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    Buy Bulk – Cooling Agent WS-12 | Manufacturer-Supplier
    WS-12 (CAS 68489-09-8) is a potent, synthetic cooling agent used in e-liquids to provide an immediate, intense, and long-lasting cooling sensation, particularly in the nasal cavity. As a high-affinity TRPM8 receptor agonist, it is often preferred over menthol for its lack of odor, taste, and bitterness, while offering superior, long-lasting, and cleaner-tasting effects. 
    Key Characteristics of WS-12 in E-Liquids: 
    • Intensity & Duration: Offers one of the strongest initial cooling impacts, often described as more intense than WS-3 or WS-23, with a long-lasting effect.
    • Flavor Profile: Odorless and tasteless, allowing it to be used without affecting the flavor profile of the e-liquid.
    • Mechanism: It acts as a selective activator of the TRPM8 receptor (cold receptor), creating a sensation of cold without actually reducing temperature.
    • Usage: Usually added to e-liquid formulations in low concentrations to add a "frozen" or "ice" effect. 
    Benefits Over Other Coolants: 
    • Long-Lasting: Known for providing a more enduring cool feeling than other agents like WS-23.
    • No Menthol Taste: Does not produce the harshness or distinct minty taste of traditional menthol. 
    WS-12 is generally used in "ice" or "frozen" flavored e-liquids, particularly in fruit and beverage profiles, to enhance the refreshing, cold sensation. 
    • A Brief Guide to Cooling Agents in E-Liquids - Hangsen
      Dec 16, 2024 — WS-12 is known for its strong and immediate cooling impact. It offers one of the most potent cooling sensations among synthetic ag...
      Hangsen International Group
    • Symcool® Cooling Agents - Symrise
      to avoid issues that result from insufficient mixing of solids. offers one of the strongest initial cooling impacts and a signific...
      Symrise
    • Cooling Agent WS-12 - FFC / Alfa Chemistry
      WS-12, a derivative of menthol, is an effective TRPM8 agonist and acts as a cooling agent. It strongly activates TRPM8 at low micr...
      Alfa Chemistry
    • Cooling Agent Ws-23 Ws-3 Ws-5 Ws-12 with High Quality - Aogubio
      Advantages. 1. Continuous and long lasting cooling and refreshing effect, having no hot, harsh and stinging sensation of Menthol a...
      Aogubio
    • WS-12 = 98 HPLC, powder 68489-09-8 - Sigma-Aldrich
      WS-12 is a high-affinity, selective TRPM8 (cold menthol receptor 1; CMR1) agonist. WS-12 is a high-affinity, selective TRPM8 (cold...
      Sigma-Aldrich
    • Cooling Agent WS-12 - Koolada Flavor Concentrate - Vegan - Sasami
      With its odorless and tasteless formula, this cooling agent harmonizes perfectly with all flavors and textures without masking the...
      Amazon.com
    • WS-23, WS-5, WS-12, WS-3 vs Menthol for Food & Beverage
      Aug 6, 2025 — WS-12 offers the longest-lasting cooling effect among WS agents—up to 30+ minutes—and is perfect when you want a lasting freshness...
      TasteNest
    • WS Series Cooling Agents - Foreverest Resources Ltd
      Recommended Application. ... 2. WS-12 withstands heat up to 200°C without losing cooling power; serves as mint flavouring in oral ...
      Foreverest Resources Ltd
    • A Brief Guide to Cooling Agents in E-Liquids - Hangsen
      Dec 16, 2024 — WS-12 is known for its strong and immediate cooling impact. It offers one of the most potent cooling sensations among synthetic ag...
      Hangsen International Group
    • Symcool® Cooling Agents - Symrise
      to avoid issues that result from insufficient mixing of solids. offers one of the strongest initial cooling impacts and a signific...
      Symrise
    • Cooling Agent WS-12 - FFC / Alfa Chemistry
      WS-12, a derivative of menthol, is an effective TRPM8 agonist and acts as a cooling agent. It strongly activates TRPM8 at low micr...
      Alfa Chemistry
    Show all
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    Web results

    WS-12


    Enzo Life Sciences
    https://www.enzo.com › Shop
    Enzo Life Sciences
    https://www.enzo.com › Shop
    WS-12 ; Formula. C18H27NO ; Identity. Determined by 1H-NMR and MS. ; MW. 289.4 ; Purity. ≥98% (HPLC) ; Solubility. Soluble in 100% ethanol, methanol, ethyl acetate, ...Read more
    Missing: Liquid ‎| Show results with: Liquid

    Cooling Agent WS-12 - Koolada Flavor Concentrate - Vegan


    Amazon.com
    https://www.amazon.com › Cooling-Agent-WS-12-Koo...
    Amazon.com
    https://www.amazon.com › Cooling-Agent-WS-12-Koo...
    Cooling Agent WS-12 · dissolved in ethanol · provides gentle · long-lasting cooling without burning. Perfect for drinks · confectionery.Read more

