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    AI Overview
    WS-3 (
    Ncap N
    𝑁
    -Ethyl-
    pp
    𝑝
    -menthane-3-carboxamide, CAS 39711-79-0) is a high-purity, synthetic cooling agent known for its clean, immediate, and long-lasting cooling sensation, particularly at the back of the mouth and tongue, with a milder, less bitter minty taste compared to other agents. It is widely used in food, beverages, personal care products, and oral care as a stronger alternative to menthol. 
    Key Aspects of WS-3 Cooling Agent: 
    • Performance: WS-3 offers a high cooling strength, roughly 1.5 times stronger than menthol (rated ~150 vs. 100).
    • Usage Areas:
      • Food & Beverage: Chewing gum, candies, mints, and beverages (0.5%–1.5% dosage range).
      • Personal Care & Cosmetics: Toothpaste, mouthwash, lotions, and creams.
      • Others: Nicotine products and tobacco replacements.
    • Characteristics: It provides a strong, quick-acting, and long-lasting cooling effect without the sharp, pungent aroma of menthol.
    • Formulation: It is stable in a pH range of 3–8 and should be stored away from high heat (>80°C).
    • Safety: Studies on the 90-day inhalation toxicity of WS-3 and related compounds like WS-23 showed no adverse clinical signs at typical usage levels. 
    WS-3 is sometimes used alongside other agents like WS-23 to provide a comprehensive, lingering, and intense cooling effect. 
    • The role of synthetic coolants, WS-3 and WS-23, in modulating E ...
      One study had found, via GC-MS and LC-HRMS/MS, that both WS-3 and WS-23 were major components found in nicotine-containing vaping ...
      ScienceDirect.com
    • WS-3 N-ethyl 2-isopropyl-5-methylcyclohexanecarboxamide
      N-ethyl 2-isopropyl-5-methylcyclohexanecarboxamide.
      The Good Scents Company
    • Sales of cigarettes with WS-3, a synthetic cooling agent, in an area ...
      Abstract. Introduction: The synthetic cooling agent WS-3 (N-ethyl-p-menthane-3-carboxamide) elicits a cooling sensation without a ...
      National Institutes of Health (.gov)
    • Evaluation of synthetic cooling agents WS-3 and WS-23 in 90-day ...
      WS-3 and WS-23 showed no adverse clinical signs at the levels studied. Dose-related pulmonary and systemic exposures were demonstr...
      CORESTA
    • WS-3 Cooling Agent: Applications,Benefits,and ...
      1) Food and Beverage Industry. Chewing Gum/Mints: Amplifies the "fresh breath" effect with rapid cooling. Energy Drinks: Adds a cr...
      Anhui Chinaherb Flavors&Fragrances Co.,Ltd.
    • Factory Supply wholesale food additive ws3 cooling agent ws-3
      Differences of the WS series cooling agent ... With mint aroma, it can burst in the month, strong impact on the month. ... It occu...
      www.zoranchem.com
    • (PDF) Two Techniques for the Analysis of WS-3 With Potential Application to the Analysis of Other Cooling Agents *
      Abstract and Figures Le WS-3 (N-éthyl- -m enthane-3-carboxamide) est un com- mide), l'Evercool 180 (N- -benzène-acétonitrile menth...
      ResearchGate
    • Evaluation of synthetic cooling agents, WS-3 and WS-23, in 90-day inhalation toxicity studies in Sprague Dawley rats
      Cooling agents WS-3 and WS23 are TRPM8 receptor agonists providing an intensive and lingering cooling trigeminal effect. Widely us...
      CORESTA
    • The role of synthetic coolants, WS-3 and WS-23, in modulating E ...
      One study had found, via GC-MS and LC-HRMS/MS, that both WS-3 and WS-23 were major components found in nicotine-containing vaping ...
      ScienceDirect.com
    • WS-3 N-ethyl 2-isopropyl-5-methylcyclohexanecarboxamide
      N-ethyl 2-isopropyl-5-methylcyclohexanecarboxamide.
      The Good Scents Company
    • Sales of cigarettes with WS-3, a synthetic cooling agent, in an area ...
      Abstract. Introduction: The synthetic cooling agent WS-3 (N-ethyl-p-menthane-3-carboxamide) elicits a cooling sensation without a ...
      National Institutes of Health (.gov)
    Show all
    • thegoodscentscompany.com
    • cnherbflavor.com
    • zoranchem.com
    • pubmed.ncbi.nlm.nih.gov
    • sciencedirect.com
    • coresta.org
    • researchgate.net
    • coresta.org
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    Web results

