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    AI Overview
    Guanidine hydrochloride is a white crystalline solid that serves as a key pharmaceutical intermediate in the synthesis of various organic compounds, including the anti-anemia drug folic acid and sulfonamides . Beyond its role as a building block, it is also a widely used protein denaturing agent in biochemical research for processes like nucleic acid extraction and protein analysis.
    Applications in Pharmaceuticals:
    • Synthesis of Folic Acid and Sulfonamides:
      Opens in new tab
      Guanidine hydrochloride is a critical raw material for the production of these important drugs.
    • Drug Intermediate for Other Compounds:
      Opens in new tab
      It is used as an intermediate in the synthesis of other organic compounds, which may have pharmaceutical applications.
    Other Key Uses:
    • Protein Denaturing Agent :
      Opens in new tab
      In biochemical and molecular biology research, it is used to unfold proteins and nucleic acids.
    • Nucleic Acid Extraction :
      Opens in new tab
      It is used to disrupt cell membranes and inactivate enzymes, facilitating the separation of nucleic acids from proteins.
    • Protein Renaturation :
      Opens in new tab
      It can be used to restore the active state of denatured proteins.
    • Chaotropic Agent :
      Opens in new tab
      It increases the solubility of hydrophobic molecules by disrupting hydrogen bonds and protein structure.
    • Guanidine HCl 6M GMP Denaturant Solution - BioSpectra
      Guanidine Hydrochloride 6M solution can be used to denature proteins which become randomly coiled with no residual structure. This...
      BioSpectra
    • GUANIDINE HCl Excipient Buffer - BioSpectra
      Guanidine Hydrochloride Buffer is a strong protein denaturant that functions as a chaotropic agent. As a denaturant, it acts to un...
      BioSpectra
    Physical Properties:
    • Appearance: A white crystalline substance or lumps.
    • Solubility: Highly soluble in water. At 20°C, about 228g can be dissolved in 100g of water.
    • Insolubility: It is almost insoluble in acetone, benzene, and ether.
    • Guanidine hydrochloride CAS 50-01-1
      Description. Guanidine hydrochloride, often abbreviated as GuHCl, is a chemical compound with a broad range of applications. It is...
      Suzhou Yacoo Science Co., Ltd.
    • The Uses of guanidine hydrochloride - ChemicalBook
      Background. Guanidine hydrochloride is an organic substance with the chemical formula CH6ClN3, white or yellowish lumps. It is use...
      ChemicalBook
    • Guanidine Hydrochloride For Pharmaceuticals
      Guanidine Hydrochloride is a kind of white odorless crystal. It is an intermediate for medicine, pesticide, dye and other organic ...
      Shizuishan Pengsheng Chemical Co., Ltd
    • Guanidine hydrochloride, 50-01-1, High-Purity, G4505, Sigma ...
      Guanidine Hydrochloride is a potent protein denaturant extensively utilized in the purification of proteins and nucleic acids. Wid...
      Sigma-Aldrich
    • Guanidine hydrochloride CAS 50-01-1
      Description. Guanidine hydrochloride, often abbreviated as GuHCl, is a chemical compound with a broad range of applications. It is...
      Suzhou Yacoo Science Co., Ltd.
    • The Uses of guanidine hydrochloride - ChemicalBook
      Background. Guanidine hydrochloride is an organic substance with the chemical formula CH6ClN3, white or yellowish lumps. It is use...
      ChemicalBook
    • Guanidine Hydrochloride For Pharmaceuticals
      Guanidine Hydrochloride is a kind of white odorless crystal. It is an intermediate for medicine, pesticide, dye and other organic ...
      Shizuishan Pengsheng Chemical Co., Ltd
    • Show all
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    Guanidine hydrochloride CAS 50-01-1


    Suzhou Yacoo Science Co., Ltd.
    https://www.yacooscience.com › guanidine-hydrochlorid...
    Suzhou Yacoo Science Co., Ltd.
    https://www.yacooscience.com › guanidine-hydrochlorid...
    (1) Intermediates: Guanidine hydrochloride serves as a crucial intermediate in the synthesis of organic compounds , particularly in the pharmaceutical and ...