    Cooling Agents WS-12


    Foreverest Resources Ltd
    https://foreverest.net › Other Specialty Chemicals
    Foreverest Resources Ltd
    https://foreverest.net › Other Specialty Chemicals
    It offers the strong cooling effect, rated at strength 3.5. This effect lasts up to 36 minutes, providing ample time for a refreshing cooling experience. WS-12 ...Read more

    A Brief Guide to Cooling Agents in E-Liquids


    Hangsen International Group
    https://www.hangsen.com › blog-knowledge › Cooling-...
    Hangsen International Group
    https://www.hangsen.com › blog-knowledge › Cooling-...
    Dec 16, 2024 — ... (WS-12). WS-12 is known for its strong and immediate cooling impact. It offers one of the most potent cooling sensations among synthetic ...Read more

    WS-23 vs WS-12 vs WS-3: The Ultimate Cooling Agent ...


    Xi'an Taima Biological Engineering Co. Ltd
    https://www.taimacn.com › new › ws23-vs-ws12-vs-ws3-...
    Xi'an Taima Biological Engineering Co. Ltd
    https://www.taimacn.com › new › ws23-vs-ws12-vs-ws3-...
    8 days ago — Discover the technical differences between cooling agents WS-23, WS-12, and WS-3. Learn their impact areas, cooling duration, and blending ...

    WS-12 (1R,2S,5R)-N-(4-methoxyphenyl)


    The Good Scents Company
    https://www.thegoodscentscompany.com › data
    The Good Scents Company
    https://www.thegoodscentscompany.com › data
    Food Additive: Functional use(s) - flavor enhancers, flavoring agents. Has a minty type odor and an cooling type flavor.
    People also ask
    What is the cooling agent for e-liquid?
    WS-23 is a synthetic menthol-like cooling agent widely used to enhance the appeal of e-cigs and to suppress the harshness and bitterness of other e-cig constituents.

    E-cigarette synthetic cooling agent WS-23 and nicotine aerosols ... - PMC


    PMC - NIH
    https://pmc.ncbi.nlm.nih.gov › articles › PMC9742947
    PMC - NIH
    https://pmc.ncbi.nlm.nih.gov › articles › PMC9742947
    What is a WS3 cooling agent?
    An error has occurred. Please try again later.
    What is the most used cooling agent?
    Common cooling agents include water, salt water, ethan glycol aqueous solution, heat conduction oil, etc.

    What are the commonly used coolant? - ECHEMI


    Echemi
    https://www.echemi.com › community › what-are-the-co...
    Echemi
    https://www.echemi.com › community › what-are-the-co...
    What is the price of WS-23 cooling agent in India?
    WS-23 COOLING LIQUID AGENT 10% at ₹ 1800/kg | Food Additive in Vadodara | ID: 2858431689255.

    WS-23 COOLING LIQUID AGENT 10% at ₹ 1800/kg - IndiaMART


    IndiaMART
    https://www.indiamart.com › proddetail › ws-23-cooling...
    IndiaMART
    https://www.indiamart.com › proddetail › ws-23-cooling...

    Web results

    Anyone else absolutely SICK of cooling agents in vape ...


    Reddit · r/Vaping
    90+ comments · 3 months ago
    Reddit · r/Vaping
    90+ comments · 3 months ago
    I love fruit flavours but nowadays it seems ALL OF THEM have these cooling agents in them even when not marked as “ice”.Read more

    WS-23 WS-3 WS-12 Cooling Agent Powder


    Anhui Chinaherb Flavors&Fragrances Co.,Ltd.
    https://www.cnherbflavor.com › ws-23-ws-3-ws-12-cooli...
    Anhui Chinaherb Flavors&Fragrances Co.,Ltd.
    https://www.cnherbflavor.com › ws-23-ws-3-ws-12-cooli...
    Cooling Agent WS-23 has a high cooling effect without other unpleasant feelings such as bitterness, burning, stinging or tingling sensations.Read more

    Symcool® Cooling Agents


    Symrise
    https://www.symrise.com › Aroma_molecules › sy...
    Symrise
    https://www.symrise.com › Aroma_molecules › sy...
    PDF
    WS-12 has been found to cool primarily at the front of the tongue. Symcool® WS-23. Butanamide, N,2,3-trimethyl-2-(1-methylethyl)-.Read more
    6 pages

    Ice Flavors and Non-Menthol Synthetic Cooling Agents in E ...


    National Institutes of Health (.gov)
    https://pmc.ncbi.nlm.nih.gov › articles › PMC9613790
    National Institutes of Health (.gov)
    https://pmc.ncbi.nlm.nih.gov › articles › PMC9613790
    by AM Leventhal · 2022 · Cited by 72 — This paper reviews the background, chemistry, toxicology, marketing, user perceptions, use prevalence, and policy implications of e-cigarette products with ice ...Read more
    People also search for
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