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    An AI Overview is not available for this searchCan't generate an AI overview right now. Try again later.
    AI Overview
    Menthol Carboxamide (WS-3) is a high-purity, synthetic cooling agent (
    𝐶13
    𝐻25
    𝑁𝑂
    ) widely used in pharmaceutical, oral care, and personal care products for its intense, long-lasting cooling effect. Unlike menthol, it is odorless, tasteless, and non-volatile, providing a clean, immediate sensation (mostly at the roof and back of the mouth) without bitterness. 
    Key Aspects of WS-3 Cooling Agent: 
    • Medical/Pharmaceutical Use: Utilized in cough syrups, lozenges, throat sprays, and topicals (creams/gels) to offer a soothing, fresh sensation. 
    • Properties: Appears as a white crystalline powder with a melting point of 95–98°C. It is insoluble in water but soluble in alcohols. 
    • Effect: Offers a strong cooling intensity (rated 1.5–2 times higher than menthol in some applications) and lasts up to 6 minutes or longer. 
    • Applications:
      • Pharmaceuticals: Lozenges, tablets, gels, and ointments.
      • Oral Care: Toothpaste and mouthwash.
      • Cosmetics: Lip balms, lipsticks, and skin lotions.
      • Other: Food/beverage and e-cigarettes. 
    • Safety/Evaluation: Studies suggest that at prescribed concentrations, WS-3 is safe for consumption, but high-dose inhalation studies have shown potential pulmonary and system impacts in animal studies. 
    WS-3 acts as a high-quality substitute or enhancer for traditional mint flavors, delivering a faster, cleaner, and more durable cooling effect. 
    Show more

    Web results

    The role of synthetic coolants, WS-3 and WS-23, in modulating ...


    PubMed Central (PMC) (.gov)
    https://pmc.ncbi.nlm.nih.gov › articles › PMC9742959
    PubMed Central (PMC) (.gov)
    https://pmc.ncbi.nlm.nih.gov › articles › PMC9742959
    by S Yogeswaran · 2022 · Cited by 20 — Synthetic cooling agents (WS-23 and WS-3) provide a cooling sensation. Coolants in e-cigarettes modify acellular and ROS levels in lung epithelial cells.Read more
    Missing: Grade ‎| Show results with: Grade
    People also ask
    What is a WS3 cooling agent?
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    Is WS-3 safe?
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    Is koolada ws-3?
    Cooling agent WS-3 (as known as Koolada 3, N-Ethyl-p-menthane-3-carboxamide) is a synthetic compound used to provide a cooling sensation in various consumer products.

    Cooling Agents WS-3 - Foreverest Resources Ltd


    Foreverest Resources Ltd
    https://foreverest.net › Other Specialty Chemicals
    Foreverest Resources Ltd
    https://foreverest.net › Other Specialty Chemicals
    What is WS-3?
    An error has occurred. Please try again later.

    Ask anything in AI Mode

    Explain how WS-3 creates a cooling sensation
    List other synthetic cooling agents
    Tell me more about Menthol Carboxamide

    Web results

    Cooling Agent WS-3


    Titanos Group
    https://www.titanos.com › product-72342414794162176
    Titanos Group
    https://www.titanos.com › product-72342414794162176
    WS-3 is a white powder crystal, used as a cooling agent for skin and lipstick. It is performed as a cooling agent in mint formulas, various spice formulas ...Read more
    Missing: Medical ‎| Show results with: Medical

    Cooling Agent WS-3


    Alfa Chemistry
    https://ffc.alfa-chemistry.com › ... › Cooling Agents
    Alfa Chemistry
    https://ffc.alfa-chemistry.com › ... › Cooling Agents
    WS-3 is a popular synthetic cooling agent used in a wide range of food, beverage, cosmetic and personal care products.Read more
    Missing: Medical ‎| Show results with: Medical

    WS-3 Cooling Agent: Applications, Benefits, and ...


    Anhui Chinaherb Flavors&Fragrances Co.,Ltd.
    https://www.cnherbflavor.com › blog › ws-3-cooling-ag...
    Anhui Chinaherb Flavors&Fragrances Co.,Ltd.
    https://www.cnherbflavor.com › blog › ws-3-cooling-ag...
    May 9, 2025 — WS-3 is a synthetic cooling compound developed to provide a stronger cooling impact than traditional menthol.Read more

    Cooling Agents WS-3


    Foreverest Resources Ltd
    https://foreverest.net › Other Specialty Chemicals
    Foreverest Resources Ltd
    https://foreverest.net › Other Specialty Chemicals
    It offers a cooling effect of 1.5 and lasts up to 6 minutes. It is valued for its mild, pleasant, and long-lasting cooling properties.Read more

    Menthol Carboxamide(WS-3)


    Fingredients
    https://www.fingredients.com › Collections › Flavors
    Fingredients
    https://www.fingredients.com › Collections › Flavors
    Menthol Carboxamide (WS-3) is a high-purity, food-grade cooling agent providing a smooth, long-lasting cooling effect. Ideal for applications in chewing gum ...
    Missing: Medical ‎| Show results with: Medical

    WS-3 N-ethyl 2-isopropyl-5-methylcyclohexanecarboxamide


    The Good Scents Company
    https://www.thegoodscentscompany.com › data
    The Good Scents Company
    https://www.thegoodscentscompany.com › data
    Odor Type: minty. Odor Strength:low. mentholic minty alcoholic cooling. Odor Description:at 25.00 % in dipropylene glycol. mild mentholic mintyRead more

    Symcool® WS-3 (Cooling Agent) by Symrise


    SpecialChem
    https://www.specialchem.com › ... › Symrise › Symcool
    SpecialChem
    https://www.specialchem.com › ... › Symrise › Symcool
    May 28, 2025 — Ethyl Menthane Carboxamide. Symcool® WS-3 by Symrise acts as a cooling agent. It offers a cool sensation on the skin without any minty odor.Read more

    Cooling Agent Hierarchy: WS-3 vs. WS-5 vs. WS-23 Usage ...


    Cuiguai
    https://www.cuiguai.com › cooling-agent-hierarchy-whe...
    Cuiguai
    https://www.cuiguai.com › cooling-agent-hierarchy-whe...
    Jan 10, 2026 — Master the science of vape cooling agents. A 3000-word technical guide on when to use WS-23, WS-3, and WS-5. Learn about TRPM8 receptor ...

    Evaluation of synthetic cooling agents WS-3 and WS-23 in ...


    CORESTA
    https://www.coresta.org › abstracts › evaluation-synthetic...
    CORESTA
    https://www.coresta.org › abstracts › evaluation-synthetic...
    Here, we discuss the toxicological effects via inhalation of WS-3 and WS-23 in separate 90-day nose-only inhalation toxicity studies in rats.Read more
    Missing: Medical ‎Grade
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