    WS 3 | CAS 39711-79-0 | WS3


    Tocris Bioscience
    https://www.tocris.com › ... › TRPM Channel Agonists
    Tocris Bioscience
    https://www.tocris.com › ... › TRPM Channel Agonists
    Discontinued Product ; Description: TRPM8 agonist; cooling agent ; Chemical Name: N-Ethyl-5-methyl-2-(1-methylethyl)cyclohexanecarboxamide ; Purity: ≥99% (HPLC).Read more
    $45 delivery
    People also ask
    What is WS-3 cooling agent?
    An error has occurred. Please try again later.
    Is WS-3 safe?
    Conclusions. Synthetic cooling agents (WS-3/WS-23) were present in US-marketed E-cigarettes, at levels that may result in consumer exposures exceeding safety thresholds set by regulatory agencies.

    Synthetic Cooling Agents in US-marketed E-cigarette Refill ...


    PMC - NIH
    https://pmc.ncbi.nlm.nih.gov › articles › PMC9199944
    PMC - NIH
    https://pmc.ncbi.nlm.nih.gov › articles › PMC9199944
    What is the most used cooling agent?
    Common cooling agents include water, salt water, ethan glycol aqueous solution, heat conduction oil, etc.

    What are the commonly used coolant? - ECHEMI


    Echemi
    https://www.echemi.com › community › what-are-the-co...
    Echemi
    https://www.echemi.com › community › what-are-the-co...
    Is koolada ws-3?
    Cooling agent WS-3 (as known as Koolada 3, N-Ethyl-p-menthane-3-carboxamide) is a synthetic compound used to provide a cooling sensation in various consumer products. It offers a cooling effect of 1.5 and lasts up to 6 minutes.

    Cooling Agents WS-3 - Foreverest Resources Ltd


    Foreverest Resources
    https://foreverest.net › products › other-specialty-chemicals
    Foreverest Resources
    https://foreverest.net › products › other-specialty-chemicals

    Web results

    The role of synthetic coolants, WS-3 and WS-23, in ...


    ScienceDirect.com
    https://www.sciencedirect.com › science › article › pii
    ScienceDirect.com
    https://www.sciencedirect.com › science › article › pii
    by S Yogeswaran · 2022 · Cited by 20 — Synthetic cooling agents (WS-23 and WS-3) provide a cooling sensation. Coolants in e-cigarettes modify acellular and ROS levels in lung epithelial cells.Read more

    Symcool® Cooling Agents


    Symrise
    https://www.symrise.com › Aroma_molecules › sy...
    Symrise
    https://www.symrise.com › Aroma_molecules › sy...
    PDF
    WS-3 is one of the most used cooling agents in the market and it's known for its clean immediate cooling impact and has been found to cool primarily at the roof ...Read more
    6 pages
    Discussions and forums
    Can someone recommend a cooling Agent?
    Reddit · 
    r/DIY_eJuice
     · 30+ comments
     · 5 years ago
    Can someone recommend a cooling Agent?
    Reddit · 
    r/DIY_eJuice
     · 30+ comments
     · 5 years ago
    WS-23 doesn't have a menthol taste to it and only provides the medium to strong cooling effect. WS-3, which is also known as koolada, has a ...  More
    In light of the few post asking about menthol and other cooling agents
    Reddit · 
    r/DIY_eJuice
     · 20+ comments
     · 9 years ago
    In light of the few post asking about menthol and other cooling agents
    Reddit · 
    r/DIY_eJuice
     · 20+ comments
     · 9 years ago
    I have come across a rather interesting article about cooling agents. TL:DR. Koolada (cooling agent WS 3) and Cooling agent WS 23 ( the one ...  More
    Drip Hacks Koolada ws23, Koolada WS3 or Koolada WS5 Crystals?
    Vaping Forum · 
    8 years ago
    Drip Hacks Koolada ws23, Koolada WS3 or Koolada WS5 Crystals?
    Vaping Forum · 
    8 years ago
    I've heard of people mixing Drip Hacks Koolada WS-23 along WS ... Wilkinson sword patents for cooling agent for toothpaste, mouthwash etc.  More
    See more

