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    AI Overview
    R421A Refrigerant 25lb Cylinder Tank - Reliable HVAC ...
    R421A is a high-performance, non-ozone depleting HFC blend (R125/R134a) designed as a direct "drop-in" replacement for R22 in residential/commercial A/C and medium/high-temperature refrigeration. It offers superior compatibility with existing mineral, AB, or POE oils, requires no unit modifications, and features zero ozone depletion potential (ODP). 
    Key Features and Benefits 
    • Performance: Provides capacity and efficiency similar to R22, with pressure-temperature values almost identical.
    • Compatibility: Compatible with Mineral (MO), Alkylbenzene (AB), and Polyol Ester (POE) oils.
    • "Drop-in" Solution: No oil change or hardware modifications are required in most cases.
    • Environmental: Non-ozone depleting (ODP=0) with a global warming potential (GWP) of approximately 2200.
    • Safety: Rated A1 (non-flammable) by ASHRAE.
    • No Hydrocarbons: Does not contain butane or propane components. 
    Common Applications 
    • Residential/commercial air conditioning (split systems, packaged units).
    • Medium and high-temperature commercial/industrial refrigeration.
    • Ideal for retrofit scenarios where full system replacement is not feasible. 
    Usage Guidelines 
    • Charging: Must be charged as a liquid with the cylinder inverted, preferably using a scale to match the original R22 charge weight.
    • Topping Off: Because it is a two-component binary blend with a very small fractionation rate (0.3 of a degree), it can be topped off after leaks.
    • Restrictions: Requires EPA Section 608 certification to purchase. 
    Technical Data 
    • Composition: R125 (58%) / R134a (42%).
    • Classification: HFC Blend (Zeotropic).
    • Packaging: Typically sold in 25 lb cylinders. 
    It is important to note that while R421A mimics R22 well, it may not improve performance in already damaged or underperforming systems. 
    • Choice™ R421A Refrigerant
      Choice™ R421A is a non-ozone depleting refrigerant that can be used in a variety of applications. It can be used in: * Air conditi...
      A-Gas
    • Shearer Stock - Refrigerant, R421A, 25 lbs
      Features * Unique non-ozone depleting, long-term replacement for R22 refrigerant. * Environmentally GREEN refrigerant. * Replace R...
      Shearer Supply
    • Part 7, Pros and Cons of R-421A & Conclusion
      Sep 28, 2017 — welcome to another edition of Chadwell. University working through the maze of refrigerants. and the different choices. that are o...
      10m
      YouTube·Chadwell Supply
    Show all
    • Choice™ R421A Refrigerant
      Choice™ R421A is a non-ozone depleting refrigerant that can be used in a variety of applications. It can be used in: * Air conditi...
      A-Gas
    • Shearer Stock - Refrigerant, R421A, 25 lbs
      Features * Unique non-ozone depleting, long-term replacement for R22 refrigerant. * Environmentally GREEN refrigerant. * Replace R...
      Shearer Supply
    • Part 7, Pros and Cons of R-421A & Conclusion
      Sep 28, 2017 — welcome to another edition of Chadwell. University working through the maze of refrigerants. and the different choices. that are o...
      10m
      YouTube·Chadwell Supply
    • R421A Refrigerant 25lb Cylinder Tank - Reliable HVAC ...
      Description. R421A is a hydrofluorocarbon (HFC) refrigerant blend used as a direct replacement for R22 in air conditioning and ref...
      Jackson Systems
    • R421A Refrigerant - Johnstone Supply
      R22 alternative non-ozone depleting 2 component blend refrigerant · Replace R22 without unit modification in most cases · Compatib...
      Johnstone Supply
    • HVAC Choice Refrigerants R-421A Field Use
      Feb 10, 2017 — Charge R421A as a liquid with the bottle inverted. Use a scale to weigh in the exact amount specified on the unit nameplate.
      11:48
      YouTube·CochiseCounty_Travels
    • R421A 25 lbs cylinders | JJ AC SUPPLY
      Refrigerant R421A is a unique non-ozone depleting replacement for R22. Usable with Mineral, AB, or POE oils, this refrigerant can ...
      jj ac supply
    • Refrigerant 421A Specialty Gas size 30 lb Disposable - Arc3 Gases
      Refrigerant 421A (R-421A) is a non-ozone depleting, HFC-based blend designed as a direct, eco-friendly, "drop-in" replacement for ...
      Arc3 Gases
    • R-421A Wholesale Price 2026 - Alper Refrigerant Gas
      ⚠️ PROFESSIONAL USE ONLY. EPA Section 608 certification REQUIRED for purchase. This product is regulated under the Clean Air Act a...
      Alper Refrigerants
    • The Ultimate Guide to R-421A Refrigerant - eRefrigerants.com
      R-421A refrigerant is commonly used in a variety of applications, including residential air conditioning units, commercial refrige...
      eRefrigerants.com
    • Pure R421A Refrigerant Gas
      R421A is a high-performance R22 replacement refrigerant renowned for its eco-friendly properties and strong system compatibility, ...
      www.taninrefrigerant.com
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    Web results

