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    About 9,140,000 results (0.27s) 
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    AI Overview
    Long-acting growth hormone (LAGH) preparations utilize specialized side chains or molecular modifications to extend the half-life of growth hormone (GH), allowing for weekly instead of daily injections. Key technologies include albumin-binding fatty acid side chains (like in Somapacitan) and PEGylation (like in Lonapegsomatropin). 
    Key Long-Acting Growth Hormone Technologies: 
    • Somapacitan (Sogroya): Uses a non-covalent albumin-binding moiety. A single substitution in the peptide backbone (leucine to cysteine at position 101) allows for the attachment of a C16 fatty acid side chain, which binds to endogenous albumin to delay clearance.
    • Lonapegsomatropin (Skytrofa): Employs TransCon technology, which uses a proprietary transient carrier (methoxypolyethylene glycol, or mPEG) linked to the growth hormone. This inactive carrier increases the molecular size to minimize renal excretion.
    • Somatrogon (Ngenla): A fusion protein designed with three copies of the C-terminal peptide (CTP) of human chorionic gonadotropin attached to the hGH molecule, reducing clearance. 
    Common Side Chain Structures and Components: 
    • Fatty Acids: C16 fatty acid moieties (e.g., in Somapacitan) are used to facilitate albumin binding, similar to technology used in insulin detemir.
    • Hydrophilic Spacers: Often used to connect the fatty acid to the protein backbone, enhancing solubility and binding.
    • PEGylation Chains: Polyethylene glycol polymers, such as the mPEG used in TransCon, are used to increase the hydrodynamic volume, protecting the protein. 
    These advancements in modifying the growth hormone molecule are designed to improve patient compliance by reducing injection frequency. 
    • Long-acting Growth Hormones Produced by Conjugation with ...
      Sep 6, 1996 — hGH is a good model system in this regard as much is known about its structure and function (for review see Ref. 4). Simple recept...
      ScienceDirect.com
    • Long-Acting Growth Hormone Preparations in the Treatment of ...
      Non-Covalent Albumin Binding GH Novo Nordisk's (Bagsværd, Denmark) Somapacitan (NNC0195–0092) is rhGH with a single point mutation...
      PubMed Central (PMC) (.gov)
    • Current Status of Long-acting Growth Hormone Therapies
      Sep 19, 2023 — Sogroya (Somapacitan) is a long-acting recombinant human GH derivative with a single substitution in the peptide backbone (leucine...
      Biopharma PEG
    • Long-acting growth hormone for pediatric GHD: insights into ... - PMC
      Jan 28, 2026 — 2.1. ... This approach leverages the exceptional stability and long half-life of human serum albumin (HSA). HSA is a 66.5 kDa plas...
      PubMed Central (PMC) (.gov)
    • Long-Acting Growth Hormone Preparations – Current Status ... - PMC
      Pro-drug formulations The generation of LAGH by binding rhGH reversibly to a long-acting carrier to form a prodrug has been invest...
      PubMed Central (PMC) (.gov)
    • Long acting growth hormone (LAGH), an update - Frontiers
      The FDA has approved, in the fall of 2021, lonapegsomatropin-tcgd (Ascendis), LAGH for once-weekly treatment of growth failure due...
      Frontiers
    • Long-acting growth hormones: innovations in treatment ... - PMC
      Somatrogon is an LAGH fusion protein characterized by fusion of an rhGH with 3 copies of the C-terminal peptide of human chorionic...
      PubMed Central (PMC) (.gov)
    • Rationale for Long-acting Growth Hormone Therapy and ... - PMC
      Mar 19, 2025 — Long-acting Growth Hormones In theory, clinical indications for the use of LAGH formulations include needle phobia in children, no...
      PubMed Central (PMC) (.gov)
    • Long‐acting growth hormone in 2022 - PMC
      Jan 3, 2023 — The benefit of LAGH is to decrease the burden of injections, as GH currently is given daily. The hope for LAGH is to decrease the ...
      PubMed Central (PMC) (.gov)
    • Long-acting Growth Hormones Produced by Conjugation with ...
      Sep 6, 1996 — hGH is a good model system in this regard as much is known about its structure and function (for review see Ref. 4). Simple recept...
      ScienceDirect.com
    • Long-Acting Growth Hormone Preparations in the Treatment of ...
      Non-Covalent Albumin Binding GH Novo Nordisk's (Bagsværd, Denmark) Somapacitan (NNC0195–0092) is rhGH with a single point mutation...
      PubMed Central (PMC) (.gov)
    • Current Status of Long-acting Growth Hormone Therapies
      Sep 19, 2023 — Sogroya (Somapacitan) is a long-acting recombinant human GH derivative with a single substitution in the peptide backbone (leucine...
      Biopharma PEG
    • Long-acting growth hormone for pediatric GHD: insights into ... - PMC
      Jan 28, 2026 — 2.1. ... This approach leverages the exceptional stability and long half-life of human serum albumin (HSA). HSA is a 66.5 kDa plas...
      PubMed Central (PMC) (.gov)
    • Long-Acting Growth Hormone Preparations – Current Status ... - PMC
      Pro-drug formulations The generation of LAGH by binding rhGH reversibly to a long-acting carrier to form a prodrug has been invest...
      PubMed Central (PMC) (.gov)
    • Long acting growth hormone (LAGH), an update - Frontiers
      The FDA has approved, in the fall of 2021, lonapegsomatropin-tcgd (Ascendis), LAGH for once-weekly treatment of growth failure due...
      Frontiers
    Show all
    Dive deeper in AI Mode
    This is for informational purposes only. For medical advice or diagnosis, consult a professional. AI responses may include mistakes. Learn more
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    Long acting growth hormone (LAGH), an update - PMC - NIH


