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DCE and DGE are advanced, often complementary, magnetic resonance imaging (MRI) techniques used to study tissue characteristics, particularly for cancer detection, blood-brain barrier permeability, and metabolism.
- DCE-MRI (Dynamic Contrast-Enhanced): Measures vascular permeability and blood flow using conventional paramagnetic contrast agents (like Gadolinium-based agents).
- DGE-MRI (Dynamic Glucose-Enhanced): A newer, molecular imaging technique that uses D-glucose as a biodegradable contrast agent to visualize glucose uptake, often using Chemical Exchange Saturation Transfer (CEST).
Key Differences and Combined Use
- Contrast Source: DCE uses artificial Gadolinium; DGE uses natural glucose.
- Mechanism: DCE highlights vascular leakage (BBB breakdown); DGE highlights glucose uptake and metabolism.
- Performance: DGE has lower sensitivity than DCE, but DGE-based AUC (Area Under the Curve) maps have demonstrated contrast comparable to DCE, effectively delineating blood vessels and tumors.
- Clinical Significance: Both techniques provide quantitative information (e.g., ,) to distinguish tumors from normal brain tissue.
- Combined Use: "DCE-DGE" or "Dual-Echo Gradient-Echo" (DGE) techniques are sometimes used together in research (e.g., for rodent brain tumor studies) to analyze vascular parameters through dual imaging protocols.
Applications in Research
- Tumor Imaging: DGE MRI detects higher glucose uptake in malignant tumor areas compared to normal tissue.
- BBB Permeability: Both DGE and DCE are used to detect areas of increased blood-brain barrier (BBB) permeability.
- Radiation Assessment: Combined DCE/DGE studies assist in identifying areas affected by radiation therapy, specifically in peritumoral regions.
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Web results
Dynamic Glucose Enhanced (DGE) MRI for Combined ... - PMC
PubMed Central (PMC) (.gov)
https://pmc.ncbi.nlm.nih.gov › articles › PMC4715614
PubMed Central (PMC) (.gov)
https://pmc.ncbi.nlm.nih.gov › articles › PMC4715614
by X Xu2015Cited by 168 — DGE MRI is a feasible technique for studying brain tumor enhancement reflecting differences in tumor blood volume and permeability with respect to normal brain.Read more
People also ask
What is the DCE sequence?
Dynamic contrast enhancement (DCE) imaging is a valuable sequence of multiparametric magnetic resonance imaging (mpMRI). A DCE sequence enhances the vasculature and complements T2-weighted (T2W) and Diffusion-weighted imaging (DWI), allowing early detection of prostate cancer.Nov 15, 2024
Quantitative DCE Dynamics on Transformed MR Imaging ... - PMC
PMC - NIH
https://pmc.ncbi.nlm.nih.gov › articles › PMC11565616
PMC - NIH
https://pmc.ncbi.nlm.nih.gov › articles › PMC11565616
Web results
China OEM DCE/DGE Manufacturer,Factory Price ...
Hitronics
https://www.global-hitronics.com › dce-dge_sp
Hitronics
https://www.global-hitronics.com › dce-dge_sp
Hitronics is a best DCE/DGE supplier in China,we supply various high quality DCE/DGE for sale,and also give you endless design options. Contact us now!
Tissue response curve shape analysis of dynamic glucose ...
Wiley
https://analyticalsciencejournals.onlinelibrary.wiley.com › ...
Wiley
https://analyticalsciencejournals.onlinelibrary.wiley.com › ...
by A Seidemo2023Cited by 9 — In resemblance to dynamic contrast enhanced (DCE) MRI, DGE MRI can yield response curves in a tissue of interest1,14-16, but without the need for gadolinium ...Read more
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Deep learning-based assessment of tissue response curves ...
PubMed Central (PMC) (.gov)
https://pmc.ncbi.nlm.nih.gov › articles › PMC11978497
PubMed Central (PMC) (.gov)
https://pmc.ncbi.nlm.nih.gov › articles › PMC11978497
by A Seidemo2022 — Dynamic glucose-enhanced (DGE) MRI is used to study the signal intensity time course (tissue response curve) after D-glucose injection.
Coking Coal - DCE
大连商品交易所
http://www.dce.com.cn › dceg › channel › list
大连商品交易所
http://www.dce.com.cn › dceg › channel › list
Product, Coking Coal. Trading Unit, 60 MT/Lot. Price Quote Unit, CNY/MT. Minimum Tick Size, 0.5 CNY/MT. Daily Price Limit Range, 4% of last settlement price.Read more
(A) and (B) illustrate the first and second echo of the DCE- ...
ResearchGate
https://www.researchgate.net › figure › A-and-B-illustra...
ResearchGate
https://www.researchgate.net › figure › A-and-B-illustra...
(A) and (B) illustrate the first and second echo of the DCE-DGE for a slice of rat brain about 8 min after the tail vein administration of CA.Read more
China OEM DCE/DGE Manufacturer,Factory ...
海创光电
https://www.hi-tronics.com › dge_sp
海创光电
https://www.hi-tronics.com › dge_sp
Hitronics is a best DCE/DGE supplier in China,we supply various high quality DCE/DGE for sale,and also give you endless design options. Contact us now!
Ronnie Wirestam - Medicinsk strålningsfysik, Lund
Medicinsk strålningsfysik, Lund
https://www.msf.lu.se › ronnie-wirestam › publication
Medicinsk strålningsfysik, Lund
https://www.msf.lu.se › ronnie-wirestam › publication
Summary, in English. Dynamic glucose enhanced (DGE) MRI is used to study the signal intensity time course (tissue response curve) after D-glucose injection. D ...Read more
Use of Quantitative DCE
Questions and Answers in MRI
https://mriquestions.com › utility-of-dce
Questions and Answers in MRI
https://mriquestions.com › utility-of-dce
For similar reasons, DCE parameters hold promise to distinguish progression from pseudoprogression and recurrent tumor vs radionecrosis. Two of our cases ...Read more