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    AI Overview
    WS-23 (N,2,3-trimethyl-2-isopropylbutanamide) is a synthetic, high-purity crystalline cooling agent commonly marketed for its intense, long-lasting cooling effect without the flavor, odor, or bitterness of menthol. It is used extensively in food, personal care, and pharmaceutical products, providing a "round" cooling sensation, often described as a "frozen" rather than "minty" feel. 
    Key Characteristics & Properties 
    • Cooling Mechanism: Stimulates TRPM8 receptors to create a sensation of cold without affecting actual temperature, delivering a fast-acting cooling effect that is smoother than WS-3 or menthol.
    • Appearance/Form: White, odourless, crystalline powder (CAS: 51115-67-4).
    • Purity & Solubility: Often available at >99% purity. It is sparingly soluble in water but highly soluble in propylene glycol (PG) and ethanol.
    • Stability: High heat resistance (up to 200°C), making it suitable for baked goods. 
    Medical and Personal Care Applications 
    "Medical grade" WS-23 refers to high-purity, food-safe or pharmaceutical-safe, synthetic powder used in: 
    • Topical Preparations: Used in analgesic creams, balms, ointments, and cooling patches for a soothing sensation.
    • Oral Care: Found in toothpastes, mouthwashes, and oral sprays for a clean sensation.
    • Pharmaceuticals: Used to improve the palatability of oral medications and in cough syrups. 
    Safety and Regulatory Information 
    • Regulatory Status: Considered generally safe (GRAS) for use in food, cosmetics, and pharmaceutical applications when used within recommended levels.
    • Sensory Effects: It does not produce the burning, harsh, or numbing irritation of menthol or peppermint.
    • Safety Precautions: As a highly concentrated material, it can be irritating to skin and eyes, and requires caution with appropriate personal protective equipment (PPE). 
    Purchase Options 
    WS-23 is available in crystalline powder (e.g., CAS 51115-67-4) or pre-dissolved liquid concentrates (often 30%) from chemical suppliers and flavor distributors. 
    • WS-23 Powder 500g from Extract Consultants: High-purity, food-grade synthetic cooling agent.
    • FlavorJungle WS-23 Powder - CAS 51115-67-4: Odourless, smooth-cooling powder used for edibles and beverages.
    • 30% WS-23 Cooling Liquid Concentrate from FlavorJungle: Available in various sizes, pre-dissolved for easier mixing. 
    Are you looking for WS-23 to use in a topical, food, or another specific application? 
    • Cooling Agent WS-23 - FFC / Alfa Chemistry
      Jul 1, 2024 — Cooling Agent WS-23. WS-23 is a synthetic food grade cooling agent known for its intense cooling sensation. It provides a similar ...
      Alfa Chemistry
    • Cooling Agents WS-23 - Foreverest Resources Ltd
      Cooling Agents WS-23. ... WS-23 (2-Isopropyl-N,2,3-trimethylbutanamide) is renowned for its clean and long-lasting cooling effect ...
      Foreverest Resources Ltd
    • Go to product viewer dialog for this item.
      WS-23 Powder - CAS 51115-67-4
      WS-23 is a cooling agent that has little or no odor or taste. As opposed to other cooling agents, WS-23 is more round and smooth i...
      Google
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    Web results

    Pure Crystalline WS-23 - Cooling Agent - Koolada - Powder


    Amazon.com
    https://www.amazon.com › WS-23-Cooling-crystalline-...
    Amazon.com
    https://www.amazon.com › WS-23-Cooling-crystalline-...
    The crystalline cooling agent WS-23 ensures long-lasting; consistent freshness without burning. Ideal for drinks; desserts and baked goods.Read more

    Symcool® WS-23 (Cooling Agent)


    Pure Ingredients US
    https://pureingredients.us › Shop › Formulation Aids
    Pure Ingredients US
    https://pureingredients.us › Shop › Formulation Aids
    Symcool® WS-23 is a synthetic cooling agent that delivers a refreshing, long-lasting cooling effect in personal care formulations.
    $229.99 · Free delivery · 10-day returns
    Missing: Grade ‎| Show results with: Grade

    WS-23 30% Cooling Solution


    Flavor Jungle
    https://flavorjungle.com › products › ws23
    Flavor Jungle
    https://flavorjungle.com › products › ws23
    Our 30% WS-23 solution is a clean, long-lasting cooling agent that adds a strong icy feeling without any mint taste or unwanted flavor changes. What WS-23 ...Read more
    $6.99 to $249.99 · In stock · 5.0(24) · $14.95 delivery · 7-day returns
    Missing: Medical ‎| Show results with: Medical