    PubMed Central (PMC) (.gov)
    https://pmc.ncbi.nlm.nih.gov › articles › PMC10569466
    PubMed Central (PMC) (.gov)
    https://pmc.ncbi.nlm.nih.gov › articles › PMC10569466
    by MS Grillo · 2023 · Cited by 25 — They are: (1) Pegylated formulations, (2) Prodrug formulations which are converted into active drug, (3) Nonvalent transient albumin binding GH compounds and (4) ...Read more
    Missing: Chain ‎| Show results with: Chain

    Current Status of Long-acting Growth Hormone Therapies


    Biopharma PEG
    https://www.biochempeg.com › article
    Biopharma PEG
    https://www.biochempeg.com › article
    Sep 19, 2023 — The albumin-binding moiety (side chain) consists of a C16 fatty acid moiety and a hydrophilic spacer chemically conjugated to position 101 of ...Read more

    Long-acting Growth Hormones Produced by Conjugation ...


    ScienceDirect.com
    https://www.sciencedirect.com › science › article › pii
    ScienceDirect.com
    https://www.sciencedirect.com › science › article › pii
    by R Clark · 1996 · Cited by 526 — Our studies show that systematic modification of hGH with PEG leads to systematic changes in physical and biological properties.Read more

    Peptidomimetic Long-Acting Growth Hormone-Releasing ...


    ACS Publications
    https://pubs.acs.org › doi
    ACS Publications
    https://pubs.acs.org › doi
    Apr 13, 2026 — Growth hormone-releasing hormone (GHRH) has shown therapeutic potential in the treatment of various diseases.Read more

    Long-acting growth hormones: innovations in treat


    Annals of Pediatric Endocrinology & Metabolism
    https://e-apem.org › pdf › apem-2448202-101
    Annals of Pediatric Endocrinology & Metabolism
    https://e-apem.org › pdf › apem-2448202-101
    PDF
    by C Rodaro · 2025 · Cited by 7 — Long-acting growth hormones (LAGHs) improve adherence in children with growth hormone deficiency by reducing injection frequency from daily to weekly. LAGHs ...Read more

    Long-Acting Growth Hormone Side Chain [TZ-Ste-SO2- ...


    SINOPEG
    https://www.sinopeg.com › long-acting-growth-hormon...
    SINOPEG
    https://www.sinopeg.com › long-acting-growth-hormon...
    Product Name: Long-Acting Growth Hormone Side Chain Abbreviation: TZ-Ste-SO2-nBu-AEEA-Glu(OH)-Glu(OH)-AEEA-Lys(OH)-COCH2-Cys(OH)Read more
    Long-Acting Growth Hormone Side Chain from www.sinopeg.com

    Growth hormone


    Wikipedia
    https://en.wikipedia.org › wiki › Growth_hormone
    Wikipedia
    https://en.wikipedia.org › wiki › Growth_hormone
    Long acting growth hormone (LAGH) analogues are now available for treating growth hormone deficiency both in children and adults. These are once weekly ...Read more
    Long-Acting Growth Hormone Side Chain from en.wikipedia.org

    Long-acting growth hormones: innovations in treatment ... - PMC


    PubMed Central (PMC) (.gov)
    https://pmc.ncbi.nlm.nih.gov › articles › PMC12061763
    PubMed Central (PMC) (.gov)
    https://pmc.ncbi.nlm.nih.gov › articles › PMC12061763
    by C Rodaro · 2025 · Cited by 7 — Long-acting growth hormones (LAGHs) improve adherence in children with growth hormone deficiency by reducing injection frequency from daily to weekly.Read more

    HGH (Human Growth Hormone): What It Is, Benefits & Side ...


    Cleveland Clinic
    https://my.clevelandclinic.org › health › articles › 2330...
    Cleveland Clinic
    https://my.clevelandclinic.org › health › articles › 2330...
    by HGH Can — Human growth hormone (HGH) is a natural hormone your pituitary gland releases that promotes growth in children, helps maintain normal body structure in adults.Read more
  • Hgh And Growth
  • Hgh And Metabolism
  • Hgh Deficiency In Children

    • Usefulness and Potential Pitfalls of Long-Acting Growth ...


    Frontiers
    https://www.frontiersin.org › fendo.2021.637209 › full
    Frontiers
    https://www.frontiersin.org › fendo.2021.637209 › full
    by KCJ Yuen · 2021 · Cited by 89 — Treatment-related side-effects, mainly related to fluid retention and impaired glucose tolerance, are dose-dependent and related to increased GH ...Read more
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