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H2N-PEG3-CH2CH2COOtBu
(CAS 252881-74-6) is a heterobifunctional monodisperse polyethylene glycol (PEG) linker containing an amino () group at one end and a t-butyl protected carboxyl (
) group at the other. This hydrophilic spacer is widely used in PROTAC synthesis, drug delivery systems, and surface modification, offering a specific chemical structure and precise molecular weight.
Key Characteristics & Properties
- Formula:
- Molecular Weight:
- Structure:
- Purity: Typically
- Appearance: Colorless liquid/solid
- Solubility: High solubility in water and aqueous media
Reactivity & Applications
- Amino Group: Reactive with carboxylic acids, activated NHS esters, and carbonyls (ketones/aldehydes).
- t-Butyl Protected Carboxyl: Stable, but can be deprotected (hydrolyzed) under acidic conditions.
- PROTAC Linker: Used in the synthesis of Proteolysis Targeting Chimeras (PROTACs) as a spacer.
- Bioconjugation: Ideal for creating stable, functionalized biomaterials in diagnostic and therapeutic applications.
- Surface Modification: Used to reduce protein adsorption and improve biocompatibility of nanoparticles.
Storage Conditions
- Store at (long-term)
- Avoid light
Note: The product is commonly sold by specialized chemical suppliers like PurePEG and CP Lab Safety.
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High Purity PEG Reagent, H2N-PEG3-CH2CH2COOtBu, 95% ...
CP Lab Safety
https://www.calpaclab.com › high-purity-peg-reagent-h2...
CP Lab Safety
https://www.calpaclab.com › high-purity-peg-reagent-h2...
High Purity PEG Reagent, H2N-PEG3-CH2CH2COOtBu, 95% Min Purity, 1 gram ; CAS Number: 252881-74-6 ; Product Volume · 1 gram ; Formula · C13H27NO5 ; Material ...
H2N-PEG3-CH2CH2COOtBu
PurePEG
https://purepeg.com › product › h2n-peg3-ch2ch2cootbu
PurePEG
https://purepeg.com › product › h2n-peg3-ch2ch2cootbu
Purchase PurePEG High Purity PEG Linker H2N-PEG3-CH2CH2COOtBu and other variations for Biomedical Applications. Same Day Shipping!
$11.00 to $78.00In stock$45 delivery
Amino-PEG3-t-butyl ester, 252881-74-6
Biopharma PEG
https://www.biochempeg.com › product
Biopharma PEG
https://www.biochempeg.com › product
Monodisperse Amino-PEG3-t-butyl ester (NH2-PEG3-CH2CH2COOtBu) is a heterobifunctional PEG linker containing an amino (NH2) group with a t-butyl protected ...
$140.00$55 delivery
H2N-PEG3-CH2COOtBu | 189808-70-6
ChemicalBook
https://amp.chemicalbook.com › ChemicalProductPrope...
ChemicalBook
https://amp.chemicalbook.com › ChemicalProductPrope...
H2N-PEG3-CH2COOtBu ; form: Liquid ; color: Colorless to light yellow ; Signal word: Warning ; Hazard statements. H315Causes skin irritation. H319Causes serious eye ...Read more
H2N-PEG3-CH2CH2COOtBu [C13H27NO5] Cas:252881-74-6
SINOPEG
https://www.sinopeg.com › h2n-peg3-ch2ch2cootbu-c1...
SINOPEG
https://www.sinopeg.com › h2n-peg3-ch2ch2cootbu-c1...
Product Name · H2N-PEG3-CH2CH2COOtBu ; CAS No. · 252881-74-6 ; Storage:-18℃ for long term storage,avoid light ; Appearance · White or Off-White Solid.
H2N-PEG3-CH2CH2COOtBu - CAS:252881-74-6
Yanfen Biotech
https://en.yanfenbio.com › PNOPEGE403
Yanfen Biotech
https://en.yanfenbio.com › PNOPEGE403
Product Number： PEGE403 ; IUPAC Name： tert-butyl 3-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]propanoate ; CAS Number： 252881-74-6.
High Purity PEG Reagent, H2N-PEG3-CH2CH2COOtBu, ...
CP Lab Safety
https://www.calpaclab.com › high-purity-peg-reagent-h2...
CP Lab Safety
https://www.calpaclab.com › high-purity-peg-reagent-h2...
High Purity PEG Reagent, H2N-PEG3-CH2CH2COOtBu, 97% Min Purity, 5 grams ; Style: chemical ; CAS Number: 252881-74-6 ; Product Volume · 5 grams ; Formula · C13H27NO5 ...Read more
$324.75In stockFree delivery30-day returns
NH2-PEG3-CH2CH2COOtBu | CAS:252881-74-6
Huateng Pharma
https://en.huatengsci.com › product
Huateng Pharma
https://en.huatengsci.com › product
Huateng Pharma offers high purity NH2-PEG3-CH2CH2COOtBu, CAS NO. 252881-74-6 and even custom PEG synthesis. High purity, fast shipping.
H2N-PEG3-CH2CH2COOtBu - Biochempeg
Divbio Science Europe
https://divbio.eu › Home › Suppliers › Biochempeg
Divbio Science Europe
https://divbio.eu › Home › Suppliers › Biochempeg
Based on proprietary technologies, Biochempeg Scientific Inc. is capable of supplying small to large quantities of high quality PEGs for customers worldwide.
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Pharmint
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Pharmint
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H2N-PEG3-CH2CH2COOtBu ... Active Pharmaceutical Ingredient (API) is the biologically active component of a drug product (tablet, capsule, cream, injectable) that ...