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    An AI Overview is not available for this searchCan't generate an AI overview right now. Try again later.
    AI Overview
    Pitavastatin calcium is a statin medication used to treat high cholesterol, often produced via intermediate compounds such as the (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid (+)-phenylethylamine salt. This key intermediate is a white powder used to synthesize the final active pharmaceutical ingredient, commonly identified by CAS number 147511-70-4. 
    Key intermediates for Pitavastatin often focus on the quinoline core or the chiral side chain required for its mechanism as an HMG-CoA reductase inhibitor. 
    Common Intermediate Details 
    • Name: (3R,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid (+)-phenylethylamine salt
    • CAS Number: 147511-70-4
    • Formula:
      𝐶25
      𝐻26
      𝐹𝑁𝑂4
      ⋅𝐶8𝐻11
      𝑁
    • Purity Standard: Typically >99% (HPLC)
    • Appearance: White powder 
    Uses in Production
    These intermediates are used in the synthesis of Pitavastatin calcium, which is a synthetic statin designed to inhibit the enzyme that produces cholesterol in the liver. It is used to reduce LDL-C and triglycerides in adults and children 8 years and older. 
    Key Considerations 
    • Drug Function: Pitavastatin calcium acts as a moderate-intensity statin, often used in 2mg-4mg doses.
    • Supply: Supplied by various pharmaceutical ingredient manufacturers, such as Sinoway, as a key step toward the final API.
    • Reactions: Used in the creation of the final HMG-CoA reductase inhibitor, a class of drugs that lowers cholesterol. 
    • Livalo (pitavastatin): Uses, Side Effects, Dosage & More
      Pitavastatin calcium, also known by its brand name, Livalo, is a moderate-intensity statin for people with high cholesterol. It lo...
      GoodRx
    • Pitavastatin calcium intermediate 147511-70-4 - Sinoway
      Pitavastatin calcium intermediate (3R,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid (+)-
      www.china-sinoway.com
    • Openbaar beoordelingsrapport
      May 14, 2024 — The active substance is pitavastatin calcium, an established active substance not described in the European Pharmacopoeia but in t...
      Geneesmiddeleninformatiebank
    • Pitavastatin calcium - DrugBank
      Pitavastatin, also known as the brand name product Livalo, is a lipid-lowering drug belonging to the statin class of medications. ...
      DrugBank
    • Process for preparing pitavastatin, intermediates and ...
      Wherein n=1, M is H +, Na +, K + n=2, M is Mg +2, Ca +2. Pitavastatin is a synthetic lipid-lowering agent that acts as an inhibito...
      Google Patents
    • Label: PITAVASTATIN CALCIUM tablet - DailyMed
      Mar 20, 2024 — Pitavastatin is indicated as an adjunct to diet to reduce low-density lipoprotein cholesterol (LDL-C) in: Adults with primary hype...
      DailyMed (.gov)
    • Pitavastatin Uses, Side Effects & Warnings - Drugs.com
      May 6, 2024 — What is pitavastatin? Pitavastatin is used in adults together with diet to lower blood levels of "bad" cholesterol (low-density li...
      Drugs.com
    • Pitavastatin - StatPearls - NCBI Bookshelf - NIH
      Jul 4, 2023 — Pitavastatin is a moderate-intensity statin. The dose range for pitavastatin is between 1 mg to 4 mg once daily; 2 mg once daily i...
      National Institutes of Health (.gov)
    • Asian Descent | Zypitamag® (pitavastatin) tablets
      About Zypitamag * ZYPITAMAG is indicated as an adjunctive therapy to diet in adult patients with primary hyperlipidemia or mixed d...
      www.zypitamag.com
    • Livalo (pitavastatin): Uses, Side Effects, Dosage & More
      Pitavastatin calcium, also known by its brand name, Livalo, is a moderate-intensity statin for people with high cholesterol. It lo...
      GoodRx
    • Pitavastatin calcium intermediate 147511-70-4 - Sinoway
      Pitavastatin calcium intermediate (3R,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid (+)-
      www.china-sinoway.com
    • Openbaar beoordelingsrapport
      May 14, 2024 — The active substance is pitavastatin calcium, an established active substance not described in the European Pharmacopoeia but in t...
      Geneesmiddeleninformatiebank
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    Web results

    Livalo (pitavastatin): Uses, Side Effects, Dosage & More


    GoodRx
    https://www.goodrx.com › livalo › what-is
    GoodRx
    https://www.goodrx.com › livalo › what-is
    Pitavastatin calcium, also known by its brand name, Livalo, is a moderate-intensity statin for people with high cholesterol. It lowers "bad" cholesterol and ...Read more

