Cyclopamine is a Hedgehog (Hh) pathway antagonist . Cyclopamine suppresses cell growth. Cyclopamine (3 μM) suppression of Hh pathway activity and growth in ...

by F Hamon · 2010 · Cited by 28 — The carbamoyl derivatisation of cyclopamine significantly decreased its toxicity towards the U87 human glioblastoma cell line. However, when the prodrug was ...

by YJ Liu · 2017 · Cited by 31 — In the process of solid tumor treated by chemotherapy, drugs need to be able to permeate and accumulate deep into the tumor to kill cancer cells ...

Jul 19, 2017 — Cyclopamine, an inhibitor of the SMO oncogenic protein , and GLI1 siRNA were used as inhibitory agents of the Shh pathway in the two cell lines.

This preprint research paper has not been peer reviewed. Electronic copy available at: https://ssrn.com/abstract=4283380. Preprint not peer reviewed. Page 2. 2.

In the present study , a direct correlation was made between the extraction efficiency for cyclopamine from root and rhizome by eight methods, and the associated ...

Cyclopamine was obtained from Toronto Research Chemicals, Inc. Docetaxel, 3′,3′-dihexyloxacarbocyanine iodide [DiOC6(3)], MTT, and EGF were purchased from ...

Product Name. Cyclopamine-KAAD , Cyclopamine- KAAD, CAS 306387-90-6, is a cell-permeable potent analog of Cyclopamine (Cat. No. 239803) that specifically ...

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by YF Yuan · 2020 · Cited by 15 — Cyclopamine could inhibit epithelial and stromal cell proliferation , and induce epithelial cell apoptosis by suppressing the Hedgehog signaling pathway.