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8-arm Poly(ethylene glycol) propionaldehyde(HG) [8-arm PEG-pALD(HG)] is a multi-armed, high-purity reactive PEG derivative featuring a hexaglycerol core and terminal aldehyde groups. It is widely used in biomedical research, particularly for crosslinking, hydrogel formation, and modifying proteins/peptides via PEGylation, with available molecular weights typically ranging from 2K to 40K Da.
Key Features & Applications
- Structure: Eight PEG arms connected to a central hexaglycerol (HG) core, providing high-density functionalization.
- Functional Group: Propionaldehyde (pALD) groups are highly reactive towards amine groups, making them suitable for forming reversible or irreversible bonds (via reduction) with proteins or drug delivery carriers.
- Hydrogel Formation: Commonly used as a crosslinking reagent in the development of biocompatible PEG-based hydrogels.
- High Purity: Available in narrow polydispersity (PDI) for consistent, reproducible molecular weight distribution.
Product Specifications
- Core Structure: Hexaglycerol (HG).
- Molecular Weights (MW): Commonly offered at 2K, 5K, 10K, 20K, and 40K Da.
- Appearance: Typically white or off-white powder.
- Storage Conditions: Recommended to be stored at , kept dry, and protected from moisture.
- Reactivity: The aldehyde group reacts with amino groups under mild conditions, optimal at a pH of 6–9.5, for surface modification.
8-arm PEG-pALD(HG) is often used in conjugation with amino-containing molecules or for crosslinking with other multi-arm functionalized PEGs, available from specialized suppliers like SINOPEG.
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8-arm Poly(ethylene Glycol) Propionaldehyde(HG) [8- ...
SINOPEG
https://www.sinopeg.com › 8-arm PEG (HG)
SINOPEG
https://www.sinopeg.com › 8-arm PEG (HG)
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8-arm Poly(ethylene glycol) propionaldehyde(HG) (8-arm PEG-pALD(HG)) is available with molecular weight 2K, 5K, 10K, 20K and 40K Da, other M.W. may be available ...Read more
8-arm Poly(ethylene glycol) propionaldehyde(TP) [8- ...
Alfa Chemistry
https://vaccinelab.alfa-chemistry.com › product › arm-po...
Alfa Chemistry
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Catalog Number, VL-PD00096. Structure. Synonyms, 8-arm PEG-pALD(TP). Molecular Weight, 5KDa, 10KDa, 20KDa, 40KDa. Storage, Store at -20±5°C, keep dry.Read more
Pa Peg Pa
SINOPEG
https://www.sinopeg.com › pa-peg-pa_sp
SINOPEG
https://www.sinopeg.com › pa-peg-pa_sp
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Linear PEG · 8-arm Poly(ethylene glycol) propionaldehyde(HG) [8-arm PEG-pALD(HG)]. 8-arm PEG-pALD(HG). Product ...Read more
8-Arm PEG-OH - Creative PEGWorks | PEG Products Leader
Creative PEGWorks
https://creativepegworks.com › Products
Creative PEGWorks
https://creativepegworks.com › Products
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We offer two types of 8-Arm PEG, one has the hexaglycerol core (HG core) and one has the tripentaerythritol core (TP core) that connects to 8 identical arms.Read more
Research progress on the PEGylation of therapeutic proteins ...
National Institutes of Health (.gov)
https://pmc.ncbi.nlm.nih.gov › articles › PMC10960368
National Institutes of Health (.gov)
https://pmc.ncbi.nlm.nih.gov › articles › PMC10960368
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by C Li2024Cited by 77 — Polyethylene glycol (PEG) modification offers an effective solution to these issues due to its favorable properties. This review presents recent progress in the ...Read more
PEG Derivative by Functional Group
SINOPEG
https://www.sinopeg.com › cho_c108
SINOPEG
https://www.sinopeg.com › cho_c108
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8-arm PEG-pALD(HG). Product Name: 8-arm Poly(ethylene glycol) propionaldehyde(HG). Abbreviation: 8-arm PEG-pALD(HG). Molecular Weight: 2KDa, 5KDa, 10KDa, ...Read more
People also ask
What is PEG in Dr Pepper?
Poly (ethylene glycol) is also commonly used as a polar stationary phase for gas chromatography, as well as a heat transfer fluid in electronic testers. PEG is included in many or all formulations of the soft drink Dr Pepper, purportedly as an anti-foaming agent.
Polyethylene glycol - chemeurope.com
chemeurope.com
https://www.chemeurope.com › encyclopedia › Polyethy...
chemeurope.com
https://www.chemeurope.com › encyclopedia › Polyethy...
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What is PEG 20000 used for?
Polyethylene glycol 20000 (PEG-20000) can be used as a pore-expanding agent to prepare mesoporous La2O3 catalyst via hydrothermal process. The effect of PEG 20000 on La2O3 catalyst particles, results in increased alkalinity, crystallinity, specific surface area, and dispersion.
Polyethylene glycol 20000 (stabilised) for synthesis 25322-68-3
MilliporeSigma
https://www.sigmaaldrich.com › product
MilliporeSigma
https://www.sigmaaldrich.com › product
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Web results
List of PEG Derivatives Application
Biopharma PEG
https://www.biochempeg.com › article
Biopharma PEG
https://www.biochempeg.com › article
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Jan 9, 2020 — List of PEG Derivatives Application ; 8arm PEG Thiol (hexaglycerol), Hydrogel ; 8arm Polyethylene Glycol (hexaglycerol), Hydrogel ; Acrylate PEG ...Read more
8-Arm-PEG-CHO (MW 20000) | PEG Derivative
MedchemExpress.com
https://www.medchemexpress.com › 8-arm-peg-cho-mw...
MedchemExpress.com
https://www.medchemexpress.com › 8-arm-peg-cho-mw...
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8-Arm-PEG-CHO (MW 20000) is a polyethylene glycol derivative with multiple active aldehyde groups, which can be used to construct drug delivery carriers.
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PEG Raw Materials
JenKem Technology USA
https://jenkemusa.com › peg-raw-materials
JenKem Technology USA
https://jenkemusa.com › peg-raw-materials
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Apr 10, 2026 — Multi-Arm PEG Raw Materials. 8ARM TP CORE ADVANTAGES. JenKem Technology provides 4ARM and 8ARM PEG raw materials in 100g-500g online order size.Read more
Missing: propionaldehyde( HG)
Pegylated hemoglobin and albumin and uses thereof
Google Patents
https://patents.google.com › patent
Google Patents
https://patents.google.com › patent
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The present invention provides PEGylated hemoglobins and PEGylated albumins comprising polyethylene glycol (PEG) conjugated to hemoglobin or to albumin, ...