    Choice™ R421A Refrigerant


    A-Gas
    https://www.agas.com › refrigerant-products › r421a
    A-Gas
    https://www.agas.com › refrigerant-products › r421a
    Choice™ R421A refrigerant is a unique non-ozone depleting replacement for R22. Its performance temperature ranges are also comparable with those of R22.
    Missing: Purity ‎| Show results with: Purity

    R421A Refrigerant


    Johnstone Supply
    https://www.johnstonesupply.com › product-view
    Johnstone Supply
    https://www.johnstonesupply.com › product-view
    R22 alternative non-ozone depleting 2 component blend refrigerant · Replace R22 without unit modification in most cases · Compatible with Mineral, AB or POE oils ...Read more
    60-day returns
    Missing: Purity ‎| Show results with: Purity

    R421A 25lb Refrigerant - R22 alternative non-ozone


    Refrigerants Center, inc
    https://refrigerantscenter.com › Collections › all
    Refrigerants Center, inc
    https://refrigerantscenter.com › Collections › all
    This refrigerant is commonly used for air conditioning maintenance, system retrofits, and routine servicing where full system replacement is not an option. Buy ...Read more
    $350.00 · Out of stock · 5.0(2)
    Missing: Purity ‎gas

    R-421A Refrigerant 25 lb.


    eRefrigerants.com
    https://erefrigerants.com › products › r-421a-refrigerant-...
    eRefrigerants.com
    https://erefrigerants.com › products › r-421a-refrigerant-...
    Refrigerant R421A is a unique non-ozone depleting replacement for R22. Usable with Mineral, AB, or POE oils, this refrigerant can be used in air conditioning.Read more
    $409.00 to $6,780.00 · In stock · 5.0(8) · Free delivery · 30-day returns

    Pure R421A Refrigerant Gas


    taninrefrigerant.com
    https://www.taninrefrigerant.com › Refrigerant
    taninrefrigerant.com
    https://www.taninrefrigerant.com › Refrigerant
    R421A is a high-performance R22 replacement refrigerant renowned for its eco-friendly properties and strong system compatibility, making it a preferred choice ...Read more

    R22 Replacement Choice 421A


    Choice Refrigerants
    https://www.choicerefrigerants.com › choice-r421a
    Choice Refrigerants
    https://www.choicerefrigerants.com › choice-r421a
    Available in 12lb and 25lb cylinders, Choice R-421A is designed to run in air-conditioning, and mid-to high-temp applications.Read more
    Missing: Purity ‎| Show results with: Purity

    R-421A Refrigerant 25 LB


    CoolmateGas
    https://coolmategas.com › products › r-421a-refrigerant...
    CoolmateGas
    https://coolmategas.com › products › r-421a-refrigerant...
    R421A is a hydrofluorocarbon (HFC) refrigerant blend that is designed as a replacement for R22 in various air conditioning and refrigeration applications.Read more
    $426.95 to $7,280.00 · In stock · 5.0(535) · Free delivery · 30-day returns
    Popular products
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    • R421A Choice Refrigerant.
      R421A Choice Refrigerant
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    • R421A Cylinder — Choice Refrigerants.
      R421A Cylinder — Choice Refrigerants
      $195.00
      Choice Refrigerants
      R421A Cylinder — Choice Refrigerants
      $195.00
      Choice Refrigerants
    • R421A Refrigerant 25 LB | Arctic Prince.
      R421A Refrigerant 25 LB | Arctic Prince
      $170.00
      deskcodes.io
      Free delivery
      R421A Refrigerant 25 LB | Arctic Prince
      $170.00
      deskcodes.io
      Free delivery
    • R-421A Refrigerant 25 LB| CoolmateGas Refrigerant.
      R-421A Refrigerant 25 LB| CoolmateGas Refrigerant
      $426.95
      CoolmateGas
      Free delivery by Fri
      R-421A Refrigerant 25 LB| CoolmateGas Refrigerant
      $426.95
      CoolmateGas
      Free delivery by Fri
    • R-421A Refrigerant 25 lb. 1 Cylinder.
      R-421A Refrigerant 25 lb. 1 Cylinder
      $409.00
      eRefrigerants.com
      Free delivery by Fri
      5.0(8)
      R-421A Refrigerant 25 lb. 1 Cylinder
      $409.00
      eRefrigerants.com
      Free delivery by Fri
      5.0(8)
    • R-421A Refrigerant 25 LB|CoolmateGas Refrigerant, 1 Cylinder.
      R-421A Refrigerant 25 LB|CoolmateGas Refrigerant, 1 Cylinder
      $426.95
      CoolmateGas
      Free delivery by Fri
      5.0(532)
      R-421A Refrigerant 25 LB|CoolmateGas Refrigerant, 1 Cylinder
      $426.95
      CoolmateGas
      Free delivery by Fri
      5.0(532)
    • R-421A Refrigerant R421A 25lb Replacement for R22 (BULK).
      R-421A Refrigerant R421A 25lb Replacement for R22 (BULK)
      $334.33
      Voomi Supply
      Free delivery by Thu
      4.0(1)
      R-421A Refrigerant R421A 25lb Replacement for R22 (BULK)
      $334.33
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    Web results

