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CBZ-NH-PEG3-CH2COOH (CAS# 462100-05-6) is a commonly used heterobifunctional PEG linker featuring a Cbz-protected amine and a terminal carboxylic acid. It is widely used in PROTAC synthesis, drug delivery, and pharmaceutical research to connect ligands, with a triethylene glycol spacer to improve solubility.
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Cbz-NH-PEG3-CH2COOH | PROTAC Linkers
MedchemExpress.com
https://www.medchemexpress.com › cbz-nh-peg3-ch2cooh
MedchemExpress.com
https://www.medchemexpress.com › cbz-nh-peg3-ch2cooh
Cbz-NH-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. For research use only. We ...Read more
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Cbz-NH-peg3-CH2cooh | C16H23NO7 | CID 15544432
National Institutes of Health (.gov)
https://pubchem.ncbi.nlm.nih.gov › compound
National Institutes of Health (.gov)
https://pubchem.ncbi.nlm.nih.gov › compound
Cbz-NH-peg3-CH2cooh | C16H23NO7 | CID 15544432 - structure, chemical names, physical and chemical properties, classification, patents, literature, ...
Cbz-NH-PEG3-CH2COOH | 462100-05-6
Sigma-Aldrich
https://www.sigmaaldrich.com › product › chemscenell...
Sigma-Aldrich
https://www.sigmaaldrich.com › product › chemscenell...
Cbz-NH-PEG3-CH2COOH; CAS Number: 462100-05-6; Synonyms: 3-oxo-1-phenyl-2,7,10,13-tetraoxa-4-azapentadecan-15-oic acid; Linear Formula: C16H23O7N1; ...
CBZ-NH-PEG3-CH2CH2COOH
PurePEG
https://purepeg.com › ... › CBZ-PEG-Propionic acid
PurePEG
https://purepeg.com › ... › CBZ-PEG-Propionic acid
CBZ-PEG-Propionic acid. CBZ-NH-PEG3-CH2CH2COOH ; CAS Number. 1310327-18-4 ; Molecular Formula. C17H25NO7 ; Molecular Weight. 355.38 ; Appearance. Viscous Liquid.Read more
$140.00 to $470.00In stock$45 delivery
1310327-18-4, CBZ-NH-PEG3-COOH
Biopharma PEG
https://www.biochempeg.com › product › CBZ-NH-PEG...
Biopharma PEG
https://www.biochempeg.com › product › CBZ-NH-PEG...
CBZ-NH-PEG3-COOH features a CBZ-protected amino group and a terminal carboxylic acid. The carboxylic acid allows for efficient coupling reactions with primary ...Read more
$55 delivery
Cbz-NH-PEG3-CH2COOH | 462100-05-6
Sigma-Aldrich
https://www.sigmaaldrich.com › targetmolchemicalsinc
Sigma-Aldrich
https://www.sigmaaldrich.com › targetmolchemicalsinc
Cbz-NH-PEG3-CH2COOH ; Synonym(s): 3-oxo-1-phenyl-2,7,10,13-tetraoxa-4-azapentadecan-15-oic acid ; MSDS. https://www.targetmol.com/compound/Cbz-NH-PEG3-CH2COOH ...
CBZ-NH-PEG3-CH2COOH
PurePEG
https://purepeg.com › Products › CBZ-PEG-Acetic acid
PurePEG
https://purepeg.com › Products › CBZ-PEG-Acetic acid
CBZ-PEG-Acetic acid. CBZ-NH-PEG3-CH2COOH ; Molecular Formula. C16H23NO7 ; Molecular Weight. 341.36 ; Appearance. Viscous Liquid ; Storage. -18℃ for long term ...Read more
Cbz-NH-PEG3-CH2COOH 250mg
Dana Bioscience
https://danabiosci.com › products
Dana Bioscience
https://danabiosci.com › products
Cbz-NH-PEG3-CH2COOH 250mg. Cbz-NH-PEG3-CH2COOH 250mg. Regular price $17.00 USD. Regular price Sale price $17.00 USD. Unit price / per. Sale Sold out. Shipping ...Read more
CBZ-NH-PEG3-CH2COOH [C16H23NO7] Cas:462100-05-6
SINOPEG
https://www.sinopeg.com › CBZ-NH-PEG
SINOPEG
https://www.sinopeg.com › CBZ-NH-PEG
C16H23NO7 · Product Name:CBZ-NH-PEG3-CH2COOH · CAS No.:462100-05-6 · M.F.:C16H23NO7 · M.W:341.36 · Storage:-18℃ for long term storage,avoid light · Purity:>95%.Read more
Stability of Cbz-NH-PEG3-CH2COOH
Benchchem
https://www.benchchem.com › pdf › Technical_S...
Benchchem
https://www.benchchem.com › pdf › Technical_S...
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The Cbz group of Cbz-NH-PEG3-CH2COOH can be cleaved under strong acidic conditions.[5]. Reagents such as hydrogen bromide (HBr) in acetic acid and strong Lewis ...Read more
People also ask
What is a Cbz group?
Among the widely used protecting groups for amines and amino acids, the benzyloxycarbonyl (Cbz) group1 is extensively used since it can be easily removed by catalytic hydrogenation. The Cbz group is stable to basic and most aqueous acidic conditions.
Aqueous phase mono-protection of amines and amino acids as N ...
ScienceDirect.com
https://www.sciencedirect.com › article › abs › pii
ScienceDirect.com
https://www.sciencedirect.com › article › abs › pii
What is the mechanism of Cbz reaction?
Cbz protection is typically performed with Cbz-Cl either under Schotten-Baumann conditions (carbonate base) or with an organic base. The mechanism is attack of the nucleophilic amine to the highly reactive chloroformate. As chloride is the leaving group, the reaction liberates HCl and requires some base.
N-Cbz Protection & Deprotection Mechanism - Total Synthesis
Total Synthesis
https://total-synthesis.com › cbz-protecting-group
Total Synthesis
https://total-synthesis.com › cbz-protecting-group