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WS-23 (N,2,3-trimethyl-2-isopropylbutanamide) is a synthetic, high-purity crystalline cooling agent commonly marketed for its intense, long-lasting cooling effect without the flavor, odor, or bitterness of menthol. It is used extensively in food, personal care, and pharmaceutical products, providing a "round" cooling sensation, often described as a "frozen" rather than "minty" feel.
Key Characteristics & Properties
- Cooling Mechanism: Stimulates TRPM8 receptors to create a sensation of cold without affecting actual temperature, delivering a fast-acting cooling effect that is smoother than WS-3 or menthol.
- Appearance/Form: White, odourless, crystalline powder (CAS: 51115-67-4).
- Purity & Solubility: Often available at >99% purity. It is sparingly soluble in water but highly soluble in propylene glycol (PG) and ethanol.
- Stability: High heat resistance (up to 200°C), making it suitable for baked goods.
Medical and Personal Care Applications
"Medical grade" WS-23 refers to high-purity, food-safe or pharmaceutical-safe, synthetic powder used in:
- Topical Preparations: Used in analgesic creams, balms, ointments, and cooling patches for a soothing sensation.
- Oral Care: Found in toothpastes, mouthwashes, and oral sprays for a clean sensation.
- Pharmaceuticals: Used to improve the palatability of oral medications and in cough syrups.
Safety and Regulatory Information
- Regulatory Status: Considered generally safe (GRAS) for use in food, cosmetics, and pharmaceutical applications when used within recommended levels.
- Sensory Effects: It does not produce the burning, harsh, or numbing irritation of menthol or peppermint.
- Safety Precautions: As a highly concentrated material, it can be irritating to skin and eyes, and requires caution with appropriate personal protective equipment (PPE).
Purchase Options
WS-23 is available in crystalline powder (e.g., CAS 51115-67-4) or pre-dissolved liquid concentrates (often 30%) from chemical suppliers and flavor distributors.
- WS-23 Powder 500g from Extract Consultants: High-purity, food-grade synthetic cooling agent.
- FlavorJungle WS-23 Powder - CAS 51115-67-4: Odourless, smooth-cooling powder used for edibles and beverages.
- 30% WS-23 Cooling Liquid Concentrate from FlavorJungle: Available in various sizes, pre-dissolved for easier mixing.
Are you looking for WS-23 to use in a topical, food, or another specific application?
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Web results
Pure Crystalline WS-23 - Cooling Agent - Koolada - Powder
Amazon.com
https://www.amazon.com › WS-23-Cooling-crystalline-...
Amazon.com
https://www.amazon.com › WS-23-Cooling-crystalline-...
The crystalline cooling agent WS-23 ensures long-lasting; consistent freshness without burning. Ideal for drinks; desserts and baked goods.Read more
Symcool® WS-23 (Cooling Agent)
Pure Ingredients US
https://pureingredients.us › Shop › Formulation Aids
Pure Ingredients US
https://pureingredients.us › Shop › Formulation Aids
Symcool® WS-23 is a synthetic cooling agent that delivers a refreshing, long-lasting cooling effect in personal care formulations.
$229.99Free delivery10-day returns
WS-23 30% Cooling Solution
Flavor Jungle
https://flavorjungle.com › products › ws23
Flavor Jungle
https://flavorjungle.com › products › ws23
Our 30% WS-23 solution is a clean, long-lasting cooling agent that adds a strong icy feeling without any mint taste or unwanted flavor changes. What WS-23 ...Read more
$6.99 to $249.99In stock$14.95 delivery7-day returns
Cooling agent WS-23
Titanos Group
https://www.titanos.com › product-72342414794162176
Titanos Group
https://www.titanos.com › product-72342414794162176
Cooling agent WS-23 can offer continuous and long-lasting cooling and refreshing effect without the heat, sting and sting of peppermint and/or peppermint.
Cooling Agent WS-23
Alfa Chemistry
https://ffc.alfa-chemistry.com › ... › Cooling Agents
Alfa Chemistry
https://ffc.alfa-chemistry.com › ... › Cooling Agents
WS-23 is a synthetic food grade cooling agent known for its intense cooling sensation. It provides a similar cooling effect to menthol, but without the ...Read more
What is WS-23 Cooling Agent?
Anhui Chinaherb Flavors&Fragrances Co.,Ltd.
https://www.cnherbflavor.com › blog › what-is-ws-23-co...
Anhui Chinaherb Flavors&Fragrances Co.,Ltd.
https://www.cnherbflavor.com › blog › what-is-ws-23-co...
Jan 10, 2025 — WS-23 belongs to a class of synthetic cooling agents designed to mimic the cooling effect of menthol without altering the flavor profile of the product.Read more
People also ask
Web results
E-cigarette synthetic cooling agent WS-23 and nicotine ... - PMC
PubMed Central (PMC) (.gov)
https://pmc.ncbi.nlm.nih.gov › articles › PMC9742947
PubMed Central (PMC) (.gov)
https://pmc.ncbi.nlm.nih.gov › articles › PMC9742947
by M Manevski2022Cited by 13 — WS-23 is a synthetic menthol-like cooling agent widely used to enhance the appeal of e-cigs and to suppress the harshness and bitterness of other e-cig ...Read more
Cooling Agent WS-23
Fluid Science
https://www.fluidscienceltd.com › Products
Fluid Science
https://www.fluidscienceltd.com › Products
Cooling Agent WS-23 is a flavouring additive, often used to create a cooling sensation in products such as E-Liquids, Food & Beverages, Chewing Gum, & more.
£1,470.00In stock
What Is Flavor WS-23 Cooling Agent And Use For?
topinchem.com
https://www.topinchem.com › what-is-flavor-ws-23-cooli...
topinchem.com
https://www.topinchem.com › what-is-flavor-ws-23-cooli...
Jun 2, 2023 — It is a white crystalline powder that has a cooling effect similar to menthol but without the associated taste or odor. WS-23 is considered to ...Read more
The role of synthetic coolants, WS-3 and WS-23, in ...
ScienceDirect.com
https://www.sciencedirect.com › science › article › pii
ScienceDirect.com
https://www.sciencedirect.com › science › article › pii
by S Yogeswaran2022Cited by 20 — Synthetic cooling agents (WS-23 and WS-3) provide a cooling sensation. Coolants in e-cigarettes modify acellular and ROS levels in lung epithelial cells.Read more