    HFC Refrigerants - R-421A


    Summit Refrigerants
    https://www.summitrefrigerants.com › refrigerant-...
    Summit Refrigerants
    https://www.summitrefrigerants.com › refrigerant-...
    PDF
    Summit Refrigerants is an EPA certified refrigerant reclaimer that provides the US HVACR industry with a broad range of fluorinated refrigerants to include ...Read more
    5 pages

    R421A Refrigerant Replacement - Shop Today


    Refrigerant Guys
    https://www.refrigerantguys.com › R421A-Choice-Refri...
    Refrigerant Guys
    https://www.refrigerantguys.com › R421A-Choice-Refri...
    R-421A is a drop-in replacement for R22 systems. With this refrigerant there is no need to change the oil. Simply recover the R22 and recharge with R421A.Read more
    $295.00 · In stock · 4.5 (6) · $41 delivery
    Missing: Purity ‎gas
    More products
    • R-421A Refrigerant 25 LB|CoolmateGas Refrigerant 20 Cylinders $364 each.
      R-421A Refrigerant 25 LB|CoolmateGas Refrigerant 20 Cylinders $364 each
      $7,280.00
      CoolmateGas
      Free delivery by Fri
      R-421A Refrigerant 25 LB|CoolmateGas Refrigerant 20 Cylinders $364 each
      $7,280.00
      CoolmateGas
      Free delivery by Fri
    • R-421A Refrigerant 25 lb. 10 Cylinders ($359 each).
      R-421A Refrigerant 25 lb. 10 Cylinders ($359 each)
      $3,590.00
      eRefrigerants.com
      Free delivery by Fri
      R-421A Refrigerant 25 lb. 10 Cylinders ($359 each)
      $3,590.00
      eRefrigerants.com
      Free delivery by Fri
    • R421A Refrigerant 25 LBS FULL PALLET (40 Cylinders).
      R421A Refrigerant 25 LBS FULL PALLET (40 Cylinders)
      $3,193.00
      deskcodes.io
      Free delivery
      R421A Refrigerant 25 LBS FULL PALLET (40 Cylinders)
      $3,193.00
      deskcodes.io
      Free delivery
    • R-421A Refrigerant 25 lb. 20 Cylinders ($339 each).
      R-421A Refrigerant 25 lb. 20 Cylinders ($339 each)
      $6,780.00
      eRefrigerants.com
      Free delivery by Fri
      5.0(8)
      R-421A Refrigerant 25 lb. 20 Cylinders ($339 each)
      $6,780.00
      eRefrigerants.com
      Free delivery by Fri
      5.0(8)

    Web results

    R421A FREON 25LB CYL REFRIGERANT


    DSG Supply
    https://www.dsgsupply.com › ...
    DSG Supply
    https://www.dsgsupply.com › ...
    R421A FREON 25LB CYL REFRIGERANT.
    People also ask
    Is R421A the same as R22?
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    Summarize key differences in a table
    Explain the R-22 phase-out in detail
    Tell me more about R-421A's composition
    How much is R421A per pound?
    Cost of Refrigerant per Pound
    RefrigerantCost per Pound (Materials Only)
    R421A$6 - $9
    NU-22$7 - $8
    R422B$7 - $9
    MO99$9 - $11
    8 more rows

    How much does it cost to recharge a home AC? - Fixr.com


    Fixr.com
    https://www.fixr.com › costs › home-ac-recharge
    Fixr.com
    https://www.fixr.com › costs › home-ac-recharge
    What is 421A compatible with?
    R-421A refrigerant is commonly used in a variety of applications, including residential air conditioning units, commercial refrigeration systems, and industrial cooling systems. It is suitable for both low and medium temperature refrigeration applications, making it a versatile option for a wide range of cooling needs.

    The Ultimate Guide to R-421A Refrigerant - eRefrigerants.com


    eRefrigerants.com
    https://erefrigerants.com › blogs › blog › the-ultimate-gu...
    eRefrigerants.com
    https://erefrigerants.com › blogs › blog › the-ultimate-gu...
    What AC gas is now illegal?
    Freon has been banned in the U.S. since 2020, but some homes still use Freon-based AC units. Here's what the ban means for these homeowners.Apr 14, 2026

    What You Need to Know About the Freon Ban - This Old House


    This Old House
    https://www.thisoldhouse.com › heating-cooling › freon-...
    This Old House
    https://www.thisoldhouse.com › heating-cooling › freon-...
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