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    AI Overview
    mPEG-PA can refer to two different polymer conjugates:
    Methoxy Poly(ethylene glycol)-Propionic Acid , a PEGylation reagent used in drug delivery and biopharmaceutical research, or Methoxy Poly(ethylene glycol)-Palmitic Acid , a polymeric amphiphile also used in drug delivery. The "PA" in the acronym can represent either propionic acid or palmitic acid, depending on the specific chemical compound and its intended application.
    1. Methoxy Poly(ethylene glycol)-Propionic Acid (mPEG-PA)
    • What it is: A linear, monofunctional PEG reagent with a reactive carboxylic acid group at one end. It is created by reacting methoxy poly(ethylene glycol) (mPEG) with propionic acid.
    • Primary use: A PEGylation agent . The carboxyl group can be activated to react with amine groups on proteins, which is used to:
      • Improve drug solubility and stability.
      • Increase the half-life of proteins and enzymes in the body.
      • Reduce immunogenicity .
    • Applications: Medical research, drug delivery, nanotechnology, and modifying functional coatings.
    2. Methoxy Poly(ethylene glycol)-Palmitic Acid (mPEG-PA)
    • What it is: A polymeric amphiphile with a hydrophilic mPEG chain and a hydrophobic palmitic acid (PA) tail.
    • Primary use: Used to form self-assembled structures like micelles in aqueous solutions.
    • Applications: Drug delivery systems where hydrophobic drugs can be encapsulated in the core of the micelle. Research has explored its use in delivering cancer chemopreventive agents like curcumin.
    • MPEG-propionic acid - NSP-Functional Polymers & Copolymers
      Product Description. Methoxy poly(ethylene glycol)-propionic acid (MPEG-propionic acid, MPEG-PA) is one type of linear monofunctio...
      www.nanosoftpolymers.com
    • palmitate nanocarrier for curcumin delivery to cancer cells
      Nov 14, 2008 — Abstract. A novel polymeric amphiphile, mPEG–PA, was synthesized with methoxy poly(ethylene glycol) (mPEG) as the hydr...
      ScienceDirect.com
    • MPEG-PA | SINOPEG Peg Derivative Functional Group
      Dec 19, 2024 — mPEG-PA, also known as Methoxypoly(ethylene glycol) Propionic Acid or methoxy-polyethylene glycol propionic acid, is a...
      www.sinopeg.com
    • Methoxypoly(ethylene glycol) propionic acid [mPEG-PA]
      mPEG-PA. Product Name: Methoxypoly(ethylene glycol)propionic acid. Abbrevition: mPEG-PA. Molecular Weight: 10KDa, 20KDa, 40KDa. Pa...
      SINOPEG
    • mPEG Propionic Acid (mPEG-CH2CH2COOH)
      Synonyms: mPEG-PA. mPEG-Propionic acid. Purity: Recommended Storage Condition: Store at -5°C,keep in dry and avoid sunlight. Uses:...
      Biopharma PEG
    • Good News! mPEG-pALD (20K) Successfully Completed The FDA ...
      Jan 13, 2025 — Product Information. ... Appearance: White or off-white powder. Properties: Reactivity: mPEG-pALD is a monofunctional ...
      Biopharma PEG
    • MPEG-propionic acid - NSP-Functional Polymers & Copolymers
      Product Description. Methoxy poly(ethylene glycol)-propionic acid (MPEG-propionic acid, MPEG-PA) is one type of linear monofunctio...
      www.nanosoftpolymers.com
    • palmitate nanocarrier for curcumin delivery to cancer cells
      Nov 14, 2008 — Abstract. A novel polymeric amphiphile, mPEG–PA, was synthesized with methoxy poly(ethylene glycol) (mPEG) as the hydr...
      ScienceDirect.com
    • MPEG-PA | SINOPEG Peg Derivative Functional Group
      Dec 19, 2024 — mPEG-PA, also known as Methoxypoly(ethylene glycol) Propionic Acid or methoxy-polyethylene glycol propionic acid, is a...
      www.sinopeg.com
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    Thermo-Sensitive mPEG-PA-PLL Hydrogel for Drug ...


    National Institutes of Health (.gov)
    https://pubmed.ncbi.nlm.nih.gov › ...
    National Institutes of Health (.gov)
    https://pubmed.ncbi.nlm.nih.gov › ...
    by YE Cheng · 2022 · Cited by 11 — Methoxy poly(ethylene glycol)-poly(l-alanine) ( mPEG - PA ) is a thermo-sensitive hydrogel exhibiting a sol-to-gel phase transition property. This ...

    MPEG-PA | SINOPEG Peg Derivative Functional Group


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    SINOPEG
    https://www.sinopeg.com › blog › mpeg-pa-sinopeg-pe...
    Dec 20, 2024 — Mpeg - pa is synthesized by a chemical reaction of polyethylene glycol monomethyl ether (mPEG) and propionic acid (PA). Among them, the mPEG part ...

    mPEG-PA


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    palmitate nanocarrier for curcumin delivery to cancer cells


    ScienceDirect.com
    https://www.sciencedirect.com › article › abs › pii
    ScienceDirect.com
    https://www.sciencedirect.com › article › abs › pii
    by A Sahu · 2008 · Cited by 305 — The mPEG – PA conjugate forms self-assembled micelle nanoparticles with hydrophobic anticancer drug curcumin in the core. We also demonstrate enzyme-triggered ...

    MPEG-propionic acid - NSP-Functional Polymers & Copolymers


    nanosoftpolymers.com
    https://www.nanosoftpolymers.com › product › mpeg-p...
    nanosoftpolymers.com
    https://www.nanosoftpolymers.com › product › mpeg-p...
    Methoxypoly(ethylene glycol)propionic acid is a pegylation agent used to conjugate proteins to reduce immunogenicity and prolong serum half-life of proteins ...
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    mPEG Propionic Acid (mPEG-CH2CH2COOH)


    Biopharma PEG
    https://www.biochempeg.com › product
    Biopharma PEG
    https://www.biochempeg.com › product
    Methoxy PEG Propionic Acid ( mPEG -CH2CH2COOH) is an Amine PEGylation reagent reactive towards the amino group of lysine(s) at pH 7-8.
    $55 delivery

    Methoxypoly(ethylene glycol) propionic acid [mPEG-PA]


    SINOPEG
    https://www.sinopeg.com › methoxypoly-ethylene-glyc...
    SINOPEG
    https://www.sinopeg.com › methoxypoly-ethylene-glyc...
    Methoxypoly(ethylene glycol)propionic acid ( mPEG - PA )is formed by a degradable linker connecting PEG polymer chain anda carboxyl group on the other, which is ...

    Poly(ethylene glycol) Monomethyl Ether (mPEG)


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    Explore high-purity mPEG polymers from Polysciences, ideal for drug delivery, surface modification, and biomedical research ... 400 Valley Road, Warrington, PA ...

    (PDF) Thermo-Sensitive mPEG-PA-PLL Hydrogel for Drug ...


    ResearchGate
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    ResearchGate
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    Oct 14, 2025 — Methoxy poly(ethylene glycol)-poly(l-alanine) ( mPEG - PA ) is a thermo-sensitive hydrogel exhibiting a sol-to-gel phase transition property. This ...

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    mPEG reagents functionalized with one reactive group used in PEGylation, surface and nanoparticle PEG anti-fouling coating, polymer drug conjugation.

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