
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    [alpha-Glu(side chain)]-Semaglutide (10 mg) ...


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    THIS ITEM HAS BEEN IDENTIFIED AS A POTENTIALLY DANGEROUS GOOD. SPECIAL SHIPPING METHODS AND CHARGES MAY APPLY. THIS ITEM REQUIRES SPECIAL COLD CHAIN ...Read more

    tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu (Semaglutide side ...


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    tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu is an intermediate in the synthesis of the glucagon-like peptide 1 receptor (GLP-1R) agonist Semaglutide (HY-114118).Read more
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    What is the name of the side chain of semaglutide?
    Semaglutide Side Chain-tBuO-Ste-Glu(AEEA-AEEA-OH)OtBu is used as a reference standard in analytical research. It ensures consistency of formulations.

    Semaglutide Side Chain-tBuO-Ste-Glu(AEEA-AEEA ...


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    What is the controversy with semaglutide?
    FDA issued a warning in July 2023 after receiving several reports of adverse effects from people who used compounded semaglutide. In some cases, compounders used the salt forms of semaglutide, which have different active ingredients than the approved drug.

    Concerns with Semaglutide and Other GLP-1 Receptor Agonists


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    Introduction To The Side Chain Of Semaglutide


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    Jan 13, 2026 — In summary, this ingeniously designed side chain extends the half-life of the drug from just minutes (for native human GLP-1) to approximately ...Read more

    Semaglutide


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    The most common side effects include nausea, vomiting, diarrhea, abdominal pain, and constipation.Read more

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    It is a further objective of the present invention to provide an improved and commercially viable process for the synthesis of Semaglutide side chain. SUMMARY ...Read more

    Improving Solid-State Properties of the Side-Chain Peptide ...


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    Lastly, the efficiency of the coupling of the Mg-complexed lipidated side-chain building blocks was confirmed for the synthesis of tirzepatide and semaglutide ...Read more

    Fmoc-Lys(tBuO-Ste-Glu(AEEA-AEEA)-OtBu)-OH (Fatty ...


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    Fatty acid side chains are known to improve patient compliance by to prolonging the half-life of Glucagon-like peptide-1 (GLP-1) receptor agonists used in the ...Read more
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