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HO-PEG-CO-OtBu is a linear heterobifunctional polyethylene glycol (PEG) derivative, featuring a terminal hydroxyl (
) group and a protected carboxyl group (
). This compound acts as a versatile building block in drug delivery, nanotechnology, and surface modification, enabling coupling at the hydroxyl end while protecting the carboxylate for subsequent activation.
Key Aspects & Properties
- Structure: Hydroxyl-PEG-carboxylic acid tert-butyl ester (HO-PEG-COOtBu).
- Protection: The tert-butyl ester prevents self-coupling/polymerization under standard carboxylic acid conditions.
- Deprotection: The carboxyl group can be regenerated via acidic conditions, such as trifluoroacetic acid (TFA).
- Applications: Cell culture, drug research, drug delivery, and nanoparticle modification.
- Storage: Requires long-term storage at , often under inert gas (nitrogen or argon) to avoid degradation.
Available Derivatives & Variants
This compound is available in various molecular weights and PEG chain lengths, often listed with specific PEG counts, such as:
This compound is available in various molecular weights and PEG chain lengths, often listed with specific PEG counts, such as:
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Web results
HO-PEG-COOtBu
BOC Sciences
https://peg.bocsci.com › products › ho-peg-cootbu-6081
BOC Sciences
https://peg.bocsci.com › products › ho-peg-cootbu-6081
HO-PEG-COOtBu is used in cell culture, drug research, drug delivery and release, nanotechnology and new materials. It can also be attached to different ...Read more
HO-PEG(6)-CO-OtBu
Iris Biotech GmbH
https://iris-biotech.de › peg2355
Iris Biotech GmbH
https://iris-biotech.de › peg2355
HO-PEG(6)-CO-OtBu · Product code: PEG2355 · CAS No.: 361189-64-2 · Formula: C19H38O · Storage temperature: -20°C · Molecular weight: 410,5 g/mol.
HO-PEG-COOtBu - NSP-Functional Polymers & Copolymers
nanosoftpolymers.com
https://www.nanosoftpolymers.com › product › ho-peg...
nanosoftpolymers.com
https://www.nanosoftpolymers.com › product › ho-peg...
HO-PEG-COOtBu is a linear heterobifunctional PEG derivative with one hydroxyl group and one carboxylate tert-butyl ester.
$260.00 to $1,500.00In stock
Missing: CO- OtBu
Hydroxy-dPEG®24-t-butyl ester >90% (HPLC)
Sigma-Aldrich
https://www.sigmaaldrich.com › aldrich › qbd10722
Sigma-Aldrich
https://www.sigmaaldrich.com › aldrich › qbd10722
Hydroxy-dPEG24-t-butyl ester is a versatile building block based upon a monodispersed polyethylene glycol (PEG) chain, comparable to a polymeric PEG1000.Read more
$342.002–4 day delivery
HO-PEG-COOtBu - CD Bioparticles
cd-bioparticles.net
https://www.cd-bioparticles.net › ho-peg-cootbu
cd-bioparticles.net
https://www.cd-bioparticles.net › ho-peg-cootbu
HO-PEG-COOtBu is a linear heterobifunctional PEG derivative with one hydroxyl group and one carboxylate tert-butyl ester.
$740.00$80 delivery
Ho-peg(6)-co-otbu
Chemrio International Limited
https://www.chemrio.com › shop › product › ho-peg-6-...
Chemrio International Limited
https://www.chemrio.com › shop › product › ho-peg-6-...
Product not available ... Free Shipping in U.S.. Buy now, get in 2 days.Read more
Ho Peg Co Otbu
SINOPEG
https://www.sinopeg.com › ho-peg-co-otbu_sp
SINOPEG
https://www.sinopeg.com › ho-peg-co-otbu_sp
C9H18O4. Product Name:HO-PEG1-CH2CH2COOtBu. CAS No.:671802-00-9. M.F.:C9H18O4. M.W:190.23682. Storage:-18℃ for long term storage,avoid light. Purity:>95%.
Hydroxy-PEG6-t-butyl ester | C19H38O9 | CID 51341046
National Institutes of Health (.gov)
https://pubchem.ncbi.nlm.nih.gov › compound
National Institutes of Health (.gov)
https://pubchem.ncbi.nlm.nih.gov › compound
Hydroxy-PEG6-t-butyl ester | C19H38O9 | CID 51341046 - structure, chemical names, physical and chemical properties, classification, patents, literature, ...
Hydroxy-peg24-t-butyl ester | Adc linker, protected acid peg
PurePEG
https://purepeg.com › product
PurePEG
https://purepeg.com › product
Purchase PurePEG High Purity HO-PEG24-CH2COOtBu PEG Linker, and other variations for Biomedical Applications. Same Day Shipping!
$238.00 to $717.00Out of stock
HO-PEG(24)-CO-tbu -
Sigma-Aldrich
https://www.sigmaaldrich.com › substance
Sigma-Aldrich
https://www.sigmaaldrich.com › substance
HO-PEG(24)-CO-tbu. CAS 1186025-29-5. Molecular Weight 1203.46. Browse HO-PEG(24)-CO-tbu and related products at Merck.