    Pitavastatin (oral route) - Side effects & dosage


    Mayo Clinic
    https://www.mayoclinic.org › description › drg-20073137
    Mayo Clinic
    https://www.mayoclinic.org › description › drg-20073137
    Feb 1, 2026 — Description. Pitavastatin is used together with a proper diet to lower high cholesterol levels and triglyceride (fat) levels in the blood ...Read more

    Label: PITAVASTATIN CALCIUM tablet - DailyMed


    DailyMed (.gov)
    https://dailymed.nlm.nih.gov › dailymed › lookup
    DailyMed (.gov)
    https://dailymed.nlm.nih.gov › dailymed › lookup
    Pitavastatin is indicated as an adjunct to diet to reduce low-density lipoprotein cholesterol (LDL-C) in: Adults with primary hyperlipidemia. Adults and ...Read more
    Missing: intermediate ‎| Show results with: intermediate

    Pitavastatin calcium


    DrugBank
    https://go.drugbank.com › salts › DBSALT000140
    DrugBank
    https://go.drugbank.com › salts › DBSALT000140
    Pitavastatin, also known as the brand name product Livalo, is a lipid-lowering drug belonging to the statin class of medications.Read more
    Missing: intermediate ‎| Show results with: intermediate

    Process for preparing pitavastatin, intermediates and ...


    Google Patents
    https://patents.google.com › patent
    Google Patents
    https://patents.google.com › patent
    The present invention relates to an improved process for the preparation of pitavastatin and its pharmaceutically acceptable salts, compounds of general formula ...Read more
    Pitavastatin calcium intermediate from patents.google.com

    Pitavastatin calcium intermediate 147511-70-4 - Sinoway


    china-sinoway.com
    https://www.china-sinoway.com › pitavastatin-calcium-i...
    china-sinoway.com
    https://www.china-sinoway.com › pitavastatin-calcium-i...
    Pitavastatin calcium intermediate 147511-70-4 ; CAS No. 147511-70-4 ; Molecular Formula. C2 H7 N ; Molecular Weight. 45.0837 ; Quality Standard. 99% up by HPLC.Read more
    Pitavastatin calcium intermediate from www.china-sinoway.com

    Pitavastatin - StatPearls - NCBI Bookshelf - NIH


    National Institutes of Health (.gov)
    https://www.ncbi.nlm.nih.gov › books › NBK557402
    National Institutes of Health (.gov)
    https://www.ncbi.nlm.nih.gov › books › NBK557402
    by H Bhatti · 2023 · Cited by 7 — Pitavastatin is a medication used in the management and treatment of hypercholesterolemia and dyslipidemia. It is in the statin class of drugs.Read more

    Pitavastatin Calcium: Clinical Review of a New ...


    ScienceDirect.com
    https://www.sciencedirect.com › article › abs › pii
    ScienceDirect.com
    https://www.sciencedirect.com › article › abs › pii
    by LL Yee · 2011 · Cited by 26 — Overall, the effect of pitavastatin on cholesterol was comparable to those of atorvastatin and simvastatin at low to intermediate doses. Studies on the ...Read more

    CAS 1159588-21-2 ((Z)-Pitavastatin Calcium Salt)


    BOC Sciences
    https://www.bocsci.com › ... › Pitavastatin and Impurities
    BOC Sciences
    https://www.bocsci.com › ... › Pitavastatin and Impurities
    (Z)-Pitavastatin Calcium Salt is a synthetic statin compound designed to lower cholesterol levels by selectively inhibiting the enzyme HMG-CoA reductase.Read more
    Pitavastatin calcium intermediate from www.bocsci.com
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    Does pitavastatin contain calcium?
    Pitavastatin (usually as a calcium salt) is a member of the blood cholesterol lowering medication class of statins. Pitavastatin is an inhibitor of HMG-CoA reductase, the enzyme that catalyses the first step of cholesterol synthesis.

    Pitavastatin - Wikipedia


    Wikipedia
    https://en.wikipedia.org › wiki › Pitavastatin
    Wikipedia
    https://en.wikipedia.org › wiki › Pitavastatin
    Does pitavastatin cause weight gain?
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    Web results

    Pitavastatin calcium: uses, dosing, warnings, adverse ...


    MedCentral
    https://www.medcentral.com › drugs › monograph › pit...
    MedCentral
    https://www.medcentral.com › drugs › monograph › pit...
    Pitavastatin is used as an adjunct to diet to decrease low-density lipoprotein (LDL)-cholesterol in adults with primary hyperlipidemia.Read more
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