    Cooling agent WS-23


    Titanos Group
    https://www.titanos.com › product-72342414794162176
    Titanos Group
    https://www.titanos.com › product-72342414794162176
    Cooling agent WS-23 can offer continuous and long-lasting cooling and refreshing effect without the heat, sting and sting of peppermint and/or peppermint.
    Missing: Medical ‎| Show results with: Medical

    Cooling Agent WS-23


    Alfa Chemistry
    https://ffc.alfa-chemistry.com › ... › Cooling Agents
    Alfa Chemistry
    https://ffc.alfa-chemistry.com › ... › Cooling Agents
    WS-23 is a synthetic food grade cooling agent known for its intense cooling sensation. It provides a similar cooling effect to menthol, but without the ...Read more
    Missing: Medical ‎| Show results with: Medical

    What is WS-23 Cooling Agent?


    Anhui Chinaherb Flavors&Fragrances Co.,Ltd.
    https://www.cnherbflavor.com › blog › what-is-ws-23-co...
    Anhui Chinaherb Flavors&Fragrances Co.,Ltd.
    https://www.cnherbflavor.com › blog › what-is-ws-23-co...
    Jan 10, 2025 — WS-23 belongs to a class of synthetic cooling agents designed to mimic the cooling effect of menthol without altering the flavor profile of the product.Read more
    Missing: Medical ‎| Show results with: Medical
    People also ask
    What is WS-23 cooling agent?
    An error has occurred. Please try again later.
    What is the price of WS-23 cooling agent?
    WS-23 COOLING LIQUID AGENT 10% at ₹ 1800/kg | Food Additive in Vadodara | ID: 2858431689255.

    WS-23 COOLING LIQUID AGENT 10% at ₹ 1800/kg - IndiaMART


    IndiaMART
    https://www.indiamart.com › proddetail › ws-23-cooling...
    IndiaMART
    https://www.indiamart.com › proddetail › ws-23-cooling...
    Is WS-23 safe?
    An error has occurred. Please try again later.
    What is the INCI name for WS-23 cooling agent?
    Methyl Diisopropyl Propionamide
    Trade Name: WS-23. INCI Name: Methyl Diisopropyl Propionamide. CAS Number: 51115-67-4.

    WS-23 (Cooling agent) สารให้ความเย็น ลงสูตร skin care และ Oral care - พิษ ...


    WS-23 สารให้ความเย็น ลงสูตร skin care และ Oral care - พิษ ...
    https://www.phitsanuchemicals.com › product › ws-23-c...
    WS-23 สารให้ความเย็น ลงสูตร skin care และ Oral care - พิษ ...
    https://www.phitsanuchemicals.com › product › ws-23-c...

    Web results

    E-cigarette synthetic cooling agent WS-23 and nicotine ... - PMC


    PubMed Central (PMC) (.gov)
    https://pmc.ncbi.nlm.nih.gov › articles › PMC9742947
    PubMed Central (PMC) (.gov)
    https://pmc.ncbi.nlm.nih.gov › articles › PMC9742947
    by M Manevski · 2022 · Cited by 13 — WS-23 is a synthetic menthol-like cooling agent widely used to enhance the appeal of e-cigs and to suppress the harshness and bitterness of other e-cig ...Read more
    Missing: Grade ‎| Show results with: Grade

    Cooling Agent WS-23


    Fluid Science
    https://www.fluidscienceltd.com › Products
    Fluid Science
    https://www.fluidscienceltd.com › Products
    Cooling Agent WS-23 is a flavouring additive, often used to create a cooling sensation in products such as E-Liquids, Food & Beverages, Chewing Gum, & more.
    £1,470.00 · In stock
    Missing: Medical ‎| Show results with: Medical

    What Is Flavor WS-23 Cooling Agent And Use For?


    topinchem.com
    https://www.topinchem.com › what-is-flavor-ws-23-cooli...
    topinchem.com
    https://www.topinchem.com › what-is-flavor-ws-23-cooli...
    Jun 2, 2023 — It is a white crystalline powder that has a cooling effect similar to menthol but without the associated taste or odor. WS-23 is considered to ...Read more

    The role of synthetic coolants, WS-3 and WS-23, in ...


    ScienceDirect.com
    https://www.sciencedirect.com › science › article › pii
    ScienceDirect.com
    https://www.sciencedirect.com › science › article › pii
    by S Yogeswaran · 2022 · Cited by 20 — Synthetic cooling agents (WS-23 and WS-3) provide a cooling sensation. Coolants in e-cigarettes modify acellular and ROS levels in lung epithelial cells.Read more
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