    Web results

    WS-3 N-ethyl 2-isopropyl-5-methylcyclohexanecarboxamide


    The Good Scents Company
    https://www.thegoodscentscompany.com › data
    The Good Scents Company
    https://www.thegoodscentscompany.com › data
    Odor Type: minty. Odor Strength:low. mentholic minty alcoholic cooling. Odor Description:at 25.00 % in dipropylene glycol. mild mentholic mintyRead more

    WS-3 Cooling Agent: Applications,Benefits,and ...


    Anhui Chinaherb Flavors&Fragrances Co.,Ltd.
    https://www.cnherbflavor.com › blog › ws-3-cooling-ag...
    Anhui Chinaherb Flavors&Fragrances Co.,Ltd.
    https://www.cnherbflavor.com › blog › ws-3-cooling-ag...
    May 9, 2025 — WS-3 is a synthetic cooling compound developed to provide a stronger cooling impact than traditional menthol. Its mechanism involves activating ...Read more

    Menthol Carboxamide (WS-3)


    MarkNature
    https://marknature.com › products › menthol-carboxam...
    MarkNature
    https://marknature.com › products › menthol-carboxam...
    Menthol Carboxamide (WS-3), a pioneering compound with a chemical formula C13H25NO, delivering a distinct cooling sensation, separate from menthol.
    $98.00 to $787.00 · In stock · $245.40 delivery · 30-day returns

    WS 3 (COOLING AGENT)


    Prodasynth
    https://prodasynth.com › ...
    Prodasynth
    https://prodasynth.com › ...
    PDF
    Provide adequate ventilation, according to the conditions of use. Use a mechanical exhaust if required. WS 3 (COOLING AGENT). 07-04-2026 ...Read more

    Evaluation of synthetic cooling agents WS-3 and WS-23 in ...


    CORESTA
    https://www.coresta.org › abstracts › evaluation-synthetic...
    CORESTA
    https://www.coresta.org › abstracts › evaluation-synthetic...
    Here, we discuss the toxicological effects via inhalation of WS-3 and WS-23 in separate 90-day nose-only inhalation toxicity studies in rats.Read more
    Popular products
    • WS-3 Cooling Agent.
      WS-3 Cooling Agent
      $50.00
      topfoodchemicals.com
      WS-3 Cooling Agent
      $50.00
      topfoodchemicals.com
    • Koolada Solution (WS-3) 120ml.
      Koolada Solution (WS-3) 120ml
      $16.99
      FlavorJungle
      Koolada Solution (WS-3) 120ml
      $16.99
      FlavorJungle
    • Menthol Carboxamide(WS-3) 1 lb (454 g).
      Menthol Carboxamide(WS-3) 1 lb (454 g)
      $148.00
      Fingredients
      Menthol Carboxamide(WS-3) 1 lb (454 g)
      $148.00
      Fingredients
    • Menthol Carboxamide WS-3 Innovative Cooling Sensation Compound.
      Menthol Carboxamide WS-3 Innovative Cooling Sensation Compound
      $98.00
      MarkNature
      Menthol Carboxamide WS-3 Innovative Cooling Sensation Compound
      $98.00
      MarkNature

    Web results

    WS3


    Anshul Specialty Molecules Private Limited
    https://www.anshulchemicals.com › ws3
    Anshul Specialty Molecules Private Limited
    https://www.anshulchemicals.com › ws3
    It delivers a revitalizing and soothing cooling sensation that invigorates the skin, making it ideal for premium skincare formulations. What sets WS3 apart is ...Read more
    People also search for
    WS-3 cooling agent side effects
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