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[CBZ-L-HABA (Acidol-4-Benzyloxycarbonyl-Amino-2-Hydroxy Butyric Acid, CAS: 262368-30-9 or 40371-50-4) is a critical protected intermediate used in the synthesis of Amikacin, a semisynthetic aminoglycoside antibiotic. This compound is used to attach the (L)-AHB side chain to kanamycin A, which provides amikacin with its resistance to many aminoglycoside-modifying enzymes. 

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Application in Amikacin Synthesis
Amikacin is a semi-synthetic derivative of Kanamycin. The incorporation of the (S)-4-amino-2-hydroxybutyryl (AHB) side chain (derived from CBZ-L-HABA) at the

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position of the 2-deoxystreptamine ring is crucial for its therapeutic efficacy against resistant Gram-negative bacteria. The CBZ (carboxybenzyl) group serves as a protecting group that is removed later in the synthesis process. 

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