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Methoxy-PEG-SPA (Methoxy PEG Succinimidyl Propionate) is a high-purity, amine-reactive PEG linker used for PEGylation, primarily to conjugate with primary amines on proteins, peptides, and surfaces. It offers superior stability, high reactivity, and a longer hydrolysis half-life compared to M-PEG-SCM, making it ideal for drug delivery and enhancing drug stability.
Key Features and Applications of mPEG-SPA:
- Reactivity: Reacts with lysine residues, arginine, and histidine on protein surfaces under alkaline conditions.
- Applications: Used extensively in medical research, pharmaceutical manufacturing for PEGylated drugs (e.g., PEG-uricase), and surface modification (e.g., cell camouflage).
- Stability: Provides a longer hydrolysis half-life compared to first-generation products like mPEG-SCM.
- Molecular Weights: Available in various molecular weights (e.g., 5 kDa, 10 kDa, 20 kDa) to suit different requirements.
Suppliers and Services:
- JenKem Technology: Provides high-purity GMP-grade mPEG-SPA and other activated PEGs.
- AxisPharm: Offers mPEG-SPA products, including low molecular weight versions (e.g., MW 550).
- SinoPEG: Specializes in producing mPEG-SPA (CAS numbers include 622405-78-1, 874208-94-3, etc.).
- BiochemPEG: Supplies various molecular weights of mPEG-SPA.
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Methoxy PEG Succinimidyl Propionate
JenKem Technology USA
https://jenkemusa.com › product › methoxy-peg-succin...
JenKem Technology USA
https://jenkemusa.com › product › methoxy-peg-succin...
Methoxy PEG Succinimidyl Propionate has a longer hydrolysis half-life compared with M-PEG-SCM. JenKem Technology offers Methoxy PEG SPA with MW 5000 Da (M-SPA- ...Read more
$120.00In stock
Methoxypolyethylene glycol 5000 propionic acid ≥80%
Sigma-Aldrich
https://www.sigmaaldrich.com › product › sigma
Sigma-Aldrich
https://www.sigmaaldrich.com › product › sigma
Methoxypolyethylene glycol 5,000 propionic acid (M-SPA-PEG 5000) is a pegylation agent used to conjugate proteins to reduce immunogenicity and prolong serum ...Read more
2–3 day delivery
MPEG-SPA Manufacturer
SINOPEG
https://www.sinopeg.com › mpeg-spa_p67
SINOPEG
https://www.sinopeg.com › mpeg-spa_p67
We are professional China Methoxy-PEG-SPA company,manufacturer mPEG-SPA many years.All PEGs products acquired ISO-9001and ISO-13485 certified.
Study on the Interaction Mechanism of Methoxy Polyethylene ...
PubMed Central (PMC) (.gov)
https://pmc.ncbi.nlm.nih.gov › articles › PMC10005407
PubMed Central (PMC) (.gov)
https://pmc.ncbi.nlm.nih.gov › articles › PMC10005407
by X Liang2023Cited by 5 — In this study, sweet potato β-amylase (SPA) was modified by methoxy polyethylene glycol maleimide (molecular weight 5000, Mal-mPEG5000)Read more
mPEG-SPA, mPEG-Succinimidyl Propionate
Biopharma PEG
https://www.biochempeg.com › product › mPEG-SPA
Biopharma PEG
https://www.biochempeg.com › product › mPEG-SPA
mPEG-SPA (mPEG-Succinimidyl Propionate) is an amine pegylation reagent that can react with primary amine groups at basic conditions.Read more
$55 delivery
Methoxy PEG Succinimidyl Acid Ester, mPEG-NHS
Nanocs
https://www.nanocs.net › document › DataSheet
Nanocs
https://www.nanocs.net › document › DataSheet
PDF
Methoxy PEG Succinimidyl Acid Ester, mPEG-NHS ... Catalog Numbers: PG1-SPA-1k, 2k, 5k, 10k, 20k, 30k, 40k. Synonym: NHS PEG, PEG NHS, mPEG SPA, mPEG succinimidyl ...
2-arm Methoxypoly(ethylene glycol) succinimidyl ...
Amerigo Scientific
https://www.amerigoscientific.com › 2-arm-methoxypol...
Amerigo Scientific
https://www.amerigoscientific.com › 2-arm-methoxypol...
2-arm Methoxypoly(ethylene glycol) succinimidyl propionate(PT02) [2-arm PEG-SPA(PT02)] ; Catalog Number: PG01410674SIN ; Mfr. No.: 06022102302; 06022102306; ...Read more
$200 delivery
Methoxy Peg Pa
SINOPEG
https://www.sinopeg.com › methoxy-peg-pa_sp
SINOPEG
https://www.sinopeg.com › methoxy-peg-pa_sp
Methoxypoly(ethylene glycol)succinimidyl propionate. Molecular Weight: 5KDa, 10KDa, 20KDa. Package Size: 1g/bottle, 10g/bottle, 50g/bottle, 100g/bottle.
mPEG-SPA(mPEG-succinimidyl propionate)
ChemicalBook
https://www.chemicalbook.com › ChemicalProductProp...
ChemicalBook
https://www.chemicalbook.com › ChemicalProductProp...
mPEG-SPA(mPEG-succinimidyl propionate) information, including chemical properties, structure, melting point, boiling point, density, formula, ...
Methoxy PEGs for PEGylation - JenKem Technology
JenKem Technology USA
https://jenkemusa.com › methoxy-pegs-for-pegylation
JenKem Technology USA
https://jenkemusa.com › methoxy-pegs-for-pegylation
Mar 25, 2026 — JenKem Technology provides high quality activated methoxy PEGs for PEGylation, with high purity, low polydispersity, and low to no diol content.Read more
People also ask
What is methoxy PEG?
Methoxy PEG amine (mPEG-NH₂) is a monofunctional polyethylene glycol (PEG) derivative with a terminal amine (-NH₂) group, allowing for covalent conjugation to biomolecules, surfaces, or other reactive groups.
Methoxy PEG amine, Mp 5000 - Polysciences
Polysciences
https://polysciences.com › products › methoxy-peg-amin...
Polysciences
https://polysciences.com › products › methoxy-peg-amin...
What solvents is PEG soluble in?
PEG is soluble in water, methanol, ethanol, acetonitrile, benzene, and dichloromethane, and is insoluble in diethyl ether and hexane.
Polyethylene glycol - Wikipedia
Wikipedia
https://en.wikipedia.org › wiki › Polyethylene_glycol
Wikipedia
https://en.wikipedia.org › wiki › Polyethylene_glycol