    Guanidine hydrochloride CAS No.:50-01-1


    Jinan Qinmu Fine Chemical Co., Ltd.
    https://www.qinmuchem.com › guanidine-hydrochloride...
    Jinan Qinmu Fine Chemical Co., Ltd.
    https://www.qinmuchem.com › guanidine-hydrochloride...
    Mainly used as an intermediate for medicines , and an important raw material for the manufacture of sulfadiazine, sulfamethazine, sulfamethazine and folic acidIt ...

    Guanidine hydrochloride, 50-01-1, High-Purity, G4505, ...


    Sigma-Aldrich
    https://www.sigmaaldrich.com › product › sigma
    Sigma-Aldrich
    https://www.sigmaaldrich.com › product › sigma
    Guanidine Hydrochloride is a potent protein denaturant extensively utilized in the purification of proteins and nucleic acids. Widely recognized for its ...
    $49.40 · In stock · 5.0 (1) · $23.16 delivery
    Missing: Intermediates ‎| Show results with: Intermediates

    Guanidine Hydrochloride Parenteral Excipient LBLE


    BioSpectra
    https://www.biospectra.us › guanidine_hcl_parenteral_e...
    BioSpectra
    https://www.biospectra.us › guanidine_hcl_parenteral_e...
    Guanidine Hydrochloride Parenteral Excipient LBLE is commonly used in the purification of RNA by dissociating the RNA into its nucleic acids and protein ...

    Guanidine Hydrochloride CAS 50-01-1


    Home Sunshine Pharma
    https://www.hsppharma.com › apis-and-intermediates
    Home Sunshine Pharma
    https://www.hsppharma.com › apis-and-intermediates
    Guanidine HCl, the crystalline compound of strong alkalinity formed by the oxidation of guanine, is a normal product of protein metabolism and a protein ...

    The Uses of guanidine hydrochloride


    ChemicalBook
    https://www.chemicalbook.com › article › the-uses-of-g...
    ChemicalBook
    https://www.chemicalbook.com › article › the-uses-of-g...
    Guanidine hydrochloride can be used as pharmaceuticals , pesticides, dyes and other organic synthesis intermediates .

    Guanidine Hydrochloride | CH5N3.ClH | CID 5742


    National Institutes of Health (NIH) | (.gov)
    https://pubchem.ncbi.nlm.nih.gov › compound › Guani...
    National Institutes of Health (NIH) | (.gov)
    https://pubchem.ncbi.nlm.nih.gov › compound › Guani...
    Guanidine Hydrochloride is the hydrochloride salt form of guanidine , a strong basic compound with parasympathomimetic activity.
    Missing: Intermediates ‎| Show results with: Intermediates

    Guanidine HCl 6M GMP Denaturant Solution - BioSpectra


    BioSpectra
    https://biospectra-new.useast01.umbraco.io › guanidine...
    BioSpectra
    https://biospectra-new.useast01.umbraco.io › guanidine...
    Guanidine Hydrochloride 6M GMP solution can be used to denature proteins which become randomly coiled with no residual structure.

    Guanidine Hydrochloride, ULTROL® Grade API ...


    PharmaCompass – Grow Your Pharma Business Digitally
    https://www.pharmacompass.com › guanidine-hydrochl...
    PharmaCompass – Grow Your Pharma Business Digitally
    https://www.pharmacompass.com › guanidine-hydrochl...
    PharmaCompass offers a list of GUANIDINE HYDROCHLORIDE API API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, ...

    Scholarly articles for Pharmaceutical Intermediates Guanidine hydrochloride

    Guanidine chemistry - ‎ Ishikawa - Cited by 137
    Guanidine hydrochloride stabilization of a partially … - ‎ Morjana - Cited by 101
    Effects of urea and guanidine · HCl on the folding and … - ‎ Creighton - Cited by 100

    Guanidine hydrochloride CAS 50-01-1


    Sinocure Chemical Group
    https://pharm.sinocurechem.com › guanidine-hydrochl...
    Sinocure Chemical Group
    https://pharm.sinocurechem.com › guanidine-hydrochl...
    Mainly used as an intermediate in medicine, an important raw material for the manufacture of sulfamethazine, sulfamethazine, and folic acid. Packaging and ...

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