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2-arm Methoxypoly(ethylene glycol) succinimidyl ester (2-arm mPEG-NHS) is an activated, branched PEG derivative used for pegylation, typically reacting with primary amines to form stable amide linkages. It is often used to modify proteins, peptides, or nanoparticles to improve stability and reduce immunogenicity. Common forms include 2-arm PEG-SCM or 2-arm PEG-SS, frequently available in molecular weights of 5kDa to 40kDa.

Structure: Two methoxy-PEG chains attached to a central core, terminating in a reactive N-hydroxysuccinimide (NHS) ester.
Reactivity: The succinimidyl ester is highly reactive toward amine groups (
$negative NH sub 2$
) at physiological or slightly alkaline pH (
).
Applications: Used for pharmaceutical development, drug delivery systems, and medical device coating to enhance drug solubility and circulation time.
Storage: Requires long-term storage at
$negative 20 raised to the composed with power C$
, desiccated, and protected from light.
Common Variants: 2-arm PEG-NHS (e.g., LYS01) and 2-arm PEG-SCM (Succinimidyl Carboxymethyl Ester).

Methoxy PEG Succinimidyl Succinamide - JenKem
JenKem Technology offers Methoxy PEG SSA with MW 5000 Da (M-SSA-5000), and MW 20000 Da (M-SSA-20K), in 1g and 10g packing sizes. D...
JenKem Technology USA
List of PEG Derivatives Application - Biopharma PEG
mPEG-SS, mPEG-Succinimidyl Succinate ester - Biopharma PEG
mPEG-Succinimidyl Succinate ester (mPEG-SS) is a type of mPEG-NHS ester reagent. It has a C2 aliphatic ester linkage between PEG a...
Biopharma PEG

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2-arm Methoxypoly(ethylene glycol) succinimidyl ester ...

Amerigo Scientific

https://www.amerigoscientific.com › 2-arm-methoxypol...

Amerigo Scientific

https://www.amerigoscientific.com › 2-arm-methoxypol...

2-arm Methoxypoly(ethylene glycol) succinimidyl ester(LYS01) , 2-arm PEG-NHS(LYS01) , 40kDa ; Catalog Number: PG01418555SIN ; Mfr. No.: 06020404415 ; Price: $324.Read more

2 Arm Methoxypoly Ethylene Glycol Succinimidyl Ester

SINOPEG

https://www.sinopeg.com › 2-arm-methoxypoly-ethyle...

SINOPEG

https://www.sinopeg.com › 2-arm-methoxypoly-ethyle...

2-arm Methoxypoly(ethylene glycol) succinimidyl carboxymethyl ester(PT02). Molecular Weight: 5KDa, 10KDa, 20KDa, 40KDa. Package Size: 1g/bottle, 10g/bottle, ...Read more

2-arm Methoxypoly(ethylene glycol) succinimidyl ...

Labshake

https://labshake.com › product ›

Labshake

https://labshake.com › product ›

2-arm Methoxypoly(ethylene glycol) succinimidyl carboxymethyl ester(PT02) [2-arm PEG-SCM(PT02)] ; Alfa Chemistry · VL-PD00016 · Inquire · 5KDa, 10KDa, 20KDa, 40KDa.Read more

List of PEG Derivatives Application

Biopharma PEG

https://www.biochempeg.com › article

Biopharma PEG

https://www.biochempeg.com › article

Jan 9, 2020 — The article shows the range of applications of PEGs in the medical device, drug development, and diagnostics areas, including drug delivery, ...

Missing: 2- ‎| Show results with: 2-

mPEG-SS - CD Bioparticles

cd-bioparticles.net

https://www.cd-bioparticles.net › mpeg-ss

cd-bioparticles.net

https://www.cd-bioparticles.net › mpeg-ss

CD Bioparticles provides Methoxy poly(ethylene glycol)-Succinimidyl Succinate with a PEG molecular weight of 2000 Da for drug delivery.

In stock$80 delivery

Methoxypoly Ethylene Glycol Succinimidyl Carboxymethyl ...

SINOPEG

https://www.sinopeg.com › blog › methoxypoly-ethyle...

SINOPEG

https://www.sinopeg.com › blog › methoxypoly-ethyle...

Apr 9, 2025 — mPEG-NCO (Methoxy Polyethylene Glycol Isocyanate) is a polyethylene glycol (PEG) derivative with an isocyanate (-NCO) active group at the ...Read more

4-Arm PEG-SS (SS: Succinimidyl Succinate)

Creative PEGWorks

https://creativepegworks.com › Products

Creative PEGWorks

https://creativepegworks.com › Products

4-Arm PEG-SS is succinimidyl NHS ester groups at each terminal of the four arms. PEG-SS (succinimidyl succinate ester) is one type of PEG-NHS reagents.

Methoxypolyethylene glycol succinimidyl ester, mPEG-NHS

Nanocs

https://www.nanocs.net › document › DataSheet

Nanocs

https://www.nanocs.net › document › DataSheet

PDF

N-hydroxylsuccinimide (NHS) functionalized methoxy polyethylene glycol (mPEG-NHS) is an amine (-NH2) reactive PEG derivative that can be used to modify proteins ...Read more

1 page

Methoxy poly(ethylene glycol) succinimidyl valerate (mPEG ...

Gannet BioChem

https://laysanbio.com › mPEG-SVA_final_review

Gannet BioChem

https://laysanbio.com › mPEG-SVA_final_review

PDF

The succinimidyl valerate is an active ester used for the PEGylation of primary amines. The reaction of the SVA with an amine forms a stable amide linkage.Read more

1 page

Web results

Methoxy PEGs for PEGylation - JenKem Technology

JenKem Technology USA

https://jenkemusa.com › methoxy-pegs-for-pegylation

JenKem Technology USA

https://jenkemusa.com › methoxy-pegs-for-pegylation

Mar 25, 2026 — Methoxy PEG Succinimidyl Glutarate is a degradable PEG linker that reacts with the amino group of lysine(s) on proteins or other biologics at pH ...Read more

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2-arm Methoxypoly(ethylene glycol) succinimidyl ester ...

2 Arm Methoxypoly Ethylene Glycol Succinimidyl Ester

2-arm Methoxypoly(ethylene glycol) succinimidyl ...

List of PEG Derivatives Application

mPEG-SS - CD Bioparticles

Methoxypoly Ethylene Glycol Succinimidyl Carboxymethyl ...

4-Arm PEG-SS (SS: Succinimidyl Succinate)

Methoxypolyethylene glycol succinimidyl ester, mPEG-NHS

Methoxy poly(ethylene glycol) succinimidyl valerate (mPEG ...

Methoxypolyethylene glycol succinimidyl succinate

A Guide to Polyethylene Glycol (PEG) - Green Seal

What Are U.S. Regulations and Guidelines for Ethylene Glycol ...

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Methoxy PEGs for PEGylation - JenKem Technology

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